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Scientific publications

2019

Régnier M, Polizzi A, Lukowicz C, Smati S, Lasserre F, Lippi Y, Naylies C, Laffitte J, Bétoulières C, Montagner A, Ducheix S, Gourbeyre P, Ellero-Simatos S, Menard S, Bertrand-Michel J, Al Saati T, Lobaccaro JM, Burger HM, Gelderblom WC, Guillou H, Oswald IP, Loiseau N. The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity. Arch Toxicol. 2019 93: 505. doi.org/10.1007/s00204-018-2345-2.

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Morigny P, Houssier M, Mairal A, Ghilain C, Mouisel E, Benhamed F, Masri B, Recazens E, Denechaud P-D, Tavernier G, Caspar-Bauguil S, Virtue S, Sramkova V, Monbrun L,Mazars A, Zanoun M, Guilmeau S, Barquissau V, Beuzelin D, Bonnel S, Marques M, Monge-Roffarello B, Lefort C, Fielding B, Sulpice T, Astrup A, Payrastre B, Bertrand-Michel J, Meugnier E, Ligat L, Lopez F, Guillou H, Ling C, Holm C, Rabasa-Lhoret R, Saris W H M, Stich V, Arner P, Rydén M, Moro C, Viguerie N, Harms M, Hallén S, Vidal-Puig A, Vidal H, Postic C, Langin D. Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity. Nature Metabolism 2019 1(1): 133-46. doi.org/10.1038/s42255-018-0007-6.

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Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B. Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol. 2019 Jan 21. pii: S0168-8278(19)30027-3. doi: 10.1016/j.jhep.2018.12.037.

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Habib A, Chokr D, Wan J, Hegde P, Mabire M, Siebert M, Ribeiro-Parenti L, Le Gall M, Lettéron P, Pilard N, Mansouri A, Brouillet A, Tardelli M, Weiss E, Le Faouder P, Guillou H, Cravatt BF, Moreau R, Trauner M, Lotersztajn S. Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver. Gut. 2018 Oct 9. pii: gutjnl-2018-316137. doi: 10.1136/gutjnl-2018-316137.

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Montagner A, Le Cam L, Guillou H. β-catenin oncogenic activation rewires fatty acid catabolism to fuel hepatocellular carcinoma. Gut. 2019 Feb;68(2):183-185. doi: 10.1136/gutjnl-2018-316557.

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2018

Lukowicz C, Ellero-Simatos S, Régnier M, Polizzi A, Lasserre F, Montagner A, Lippi Y, Jamin EL, Martin JF, Naylies C, Canlet C, Debrauwer L, Bertrand-Michel J, Al Saati T, Théodorou V, Loiseau N, Mselli-Lakhal L, Guillou H, Gamet-Payrastre L. Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor. Environ Health Perspect. 2018 Jun 25;126(6):067007. doi: 10.1289/EHP2877.

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Bricambert J, Alves-Guerra MC, Esteves P, Prip-Buus C, Bertrand-Michel J, Guillou H, Chang CJ, Vander Wal MN, Canonne-Hergaux F, Mathurin P, Raverdy V, Pattou F, Girard J, Postic C, Dentin R. The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. Nat Commun. 2018 May 29;9(1):2092. doi: 10.1038/s41467-018-04361-y.

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Monteillet L, Gjorgjieva M, Silva M, Verzieux V, Imikirene L, Duchampt A, Guillou H, Mithieux G, Rajas F. Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context. Mol Metab. 2018 Aug 1. pii: S2212-8778(18)30646-X. doi: 10.1016/j.molmet.2018.07.006.

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Zarei M, Barroso E, Palomer X, Dai J, Rada P, Quesada-López T, Escolà-Gil JC, Cedó L, Zali MR, Molaei M, Dabiri R, Vázquez S, Pujol E, Valverde ÁM, Villarroya F, Liu Y, Wahli W, Vázquez-Carrera M. Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease. Mol Metab. 2018 Feb;8:117-131. doi: 10.1016/j.molmet.2017.12.008.

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Lacunza E, Montanaro MA, Salvati A, Memoli D, Rizzo F, Henning MF, Quiroga IY, Guillou H, Abba MC, Gonzalez-Baro MDR, Weisz A, Pellon-Maison M. Small non-coding RNA landscape is modified by GPAT2 silencing in MDA-MB-231 cells. Oncotarget. 2018 Jun 15;9(46):28141-28154. doi: 10.18632/oncotarget.25582.

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Tan EHP, Sng MK, How ISB, Chan JSK, Chen J, Tan CK, Wahli W, Tan NS. ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response. Oncogene. 2018 Apr;37(15):2067-2078. doi: 10.1038/s41388-017-0109-8.

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Riba A, Olier M, Lacroix-Lamandé S, Lencina C, Bacquié V, Harkat C, Van Langendonck N, Gillet M, Cartier C, Baron M, Sommer C, Mallet V, Zill M, Robert H, Laurent F, Ellero-Simatos S, Théodorou V, Ménard S. Early life stress in mice is a suitable model for Irritable Bowel Syndrome but does not predispose to colitis nor increase susceptibility to enteric infections. Brain Behav Immun. 2018 May 31. pii: S0889-1591(18)30200-9. doi: 10.1016/j.bbi.2018.05.024.

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Guerville M, Hamilton MK, Ronveaux CC, Ellero-Simatos S, Raybould HE, Boudry G. Chronic refined low-fat diet consumption reduces cholecystokinin satiation in rats. Eur J Nutr. 2018 Aug 1. doi: 10.1007/s00394-018-1802-2.

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Régnier M, Polizzi A, Guillou H, Loiseau N. Sphingolipid metabolism in non-alcoholic fatty liver diseases. Biochimie. 2018 Jul 30. pii: S0300-9084(18)30216-5. doi: 10.1016/j.biochi.2018.07.021.

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Duszka K, Ellero-Simatos S, Ow GS, Defernez M, Paramalingam E, Tett A, Ying S, König J, Narbad A, Kuznetsov VA, Guillou H, Wahli W. Complementary intestinal mucosa and microbiota responses to caloric restriction. Sci Rep. 2018 Jul 27;8(1):11338. doi: 10.1038/s41598-018-29815-7.

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Podechard N, Ducheix S, Polizzi A, Lasserre F, Montagner A, Legagneux V, Fouché E, Saez F, Lobaccaro JM, Lakhal L, Ellero-Simatos S, Martin PG, Loiseau N, Bertrand-Michel J, Guillou H. Dual extraction of mRNA and lipids from a single biological sample. Sci Rep. 2018 May 4;8(1):7019. doi: 10.1038/s41598-018-25332-9.

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Chen J, Montagner A, Tan NS, Wahli W. Insights into the Role of PPARβ/δ in NAFLD. Int J Mol Sci. 2018 Jun 27;19(7). pii: E1893. doi: 10.3390/ijms19071893.

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Sng MK, Chan JSK, Teo Z, Phua T, Tan EHP, Wee JWK, Koh NJN, Tan CK, Chen JP, Pal M, Tong BMK, Tnay YL, Ng XR, Zhu P, Chiba S, Wang X, Wahli W, Tan NS. Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression. Cell Discov. 2018 Apr 3;4:15. doi: 10.1038/s41421-018-0014-5.

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Régnier M, Polizzi A, Lippi Y, Fouché E, Michel G, Lukowicz C, Smati S, Marrot A, Lasserre F, Naylies C, Batut A, Viars F, Bertrand-Michel J, Postic C, Loiseau N, Wahli W, Guillou H, Montagner A. Insights into the role of hepatocyte PPARα activity in response to fasting. Mol Cell Endocrinol. 2018 Aug 15;471:75-88. doi: 10.1016/j.mce.2017.07.035.

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Boussadia B, Lakhal L, Payrastre L, Ghosh C, Pascussi JM, Gangarossa G, Marchi N. Pregnane X receptor deletion modifies recognition memory and electroencephalographic activity. Neuroscience. 2018 Feb 1;370:130-138. doi: 10.1016/j.neuroscience.2017.07.038.

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2017

Malaisé Y, Menard S, Cartier C, Gaultier E, Lasserre F, Lencina C, Harkat C, Geoffre N, Lakhal L, Castan I, Olier M, Houdeau E, Guzylack-Piriou L. Gut dysbiosis and impairment of immune system homeostasis in perinatally-exposed mice to Bisphenol A precede obese phenotype development. Sci Rep. 2017 Nov 3;7(1):14472.

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Duszka K, Oresic M, Le May C, König J, Wahli W. PPARγ Modulates Long Chain Fatty Acid Processing in the Intestinal Epithelium. Int J Mol Sci. 2017 Nov 28;18(12). pii: E2559. doi: 10.3390/ijms18122559.

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Cattaneo ER, Prieto ED, Garcia-Fabiani MB, Montanaro MA, Guillou H, Gonzalez-Baro MR. Glycerol-3-phosphate acyltransferase 2 expression modulates cell roughness and membrane permeability: An atomic force microscopy study. PLoS One. 2017 Dec 6;12(12):e0189031. doi: 10.1371/journal.pone.0189031.

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Iroz A, Montagner A, Benhamed F, Levavasseur F, Polizzi A, Anthony E, Régnier MFouché ELukowicz C, Cauzac M, Tournier E, Do-Cruzeiro M, Daujat-Chavanieu M, Gerbal-Chalouin S, Fauveau V, Marmier S, Burnol AF, Guilmeau S, Lippi Y, Girard J, Wahli W, Dentin R, Guillou H, Postic C. A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response. Cell Rep. 2017 Oct 10;21(2):403-416. doi: 10.1016/j.celrep.2017.09.065.

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Régnier M, Gourbeyre P, Pinton P, Napper S, Laffite J, Cossalter AM, Bailly JD, Lippi Y, Bertrand-Michel J, Bracarense APFRL, Guillou H, Loiseau N, Oswald IP. Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine. Mol Nutr Food Res. 2017 Sep 5. doi: 10.1002/mnfr.201700433.

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Ducheix S, Montagner A, Polizzi A, Lasserre F, Régnier M, Marmugi A, Benhamed F, Bertrand-Michel J, Mselli-Lakhal L, Loiseau N, Martin PG, Lobaccaro JM, Ferrier L, Postic C, Guillou H. Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling. PLoS One. 2017 Jul 21;12(7):e0181393. doi: 10.1371/journal.pone.0181393. eCollection 2017.

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Van Maele-Fabry G, Gamet-Payrastre L, Lison D. Residential exposure to pesticides as risk factor for childhood and young adult brain tumors: A systematic review and meta-analysis. Environ Int. 2017 Jun 14;106:69-90.

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Guillaume M, Handgraaf S, Fabre A, Raymond-Letron I, Riant E, Montagner A, Vinel A, Buscato M, Smirnova N, Fontaine C, Guillou H, Arnal JF, Gourdy P. Selective Activation of Estrogen Receptor α Activation Function-1 Is Sufficient to Prevent Obesity, Steatosis, and Insulin Resistance in Mouse. Am J Pathol. 2017 Jun;187(6):1273-1287.

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2016

Polizzi A, Fouché E, Ducheix S, Lasserre F, Marmugi AP, Mselli-Lakhal L, Loiseau N, Wahli W, Guillou H, Montagner A. Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids. Int J Mol Sci. 2016 Sep 24;17(10). pii: E1624. doi: 10.3390/ijms17101624.

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Duszka K, Picard A, Ellero-Simatos S, Defernez M, Pigram A, Vanoaica L, Parini P, Narbad A, Guillou H, Thorens B, Wahli W. Intestinal PPARγ modulates body fat composition and sympathetic nervous system activation in calorie restricted mice. Sci Rep. 2016 in press.

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Tan NS, Vázquez-Carrera M, Montagner A, Sng MK, Guillou H, Wahli W. Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ. Prog Lipid Res. 2016 Sep 22. pii: S0163-7827(16)30013-3. doi: 10.1016/j.plipres.2016.09.001.

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Casteras S, Abdul-Wahed A, Soty M, Vulin F, Guillou H, Campana M, Le Stunff H, Pirola L, Rajas F, Mithieux G, Gautier-Stein A. The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice. Diabetologia. 2016 Sep 9.

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Payros D, Alassane-Kpembi I, Pierron A, Loiseau N, Pinton P, Oswald IP. Toxicology of deoxynivalenol and its acetylated and modified forms. Arch Toxicol. 2016 Sep 23.

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Pierron A, Mimoun S, Murate LS, Loiseau N, Lippi Y, Bracarense AF, Schatzmayr G, He JW, Zhou T, Moll WD, Oswald IP. Microbial biotransformation of DON: molecular basis for reduced toxicity. Sci Rep. 2016 Jul 6;6:29105.

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Rando G, Tan CK, Khaled N, Montagner A, Leuenberger N, Bertrand-Michel J, Paramalingam E, Guillou H, Wahli W. Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism. Elife. 2016 Jul 1;5. pii: e11853.

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Rizzati V, Briand O, Guillou H, Gamet-Payrastre L. Effects of pesticide mixtures in human and animal models: An update of the recent literature. Chem Biol Interact. 2016 Jul 25;254:231-46.

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Boussadia B, Gangarossa G, Mselli-Lakhal L, Rousset MC, de Bock F, Lassere F, Ghosh C, Pascussi JM, Janigro D, Marchi N. Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo. Exp Neurol. 2016 May 27;283(Pt A):39-48.

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Hermier D, Guelzim N, Martin PG, Huneau JF, Mathé V, Quignard-Boulangé A, Lasserre F, Mariotti F. NO synthesis from arginine is favored by α-linolenic acid in mice fed a high-fat diet. Amino Acids. 2016 May 13.

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Marmugi A, Lukowicz C, Lasserre F, Montagner A, Polizzi A, Ducheix S, Goron A, Gamet-Payrastre L, Gerbal-Chaloin S, Pascussi JM, Moldes M, Pineau T, Guillou H, Mselli-Lakhal L. Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way. Toxicol Appl Pharmacol. 2016 May 11;303:90-100.

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Popineau L, Morzyglod L, Carré N, Caüzac M, Bossard P, Prip-Buus C, Lenoir V, Ragazzon B, Fauveau V, Robert L, Guilmeau S, Postic C, Komatsu M, Canonne-Hergaux F, Guillou H, Burnol AF. A novel Grb14-mediated cross-talk between insulin and p62/Nrf2 pathways regulates liver lipogenesis and selective insulin resistance. Mol Cell Biol. 2016 May 23. pii: MCB.00170-16.

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Claus SP, Guillou H, Ellero-Simatos S. The gut microbiota: a major player in the toxicity of environmental pollutants? npj Biofilms and Microbiomes 2016, 2:16003 doi:10.1038/npjbiofilms.2016.3

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Barquissau V, Beuzelin D, Pisani DF, Beranger GE, Mairal A, Montagner A, Roussel B, Tavernier G, Marques MA, Moro C, Guillou H, Amri EZ, Langin D. White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways. Mol Metab. 2016 Mar 18;5(5):352-65. doi: 10.1016/j.molmet.2016.03.002

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Montagner A, Polizzi A, Fouché E, Ducheix S, Lippi Y, Lasserre F, Barquissau V, Régnier M, Lukowicz C, Benhamed F, Iroz A, Bertrand-Michel J, Al Saati T, Cano P, Mselli-Lakhal L, Mithieux G, Rajas F, Lagarrigue S, Pineau T, Loiseau N, Postic C, Langin D, Wahli W, Guillou H. Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut. 2016 doi:10.1136/gutjnl-2015-310798

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Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Shawn Je H, Maha AA, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S & Wahli W. Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals. Scientific Reports | 6:20127 | DOI: 10.1038/srep20127.

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Norton L, Lindsay Y, Deladeriere A, Chessa T, Guillou H, Suire S, Lucocq J, Walker S, Andrews S, Segonds-Pichon A, Rausch O, Finan P, Sasaki T, Du CJ, Bretschneider T, Ferguson GJ, Hawkins PT, Stephens L. Localizing the lipid products of PI3Kγ in neutrophils. Adv Biol Regul. 2016, 60:36-45.

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Pierron A, Mimoun S, Murate LS, Loiseau N, Lippi Y, Bracarense AF, Liaubet L, Schatzmayr G, Berthiller F, Moll WD, Oswald IP. Intestinal toxicity of the masked mycotoxin deoxynivalenol-3-β-D-glucoside. Arch Toxicol. 2016. In Press. PMID: 26404761.

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Tan CK, Wahli W. A trilogy of glucocorticoid receptor actions. Proc Natl Acad Sci U S A. 2016 Jan 20. PMID:26792523

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2015

Loiseau N, Polizzi A, Dupuy A, Therville N, Rakotonirainy M, Loy J, Viadere JL, Cossalter AM, Bailly JD, Puel O, Kolf-Clauw M, Bertrand-Michel J, Levade T, Guillou H, Oswald IP. New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver. Arch Toxicol. 2015, 89(9):1619-29.

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Garbacz WG, Huang JT, Higgins LG, Wahli W, Palmer CN. PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice. PPAR Res. 2015;2015:927057.

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Marmier S, Dentin R, Daujat-Chavanieu M, Guillou H, Bertrand-Michel J, Gerbal-Chaloin S, Girard J, Lotersztajn S, Postic C. Novel role for ChREBP in the control of ethanol metabolism and susceptibility to binge drinking. Hepatology. 2015, 62(4):1086-100.

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Chalouati H, Boutet E, Metais B, Fouche E, Ben Sâad MM, Gamet-Payrastre L. DNA damage and oxidative stress induced at low doses by the fungicide hexachlorobenzene in human intestinal Caco-2 cells. Toxicol Mech Methods. 2015 Sep 12:1-11.

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Tremblay-Franco M, Zerbinati C, Pacelli A, Palmaccio G, Lubrano C, Ducheix S, Guillou H, Iuliano L. Effect of obesity and metabolic syndrome on plasma oxysterols and fatty acids in human. Steroids. 2015, 99(Pt B):287-92.

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Gobbetti T, Ducheix S, le Faouder P, Perez T, Riols F, Boue J, Bertrand-Michel J, Dubourdeau M, Guillou H, Perretti M, Vergnolle N, Cenac N. Protective effects of n-6 fatty acids-enriched diet on intestinal ischemia/reperfusion injury involve lipoxin A4 and its receptor. Br J Pharmacol. 2015, 172(3):910-23.

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Roux PF, Boitard S, Blum Y, Parks B, Montagner A, Mouisel E, Djari A, Esquerré D, Désert C, Boutin M, Leroux S, Lecerf F, Le Bihan-Duval E, Klopp C, Servin B, Pitel F, Duclos MJ, Guillou H, Lusis AJ, Demeure O, Lagarrigue S. Combined QTL and Selective Sweep Mappings with Coding SNP Annotation and cis-eQTL Analysis Revealed PARK2 and JAG2 as New Candidate Genes for Adiposity Regulation. G3 (Bethesda). 2015, 5(4):517-29.

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Montagner A, Wahli W, Tan NS. Nuclear receptor peroxisome proliferator activated receptor (PPAR) β/δ in skin wound healing and cancer. Eur J Dermatol. 2015 Apr;25 Suppl 1:4-11.

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2014

Marmugi A, Lasserre F, Beuzelin D, Ducheix S, Huc L, Polizzi A, Chetivaux M, Pineau T, Martin P, Guillou H, Mselli-Lakhal L. Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycemia and hypercholesterolemia in mice. Toxicology. 2014, 325:133-43.

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Mahfouz R, Khoury R, Blachnio-Zabielska A, Turban S, Loiseau N, Lipina C, Stretton C, Bourron O, Ferré P, Foufelle F, Hundal HS, Hajduch E. Characterising the Inhibitory Actions of Ceramide upon Insulin Signaling in Different Skeletal Muscle Cell Models: A Mechanistic Insight. PLoS One. 2014, 9(7):e101865.

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Montagner A, Delgado M, Tallichet-Blanc C, Soon KJ Chan, Ming K Sng, Mottaz H, Degueurce G, Lippi Y, Moret C, Baruchet M, Antsiferova M, Werner S, Hohl D, A Saati T, Farmer PJ, Nguan S Tan, Michalik L, Wahli W. Src is activated by the nuclear receptor peroxisome proliferator‐activated receptor b/d in ultraviolet radiation‐induced skin cancer.EMBO Mol. Med. 2014, 6(1):80-98.

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Ellero-Simatos S, Fleuren WWM, Bauerschmidt S, Dokter WHA, Toonen EJM. Identification of gene signatures for prednisolone-induced metabolic dysfunction in collagen-induced arthritis mice. Pharmacogenomics. 2014, 15(5):629-41.

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Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sànchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R; Pharmacometabolomics Research Network.Pharmacometabolomics Reveals That Serotonin Is Implicated in Aspirin Response Variability. CPT Pharmacometrics Syst. Pharmacol. 2014; 3:e125.

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Mansour SA, Gamet-Payrastre L. Ameliorative effect of vitamin E to mouse dams and their pups following exposure of mothers to chlorpyrifos during gestation and lactation periods. Toxicol Ind Health. 2014 Sep 18. pii: 0748233714548207.

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Ilboudo S, Fouché E, Rizzati V, Toeb AM, Gamet-Payrastre L, Guissou PI. In vitro impact of five pesticides alone or in combination on human intestinal cell line Caco-2. Toxicology Reports 1. 2014, 474-489.

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Abdul-Wahed A, Gautier-Stein A, Casteras S, Soty M, Roussel D, Romenstaing C, Guillou H, Tourette JA, Pleche N, Zitoun C, Gri B, Sardella A, Rajas F, Mithieux G. A link between hepatic glucose production and peripheral energy metabolism via hepatokines. Molecular Metabolism. 2014, 3(5):531-43.

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2013

Loiseau N, Obata Y, Moradian S, Sano H, Yoshino S, Aburai K, Takayama K, Sakamoto K, Holleran WM, Elias PM, Uchida Y. Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis. J. Dermatol. Sci. 2013, 72(3):296-303.

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Guellich A, Damy T, Conti M, Claes V, Samuel JL, Pineau T, Lecarpentier Y, Coirault C. Tempol prevents cardiac oxidative damage and left ventricular dysfunction in the PPAR-α KO mouse. Am J Physiol Heart Circ Physiol. 2013, 304(11):H1505-12.

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Roques BB, Leghait J, Lacroix MZ, Lasserre F, Pineau T, Viguié C, Martin PG. The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism. Biochem. Pharmacol. 2013, 86(7):997-1039

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Ramamonjisoa N, Ratiney H, Mutel E, Guillou H, Mithieux G, Pilleul F, Rajas F, Beuf O, Cassavila S.In vivo hepatic lipid quantification using MRS at 7T in a mouse model of glycogen storage disease. J. Lipid Res. 2013, 54(7):2010-22.

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Ducheix S, Montagner A, Theodorou V, Ferrier L, Guillou H. The Liver X Receptor: a master regulator of the gut-liver axis and a target for Non Alcoholic Fatty Liver Disease. Biochem. Pharmacol. 2013, 86(1):96-105.

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Guillou H, Postic C. Atteintes hépatiques: Quels sont leurs déterminants nutritionnels? Diabète & Obésité. 2013, 8: 2-6.

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Ducheix S, Montagner A, Polizzi A, Lasserre F, Marmugi A, Bertrand-Michel J, Podechard N, Al Saati T, Chétiveaux M, Baron S, Mselli-Lakhal L, Costet P, Lobaccaro JMA, Pineau T, Theodorou V, Postic C, Martin PG, Guillou H. Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the Liver X Receptor. J Hepatol. 2013, 58(5):984-92.

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Montagner A, Wahli W. Contributions of Peroxisome Proliferator Activated Receptor b/d to skin health and disease. Biomol. Concepts 2013, 4:53-64.

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Ducheix S, Podechard N, Lasserre F, Polizzi A, Pommier A, Murzilli S, Di Lisio C, D'Amore S, Bertrand-Michel J, Montagner A, Pineau T, Loiseau N, Lobaccaro JM, Martin PG, Guillou H. A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα. Biochimie 2013, 95:556-67.

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2012

Kostadinova R, Montagner A, Gouranton E, Fleury S, Guillou H, Dombrowicz D, Desreumaux P, Wahli W. GW501516-activated PPARbeta/delta promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation. Cell & Biosciences 2012, 10;2(1):34.

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Benhamed F, Denechaud PD, Lemoine M, Robichon C, Moldes M, Bertrand-Michel J, Ratziu V, Serfaty L, Housset C, Capeau J, Girard J, Guillou H, Postic C. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J. Clin. Invest. 2012, 122:2176-94.

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Suire S, Lecureuil C, Anderson KE, Damoulakis G, Niewczas I, Davidson K, Guillou H, Pan D, Wu D, Clark J, Hawkins PT, Stephens L. GPCR activation of Ras and PI3Kg in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. The EMBO J. 2012, 31:3118-29.

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Roques BB, Lacroix MZ, Puel S, Gayrard V, Picard-Hagen N, Jouanin I, Perdu E, Martin PG, Viguié C. CYP450-Dependent Biotransformation of the Insecticide Fipronil into Fipronil Sulfone Can Mediate Fipronil-Induced Thyroid Disruption in Rats. Toxicol. Sciences 2012, 127:29-41.

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De Rocca Serra-Nédélec A, Edouard T, Tréguer K, Tajan M, Araki T, Dance M, Mus M, Montagner A, Tauber M, Salles JP, Valet P, Neel BG, Raynal P, Yart A. Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature. Proc. Natl. Acad. Sci. USA 2012, 109:4257-62.

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Marmugi A, Ducheix S, Lasserre F, Polizzi A, Paris A, Priymenko N, Bertrand-Michel J, Pineau T, Guillou H, Martin PGP, Mselli-Lakhal L. Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver. Hepatology 2012, 55:395-407.

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Brunner JM, Plattet P, Doucey MA, Rosso L, Curie T, Montagner A, Wittek R, Vandelvelde M, Zurbriggen A, Hirling H, Desvergne B. Morbillivirus glycoprotein expression induces ER stress, alters Ca2+ homeostasis and results in the release of vasostatin. PLOS ONE. 2012, 7:e32803.

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Annaházi A, Dabek M, Gecse K, Salvador-Cartier C, Polizzi A, Rosztóczy A, Róka R, Theodorou V, Wittmann T, Bueno L, Eutamene H. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain. Neurogastroenterol. Motil. 2012, 24:76-85.

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Gauthier T, Wang X, Sifuentes Dos Santos J, Fysikopoulos A, Tadrist S, Canlet C, Artigot MP, Loiseau N, Oswald IP, Puel O. Trypacidin, a Spore-Borne Toxin from Aspergillus fumigatus, Is Cytotoxic to Lung Cells. PLOS ONE. 2012, 7:e29906.

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Ménez C, Mselli-Lakhal L, Foucaud-Vignault M, Balaguer P, Alvinerie M, Lespine A. Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line. Biochem. Pharmacol. 2012, 83:269-78.

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2011

Foucaud-Vignault M, Soayfane Z, Ménez C, Bertrand-Michel J, Martin PGP, Guillou H, Collet X, Lespine A. P-glycoprotein dysfunction contributes to hepatic steatosis and obesity in mice. PLOS ONE 2011, 6(9):e23614.

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El Kochairi I, Montagner A, Rando G, Lohmann C, Matter CM, Wahli W. Beneficial effects of combinatorial micronutrition on body fat and atherosclerosis in mice. Cardiovascular Research 2011, 91:732-741.

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Ducheix S, Lobacarro JMA, Martin PG,Guillou H. Liver X Receptor: an oxysterol sensor and a major player in the control of lipogenesis. Chem. Phys. Lipids 2011, 164:500-14.

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Demeure O, Lecerf F, Duby C, Desert C, Ducheix S, Guillou H, Lagarrigue S. Regulation of LPCAT3 by LXR. Gene 2011, 470:7-11.

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Kulkarni S, Sitaru C, Jakus Z, Anderson KE, Damoulakis G, Davidson K, Hirose M, Juss J, Oxley D, Chessa TA, Ramadani F,Guillou H, Segonds-Pichon A, Fritsch A, Jarvis GE, Okkenhaug K, Ludwig R, Zillikens D, Mocsai A, Vanhaesebroeck B, Stephens LR, Hawkins PT. PI3K{beta} Plays a Critical Role in Neutrophil Activation by Immune Complexes. Science Signaling 2011, 12;4(168):ra23.

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Bessadok A, Garcia E, Jacquet H, Martin S, Garrigues A,Loiseau N, Andre F, Orlowski S, Vivaudou M.Recognition of sulfonylurea receptor (ABCC8/9) ligands by the multidrug resistance transporter P-glycoprotein (ABCB1): Functional similarities based on common structural features between two multispecific ABC proteins. J. Biol. Chem. 2011, 286:3552-69.

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Perrin L, Loiseau N, André F, Delaforge M. Metabolism of N-methyl-amide by cytochrome P450s: formation and characterization of highly stable carbinol-amide intermediate. FEBS J. 2011, 278:2167-78.

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Aburai K, Yoshino S, Sakai K, Sakai H, Abe M, Loiseau N, Holleran W, Uchida Y, Sakamoto K. Physicochemical analysis of liposome membranes consisting of model lipids in the stratum corneum. J. Oleo Sci. 2011, 60(4):197-202.

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Ducrot C, Bed'hom B, Béringue V, Coulon JB, Fourichon C, Guérin JL, Krebs S, Rainard P, Schwartz-Cornil I, Torny D, Vayssier-Taussat M, Zientara S, Zundel E, Pineau T. Issues and special features of animal health research. Vet Res. 2011 Aug 24;42:96.

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Dabek M, Ferrier L, Annahazi A, Bézirard V, Polizzi A, Cartier C, Leveque M, Roka R, Wittmann T, Theodorou V, Bueno L. Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: Role of cathepsin G and protease-activated receptor-4. Inflamm. Bowel Dis. 2011, 17:1409-14

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Zadravec D, Tvrdik P, Guillou H, Haslam R, Kobayashi T, Napier JA, Capecchi MR, Jacobsson A. ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice. J. Lipid Res. 2011, 52:245-55.

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Olivier I, Theodorou V, Valet P, Castan-Laurell I, Guillou H, Bertrand-Michel J, Cartier C, Bézirard V, Ducroc R, Segain JP, Portier G, Kirzin S, Moreau J, Duffas JP, Ferrier L, Eutamène H. Is Crohn’s creeping fat an adipose tissue? Inflamm. Bowel Dis. 2011, 17:747-57.

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Guelzim N, Mariotti F, Martin PG, Lasserre F, Pineau T, Hermier D.A role for PPARα in the regulation of arginine metabolism and nitric oxide synthesis. Amino Acids 2011, 41:969-79.

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2010

Zadravec D., Brolinson A., Fisher RM, Carneheim C, Csikasz RI, Bertrand-Michel J, Borén J, Guillou H, Rudling M, Jacobsson A.Ablation of the very long chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity. FASEB J. 2010 24:4366-77

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Chamouton J, Hansmannel F, Bonzo JA, Clémencet MC, Chevillard G, Battle M, Martin P, Pineau T, Duncan S, Gonzalez FJ, Latruffe N, Mandard S, Nicolas-Francès V. The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual Control of PPARα and HNF4α in the Liver. PPAR Research 2010, 2010:352957.

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Montfort A, Martin PG, Levade T, Benoist H, Ségui B. FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling. J. Leukoc. Biol. 2010, 88:897-903.

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Dray C, Debard J, Jager, Disse E, Daviaud D, Martin P, Attané C, Wanecq E, Guigné C, Bost F, Tanti JF, Laville M, Vidal H, Valet P, Castan-Laurell I. Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans. Am. J. Physiol. Endocrinol. Metab. 2010, 298:E1161-9.

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Breuker C, Moreau A, Lakhal L, Tamasi V, Parmentier Y, Meyer U, Maurel P, Lumbroso S, Vilarem MJ, Pascussi JM. Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). Endocrinology 2010, 107:1653-61.

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Braniste V, Jouault A, Gaultier E, Polizzi A, Buisson-Brenac C, Leveque M, Martin PG, Theodorou V, Fioramonti J, Houdeau E. Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats. Proc. Natl. Acad. Sci. USA 2010, 107, 448-53.

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Giantin M, Lopparelli RM, Zancanella V, Martin PG, Polizzi A, Gallina G, Gottardo F, Montesissa C, Ravarotto L, Pineau T, Dacasto M. Effects of illicit dexamethasone upon hepatic drug metabolizing enzymes and related transcription factors mRNA and their potential use as biomarkers in cattle. J Agric. Food Chem. 2010, 58, 1342-49.

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Craig HE, Coadwell J, Guillou H, and Vermeren S. ARAP3 Binding to Phosphatidylinositol-(3,4,5)-Trisphosphate Depends on Nterminal Tandem PH Domains and Adjacent Sequences. Cell Signal. 2010, 22, 257-64.

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Guillou H, Zadravec D, Martin PG, Jacobsson A. The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice. Prog. Lipid Res. 2010, 49:186-99.

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Dupont J, Musnier A, Decourtye J, Boulo T, Lécureuil C, Guillou H, Valet S, Fouchécourt S, Pitetti JL, Nef S, Reiter E Crépieux P. FSH-stimulated PTEN activity accounts for the lack of FSH mitogenic effect in prepubertal rat Sertoli cells. Mol. Cell. Endocrinol. 2010, 315:271-6.

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2009

Demeure O, Duby C, Desert C, Assaf S, Hazard D, Guillou H, Lagarrigue S. Liver X Receptor Alpha Regulates Fatty Acid Synthase Expression in Chicken. Poult. Sci. 2009, 88: 2628-35.

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Artigot MP, Loiseau N, Laffitte J, Mas-Reguieg L, Tadrist S, Oswald IP, Puel O. Molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in biosynthesis of patulin in Aspergillus clavatus. Microbiology 2009, 155:1738-47.

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Montfort A, de Badts B, Douin-Echinard V, Martin PG, Iacovoni J, Nevoit C, Therville N, Garcia V, Bertrand MA, Bessières MH, Trombe MC, Levade T, Benoist H, Ségui B. FAN stimulates TNFalpha-induced gene expression, leukocyte recruitment, and humoral response. J. Immunol. 2009, 183: 5369-78.

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Musnier A., Heitzler D, Boulo T, Tesseraud S, Durand G, Lecureuil C, Guillou H, Poupon A, Reiter E, Crépieux P. Developmental regulation of p70 S6 kinase by a G protein-coupled receptor dynamically modelized in primary cells. Cell. Mol. Life Sci. 2009, 66:3487-503.

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Blavy P, Gondret F, Guillou H, Lagarrigue S, Martin PG, van Milgen J, Radulescu O,  Siegel A. A minimal model for hepatic fatty acid balance during fasting: Application to PPAR alpha-deficient mice. J. Theor. Biol. 2009, 261:266-78.

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González I, Dejean S, Martin PG, Gonçalvez O, Besse P, Baccini A. Highlighting Relationships Between Heteregeneous Biological Data Through Graphical Displays Based On Regularized Canonical Correlation Analysis. J. Biol. Syst. 2009, 17:173-199.

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Eveillard A, Mselli-Lakhal L, Mogha A, Lasserre F, Polizzi A, Pascussi JM, Guillou H, Martin PG, Pineau T. Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signaling pathway sensitive to phthalates. Biochem. Pharmacol. 2009, 77:1735-46.

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Le Cao KA, Martin PGP, Robert-Granie C, Besse P. Sparse canonical methods for biological data integration: application to a cross-platform study. BMC Bioinformatics 2009, 10, 34.

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Cantiello M, Giantin M, Carletti M, Lopparelli RM, Capolongo F, Lasserre F, Bollo E, Nebbia C, Martin PGP, Pineau T and Dacasto M. Effects of dexamethasone, administered for growth promoting purposes, upon the hepatic cytochrome P450 3A expression in the veal calf. Biochem. Pharmacol. 2009, 77:451-463.

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Eveillard A, Lasserre F, de Tayrac M, Polizzi A, Claus S, Canlet C, Mselli-Lakhal L, Gotardi G, Paris A,Guillou H, Martin PG, Pineau T. Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach. Toxicol. Appl. Pharmacol. 2009, 236:282-292.

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2008

Bellocq D, Molina J, Rathahao E, Canlet C, Tache S, Martin PG, Pierre F and Paris A. High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutation. Mutat. Res. 2008, 653:34-43.

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Erhouma E, Guiguen F, Chebloune Y, Gauthier D, Lakhal LM, Greenland T, JF Mornex, Leroux C, Alogninouwa T. Small ruminant lentivirus proviral sequences from wild ibexes in contact with domestic goats. J. Gen. Virol. 2008, 89:1478-84.

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González I, Déjean S, Martin PG, Baccini A. CCA: An R Package to Extend Canonical Correlation Analysis. J. Stat. Softw. 2008, 23(12).

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Lecarpentier Y, Krokidis X, Martin P, Pineau T, Hebert JL, Quillard J, Cortes-Morichetti M and Coirault C. Increased entropy production in diaphragm muscle of PPAR alpha knockout mice. J. Theor. Biol. 2008, 250:92-102.

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Giantin M, Carletti M, Capolongo F, Pegolo S, Lopparelli RM, Gusson F, Nebbia C, Cantiello M, Martin P, Pineau T, Dacasto M. Effect of breed upon cytochromes P450 and phase II enzyme expression in cattle liver. Drug Metab. Dispos. 2008, 36:885-893.

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Cantiello M, Carletti M, Dacasto M, Martin PG, Pineau T, Capolongo F, Gardini G, Nebbia C. Cytochrome P450 inhibition profile in liver of veal calves administered a combination of 17beta-estradiol, clenbuterol, and dexamethasone for growth-promoting purposes. Food Chem. Toxicol. 2008, 46:2849-55.

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Guillou H, Martin PG, Pineau T. Transcriptional regulation of hepatic fatty acid metabolism. Subcellular Biochemistry: Lipids in Health and Disease. P. J. Quinn and X. Wang, Eds. Springer. 2008, Vol 49: 3-47.

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2007

Mselli-Lakhal L, Guiguen F, Greenland T, Mornex JF and Chebloune Y. In vitro cross-species infections using a caprine arthritis encephalitis lentivirus carrying the GFP marker gene. J. Virol. Methods 2007, 143:11-15.

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Dejean S, Martin PG, Baccini A, Besse P. Clustering time-series gene expression data using smoothing spline derivatives. EURASIP J. Bioinform. Syst. Biol. 2007, 70561.

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Mazzucotelli A, Viguerie N, Tiraby C, Annicotte JS, Mairal A, Klimcakova E, Lepin E, Delmar P, Dejean S, Tavernier G, Lefort C, Hidalgo J, Pineau T, Fajas L, Clement K, Langin D. The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human white adipocytes. Diabetes 2007, 56:2467-75.

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Lespine A, Martin S, Dupuy J, Roulet A, Pineau T, Orlowski S, Alvinerie M. Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship. Eur. J. Pharm. Sci. 2007, 30:84-94.

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Gueugnon F, Gondcaille C, Leclercq S, Bellenger J, Bellenger S, Narce M, Pineau T, Bonnetain F, Savary S. Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene (ABCD2) independently of PPARalpha in rodents. Biochimie 2007, 89:1312-21.

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Guellich A, Damy T, Lecarpentier Y, Conti M, Claes V, Samuel JL, Quillard J, Hebert JL, Pineau T, Coirault C. Role of oxidative stress in cardiac dysfunction of PPARalpha-/- mice. Am. J. Physiol. Heart Circ. Physiol. 2007, 293:H93-H102.

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Petit V, Arnould L, Martin P, Monnot MC, Pineau T, Besnard P, Niot I. Chronic high-fat diet affects intestinal fat absorption and postprandial triglyceride levels in the mouse. J. Lipid Res. 2007, 48:278-287.

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Martin PG, Guillou H, Lasserre F, Dejean S, Lan A, Pascussi JM, Sancristobal M, Legrand P, Besse P,Pineau T. Novel aspects of PPARalpha-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study. Hepatology 2007, 45:767-777.

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Loiseau N, Debrauwer L, Sambou T, Bouhet S, Miller JD, Martin PG, Viadere JL, Pinton P, Puel O, Pineau T, Tulliez J, Galtier P, Oswald IP. Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance. Biochem. Pharmacol. 2007, 74:144-152.

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Villard PH, Caverni S, Baanannou A, Khalil A,Martin PG, Penel C, Pineau T, Seree E, Barra Y. PPARalpha transcriptionally induces AhR expression in Caco-2, but represses AhR pro-inflammatory effects. Biochem. Biophys. Res. Commun. 2007, 364:896-901.

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2006

Mselli-Lakhal L, Guiguen F, Greenland T, Mornex JF and Chebloune Y. Gene transfer system derived from the caprine arthritis-encephalitis lentivirus. J. Virol. Methods 2006, 136:177-184.

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Bassissi MF, Alvinerie M, Martin PG, Perret B and Lespine A. Influence of dyslipidemia on moxidectin distribution in plasma lipoproteins and on its pharmacokinetics. Pharm. Res. 2006, 23:2672-80.

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Lambert G, Jarnoux AL, Pineau T, Pape O, Chetiveaux M, Laboisse C, Krempf M, Costet P. Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor. Endocrinology 2006, 147:4985-95.

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2005

Pascussi JM, Robert A, Nguyen M, Walrant-Debray O, Garabedian M,Martin P, Pineau T, Saric J, Navarro F, Maurel P, Vilarem MJ. Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. J. Clin. Invest. 2005, 115:177-186.

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Gondcaille C, Depreter M, Fourcade S, Lecca MR, Leclercq S, Martin PG, Pineau T, Cadepond F, El Etr M, Bertrand N, Beley A, Duclos S, De Craemer D, Roels F, Savary S, Bugaut M. Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator. J. Cell Biol. 2005, 169:93-104.

pubmed

Martin PG, Lasserre F, Calleja C, Van Es A, Roulet A, Concordet D, Cantiello M, Barnouin R, Gauthier B, Pineau T. Transcriptional modulations by RXR agonists are only partially subordinated to PPARalpha signaling and attest additional, organ-specific, molecular cross-talks. Gene Expr. 2005, 12:177-192.

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Baccini A, Besse P, Déjean S, Martin PGP, Robert-Granié C, SanCristobal M. Stratégies pour l'analyse statistique de données transcriptomiques. J. Soc. Fr. Statistique 2005,146:5-44.

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Frédéric LASSERRE papers

before joining the lab
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Laila LAKHAL papers

before joining the lab
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Hervé GUILLOU papers

before joining the lab
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Nicolas LOISEAU papers

before joining the lab
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Alexandra MONTAGNER papers

before joining the lab
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Sandrine ELLERO-SIMATOS papers

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Laurence GAMET-PAYRASTRE papers

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