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Productions

 Original Articles in peer-reviewed journals

2014 (in progress)

  • Peyre L, Rouimi P, de Sousa G, Hélies C, Carré B, Barcellini S, Chagnon MC, Rahmani R. (2014). Comparative study of bisphenol A and its analogue bisphenol S on human hepatic cells: a focus on their potential involvement in nonalcoholic fatty liver disease. Food Chem Toxicol. 2014 [Epub ahead of print].
  • Sánchez-Rodríguez R, Torres-Mena JE, De la Luz Cruz M, Bernal-Ramos GA, Villa-Treviño S, Chagoya-Hazas V, García-Román R, Rouimi P, Del Pozo-Yauner L, Meléndez-Zajgla J, Pérez-Carreón J. (2014). Increased expression of prostaglandin reductase 1 in hepatocellular carcinomas from clinical cases and experimental tumors in rats. Int J Biochem Cell Biol. May 20. pii: S1357-2725(14)00175-7. doi: 10.1016/j.biocel.2014.05.017.
  • De Sousa G, Nawaz A, Cravedi JP, Rahmani R. (2014). A Concentration Addition Model to Assess Activation of the Pregnane X Receptor (PXR) by Pesticide Mixtures Found in the French Diet. Toxicological Sciences. 2014 (in press)
  • Peyre L, Zucchini-Pascal N, de Sousa G, Luzy AP, Rahmani R. (2014). Potential involvement of chemicals in liver cancer progression: an alternative toxicological approach combining biomarkers and innovative technologies. Toxicol In Vitro. 2014 (in press).
  • Héliès-Toussaint C, Peyre L, Costanzo C, Chagnon MC, Rahmani R. (2014). Is bisphenol S a safe substitute for Bisphenol A in terms of metabolic modulation? An in vitro study. Toxicol App Pharmaco. TAP. 2014. (in press)

2013

  • Barcellini-Couget S, Pery  A, Rahmani R. (2013). Technologie d’impédance cellulaire en temps réel pour l’étude des effets aigus et chroniques de composés et mélanges sur la lignée HepaRG. Colloque ARET. Modèles biologiques, modèles mathématiques : Avancées et perspectives en Toxicologie et Ecotoxicologie. Actes du Congrès, pp6-8
  • Barcellini-Couget S, de Sousa G, Rahmani R. (2013). The use of real-time analyser (RTCA) in in vitro toxicology. Tox Letters. Vol. 221S, p163.
  • Crépet A, Héraud F, Béchaux C, Gouze ME, Suzanne, Pierlot S, Fastier A, Leblanc JC, Ludovic Le Hégarat L, Takakura N, Fessard F, Tressou J, Maximilien R, Nawaz A, de Sousa G, Zucchini-Pascal N, Rahmani R, Audebert M, Graillot V, Cravedi JP. (2013). The PERICLES research program: an integrated approach to characterize the combined effects of mixtures of pesticide residues to which the French population is exposed. Toxicology. 313(2-3):83-93.
  • de Sousa, Nawaz A, J.P. Cravedi, Rahmani R. (2013). Concentration addition model to assess activation of the Pregnane X receptor by pesticides mixtures found in the French diet. Tox Letters. Vol. 221S, p198.
  • Nawaz A, Razpotnik A, Rouimi P, de Sousa G, Cravedi JP, Rahmani R. (2013). Cellular impact of combinations of endosulfan, atrazine and chlorpyrifos on human primary hepatocytes and HepaRG cells after short and chronic exposures. Cell Biol Toxicol. 2013 Dec 17. [Epub ahead of print].
  • Peyre L, Zucchini-Pascal N, Rahmani R. (2013). Atrazine represses S100A4 gene expression and TPA-induced motility in HepG2 cells. Toxicol In Vitro. 6; 28(2):156-163.
  • Silvy F, Lissitzky Jc, Bruneau N, Zucchini N, Landrier Jf, Lombardo D, Verrando P. (2013).  Resistance to cisplatin-induced cell death conferred by the activity of organic anion transporting polypeptides (OATP) in human melanoma cells. Pigment Cell Melanoma Res. 26: 592-596.
  • Zucchini-Pascal N, Peyre L, Rahmani R. (2013). Crosstalk between beta-catenin and snail in the induction of epithelial to mesenchymal transition in hepatocarcinoma: role of the ERK1/2 pathway. Int J Mol Sci. 14(10):20768-92.

2012

  • Peyre L, Zucchini-Pascal N, de Sousa G, Rahmani R. (2012). Effects of endosulfan on hepatoma cell adhesion: epithelial-mesenchymal transition and anoikis resistance. Toxicology. 300 (1-2), 19-30.
  • Rouimi P, Zucchini-Pascal N, Dupont G, Razpotnik A, Fouché E, de Sousa G, Rahmani R. (2012). Impacts of low doses of pesticide mixtures on liver cells defense systems. Toxicol in Vitro. 26, 718–726.
  • Zucchini-Pascal N, Peyre L, de Sousa G, Rahmani R. (2012). Organochlorine pesticides induce epithelial to mesenchymal transition of human primary cultured hepatocytes. Food Chem Toxicol. 50(11), 3963-3970.
  • Cravedi J.P, Audebert M, Debrauwer L, E Jamin E, Payrastre L, Rahmani R, Canivenc MC. (2012) Les mélanges de contaminants: est-on capable d’en évaluer les risques ? Innovations Agronomiques. 24, 49-56.
  • Vásquez-Garzón VR, Rouimi P, Jouanin I, Waeg G, Zarkovic N, Villa-Treviño S, Guéraud F. (2012). Evaluation of three simple direct or indirect carbonyl detection methods for characterization of oxidative modifications of proteins. Toxicol Mech Methods. 22(4):296-304. (IF 1.367, Q3).

2011

  • Zucchini-Pascal N, de Sousa G, Pizzol J, Rahmani R. (2011). Molecular investigation of the effects of lindane in rat hepatocytes: microarray and mechanistic studies. Food Chem Toxicol. 49(12):3128-35. (IF : 3.21, Food Science & Technology 12/124, Q1).
  • Dumont C, Perdu E, de Sousa G, Debrauwer L, Rahmani R, Cravedi JP, Chagnon MC. Bis(hydroxyphenyl)methane-bisphenol F-metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes. (2011). Drug Chem Toxicol. 34(4):445-53. (IF : 1.06, Pharmacology & Pharmacy 190/261, Q3).
  • Marteau C, Chevolleau S, Jouanin I, de Sousa G, Rahmani R, Antignac J-P, Lebizec B, Zalko D, Debrauwer L. (2011). Development of a liquid chromatography/ atmospheric pressure photo-ionization high-resolution mass spectrometry analytical method for the simultaneous determination of polybrominated diphenyl ethers and their metabolites: application to BDE-47 metabolism in human hepatocytes. Rapid Commun Mass Spectrom. 26(6): 599-610. (IF : 2.61, Spectroscopy 13/43, Q2).
  • Dumont C, Perdu E, de Sousa G, Debrauwer L, Rahmani R, Cravedi JP, Chagnon MC. Bis(hydroxyphenyl)methane-bisphenol F-metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes. (2011). Drug Chem Toxicol. 34(4):445-53.

2010

  • Iannelli A, de Sousa G, Zucchini N, Saint-Paul M, Gugenheim J, Rahmani R. Antiapoptotic prosurvival effect of clotrimazole in a normothermic ischemia reperfusion injury animal model. J Surg Res 2010 (Apr 7). [Epub ahead of print].
  • Zucchini-Pascal N, de Sousa G, Pizzol J, Rahmani R. PXR activation protects rat hepatocytes from DCA-induced apoptosis. Liver Int 2010, 30, 284-297.

2009

  • Baldini E, Cursio R, de Sousa G, Margara A, Honiger J, Saint-Paul MC, Bayer P, Raimondi V, Rahmani R, Mouiel J, Gugenheim J. (2009). Cryopreserved porcine hepatocytes: expression and induction of cytochrome P450, isoform CYP2E1. Transplantation Proceedings. 41(4), 1367-1369.
  • Iannelli A, de Sousa G, Zucchini N, Saint-Paul M, Gugenheim J, Rahmani R. (2009) Clotrimazole protects the liver against normothermic ischemia-reperfusion injury in the rat. Transplantation Proceedings. 1(0), 4099-4104.
  • Zucchini-Pascal N, de Sousa G, Rahmani R. (2009). Lindane and cell death: at the crossroads between apoptosis, necrosis and autophagy. Toxicology. 256(1-2), 32–41.

Reviews

1. In the framework of "Groupe d’Innovation Non Clinique" (GTINC) of the ANSM, R. Rahmani has contributed to the following collective reviews:

J.R. Claude, L. Domenjoud, E. Fattal, J. Guillemain, A. Guillouzo , S. Le Crom, A. Le Pape, S. Lerondel, P. Lescuyer, F. Morel, M. Pallardy, G. Peltre, C. Pineau, T. Rabilloud, R. Rahmani, D. Sauvaire, D. Tremblay Position paper on proteomics: “Le point sur l'analyse protéomique dans l'industrie pharmaceutique: le défi analytique n'est-il pas tout simplement trop grand ? (2009);
•    Concept paper on Toxicology imaging (2009);
•    Recommandations for toxicological evaluation of nanoparticle medicinal products (2011);
•    Concept paper: Le sequençage a haut debit: Methodes et enjeux en medecine, pharmacologie et Toxicologie (2011).
•    Position paper on Immunotoxicology (2011).
•    Concept paper: Quantification de Protéines Spécifiques par SRM/MRM, perspectives d’Application et Limitations Actuelles (2012).

2. In the framework of ANSES, R. Rahmani has contributed to the collective report : “Valeurs Toxicologiques de Référence pour les Substances Cancérogènes” (Marsh 2010, 100 pages).

3. In the framework of Comité d’Experts de l’INSERM: “Pesticides et leur effets sur la santé” (1000 pages), R. Rahmani wrote the chapter on  “Mécanismes d’action des pesticides et cancer”, p609-713 & “Effets mélanges”, p845-848 (2013). Moreover, these works were presented on behalf of this committee at several occasions :

  • Sénat (June 2012),
  • Assemblée Nationale (Colloques Pesticides, Santé et Biodiversité, January 2014),
  • Ministère de l’Ecologie – Plan EcoPhyto (September & November 2103, January 2014),

and in many other occasions in 2012-2014 (Chambre d’agriculture du Limousin, du Poitou-Charente, de Haute-Saône,  4ième Congrès National Santé Environnement de la Société Française Santé Environnement, Réunion SFMT Société Française de Médecine du Travail, 4ième congrès du « Groupe Français de Pesticides », Journée Régionale de la Santé au Travail, Séminaire scientifique InVS commission supérieure des maladies professionnelles…).

Books

J.R. Claude, L. Domenjoud, E. Fattal, J. Guillemain, A. Guillouzo , S. Le Crom, A. Le Pape, S. Lerondel, P. Lescuyer, F. Morel, M. Pallardy, G. Peltre, C. Pineau, T. Rabilloud, R. Rahmani, D. Sauvaire, D. Tremblay: Recommendations for Toxicological Evaluation of Nanoparticle Medicinal Products. In International pharmaceutical products registration, Second Edition, Vol.200, August 2009, p755-761 by Anthony F.Cartwright, Brian R.Matthews (Editor).

Protocols

Bratt, P., Valmalette, J. C., Mertz, C., de Sousa, G., Dombrovsky, A., Capovilla, M., and Robichon, A. (2012) Analysis of carotenoid compounds in aphids by Raman imaging and mass spectrometry. Protocol Exchange. doi:10.1038/protex.2012.047.

International Meetings & Congresses

Oral Communications & Invited Conferences

  • Rahmani R. 2009. PXR: a physiological xenosensor at the cross-roads between detoxication and cell death processes. Hofmann-La Roche Research Institute. 18-19 Mai 2009, Basel. Suisse.
  • Rahmani R. 2010. Health Assessment of Pesticides: Cellular, Molecular and Genomic Impacts. First European Doctoral College on Environemental and Health (EDCEH). 11 Juin, 2010.  Rennes.
  • Rahmani R. 2010. Potential applications of xCELLigence System in xenobiotic‘s hepatotoxicity studies 1st European xCELLigence System User Conference. 26 Mai, 2010. Munich.
  • Rahmani R. 2010. Impedance-based label-free xCELLigence system: an innovative tool towards a more explanatory and predictive toxicology". Roche Diagnostics, Applied Science Business Unit, Cytomics Team. Mai 2010. Tokyo, Japon.
  • Rahmani R. 2011. Real time cellular impedance. An innovative approach in predictive toxiccology. 6ième Rencontres de l’Innovation. 30 Novembre 2011 - Palais Brongniart de Paris.
  • Rahmani R. 2013. A Concentration Addition Model to Assess Activation of the Pregnane X Receptor (PXR) by Pesticide Mixtures Found in the French Diet. Chemical mixtures : challenges for research and risk assessment ANSES Conference. Maison de la RATP. Paris, 10 Décembre 2013.
  • Rahmani R, Barcellini S. 2009. Tests innovants : Une alternative à l’expérimentation animale dans le contexte de REACH. Forum RSE PACA. 13 Mars. Marseille.
  • de Sousa G, Barcellini S, Rahmani R. 2009. xCELLigence: a new tool for modern toxicology. Séminaire Roche, Juillet 2009, Ste Maxime.
  • Rahmani R. 2010. L’évaluation des risques environnementaux et sanitaires des pesticides. Atelier Scénarri d’Exposition: Application de Reach. organisée par le PRIDES NOVACHIM. 30 Septembre, 2010. Europôle de l’Arbois Aix-en-Provence.
  • Rahmani R. 2012. Le risque «pesticicides» : Contexte et approches méthodologiques. Colloque CRITT Chimie : éviter les risques liés aux matières premières. Novembre 2012. Avignon.
  • Rahmani R et Barcellini-Couget S. 2013. La mesure d’impédance cellulaire en temps réel : un nouvel outil en pharmaco-toxicologie prédictive. Modèles biologiques, modèles mathématiques : Avancées et perspectives en Toxicologie et Ecotoxicologie. Université Paris Diderot. Paris. Colloque ARET, 20-21 Juin 2013.
  • Rahmani R. 2013. Etude in vitro des impacts cellulaires et moléculaires de mélanges de pesticides. Journées Francophones de Nutrition. Bordeaux, 12 Décembre 2013.
  • Teng S, Barcellini B, Beaudouin R, Rahmani R, Pery A. Multi-scale modeling: prediction of in vivo hepatotoxicity from in vitro data. Congrés QSAR 2014 - 16-20 juin 2014 - Milan - Communication orale
  • Roques B, Lacroix M, S. Puel, Kesteman A-S, Jouanin I, Perdu E, de Sousa G, Rahmani R, Gayrard V, Picard-Hagen N, Viguié C. Journées d’Animation Scientifique du Département Santé Animale. Fréjus. 2011.
  • Barcellini-Couget S, de Sousa G, Pery A, Rahmani R. Impédance en temps réel, une Approche de Toxicologie Cellulaire Prédictive. Colloque national du réseau ANTIOPES «Ecotoxicologie et Toxicologie environnementale : nouveaux concepts, nouveaux outils», 19 et 20 Mars 2012. Avignon.
  • Verrando P, de Sousa G,  Peyre L,  Rahmani R. Le pesticide trans-nonachlore réprime plusieurs microARN du mélanocyte humain normal : rôle potentiel dans la transformation maligne dépendante de l'environnement. Congrès  Annuel de recherche Dermatologique (CARD), Paris, 10-11 décembre 2013.  Abstr. in Annal. Dermatol. Venereol.
  • Héliès C, Peyre L, Costanzo C, Chagnon MC, Rahmani R. BPS as a substitute to BPA – an In vitro biological and metabolic comparative study. Journée « Nutrition et Cancer » CLARA-NACRe, 18 juin 2014, Lyon.

Posters

  • Barcellini-Couget S., G. de Sousa, N. Zucchini, L. Peyre, R. Rahmani. 2010. Real Time Cellular Impedance: a new tool in toxicology ? French anual congress of Cellular Pharmaco-Toxicology Society (SPTC), 18-19 Mai. Paris.
  • Peyre L., N. Zucchini-Pascal, R. Rahmani. 2010. Epithelial-mesenchymal transition in hepatoblastoma cells: implication of Erk1/2 pathway and Snail. Congress of the Cellular Pharmaco-Toxicology Society (SPTC). 18-19 Mai. Paris.
  • Barcellini S, de Sousa G, Rahmani R. Analyse en temps réel sur modèles in vitro Congrès annuel de la SPTC (Société de Pharmaco-Toxicologie Cellulaire) "La peau et ses alternatives". 19-20 Mai 2011, Toulouse, France. Awards for the best Poster.
  • Rouimi P, Zucchini N, Dupont G, Fouché E, de Sousa G, Rahmani R. Impact sur la cellule hépatique d'exposition à des doses sub-toxiques de trois pesticides seuls ou en mélange. 41ème Congrès du Groupe Français des Pesticides. 25-27 Mai 2011. Orléans.
  • Costanzo C, Rouimi P, de Sousa G, Chagnon MC, Rahmani R, Helis-Toussaint C. BPS a good alternative to BPA ? Metabolic studies of BPA and BPS in hepatocytes and adipocytes. MELBA Project. Recent advances on the environmental and health effects of endocrine disrupters. 11-12 Décembre 2012. Paris.
  • Ivry-Del Moral L, Le Corre L, Rahmani R, Helies C, Chagnon M.C. Effects of Bisphenol A and its substitutes on the proliferation and differenciation in Caco-2 intestine cell model. MELBA Project. Recent advances on the environmental and health effects of endocrine disrupters. 11-12 Décembre 2012. Paris.
  • Barcellini‐Couget S, Perry A, Rahmani R. Impédance cellulaire en temps réel: Evaluation toxicologique de composés et de mélanges. Modèles biologiques, modèles mathématiques:Avancées et perspectives en Toxicologie et Ecotoxicologie. Université Paris Diderot. Colloque ARET, 20-21 Juin 2013. Paris.
  • Teng S, Beaudouin R, Barcellini S, Rahmani R, Pery A. Modèles mathématiques pour l’analyse des données de viabilité cellulaire issue d’impédancemétrie : application à l’étude des effets de la coumarine sur cellules hépatiques. Les nouvelles approches en évaluation du risque: TTC, MOA, MOS, MOE, WOE, QSAR et Read Across. Congrès SFTox. 14-15 Novembre 2013. Paris.
  • Braud L, de Sousa G, Peyre L, Zeil JM, R. Rahmani, Maixent JM. Hao Ling pu-erh tea attenuates lipid accumulation in primary culture rat hepatocytes. Congrés de la SFC. 24-25 Avril 2014. Strasbourg.
  • Peyre L, Héliès-Toussaint C, Costanzo C, de Sousa, Patrick Rouimi, Benjamin Carré, Sylvie Barcellini, Marie-Christine Chagnon, Roger Rahmani. Perturbateurs endocriniens, enjeux industriels, de santé et d’environnement. An in vitro evaluation of bisphenols focusing on hepatotoxicity and obesity under environmental levels of exposition. 8 juillet 2014, Parc de Technologique Biocitech, Romainville.