Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free: https://www.ghostery.com/fr/products/

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site: http://www.youronlinechoices.com/fr/controler-ses-cookies/, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Realytics
Google Analytics
Spoteffects
Optimizely

Targeted advertising cookies

DoubleClick
Mediarithmics

The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at cil-dpo@inra.fr or by post at:

INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu INRA logo envt small Logo INP-EI Purpan Logo UPS-Tlse3

Home page

Zone de texte éditable et éditée et rééditée

Productions

Original Articles (NGN team members in bold ; members of other Toxalim teams in italic)

2017 (in progress)

Bettini S, Boutet-Robinet E, Cartier C,Coméra C, Gaultier E, Dupuy J, Naud N, Taché S, Grysan P, Reguer S, Thieriet N, Réfrégiers M, Thiaudière D, Cravedi JP, Carrière M, Audinot JN, Pierre FH, Guzylack-Piriou L, Houdeau E. Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon. Sci Rep 2017;7:40373.

pubmed

Olier M, Sekkal S, Harkat C, Eutamène H, Theodorou V. Evaluation of reticulated gelatin-hibiscus-propolis against intestinal commensal bacteria with uropathogenic potential. Future Microbiol 2017 (in press)

2016

Annaházi A, Ábrahám S, Farkas K, Rosztóczy A, Inczefi O, Földesi I, Szűcs M, Rutka M, Theodorou V, Eutamene HBueno L, Lázár G, Wittmann T, Molnár T, Róka R. A pilot study on faecal MMP-9: a new noninvasive diagnostic marker of colorectal cancer. Br J Cancer 2016;114(7):787-92. 

pubmed

Bessette C, Benoit B, Sekkal S, Bruno J, Estienne M, Leonil J, Ferrier L, Théodorou V, Plaisancié P. Protective effect of β-casofensin, a bioactive peptide from bovine β-casein, against indomethacin-induces intestinal lesions in rats. Mol Nutr Food Res 2016;60(4):823-33.

pubmed

Castelain M, Duviau MP, Oxaran V, Schmitz P, Cocaign-Bousquet M, Loubière P, Piard JC, Mercier-Bonin M. Oligomerized backbone pilin helps piliated Lactococcus lactis to withstand shear flow. Biofouling. 2016;32(8):911-23.

pubmed

Castelain M, Duviau MP, Canette A, Schmitz P, Loubière P, Cocaign-Bousquet M, Piard JC, Mercier-Bonin M. The Nanomechanical Properties of Lactococcus lactis Pili Are Conditioned by the Polymerized Backbone Pilin. PLoS One 2016;11(3):e0152053.

pubmed

Eutamène H, Garcia-Rodenas CL, Yvon S, d'Aldebert E, Foata F, Berger B, Sauser J, Theodorou V, Bergonzelli G, Mas E. Luminal contents from the gut of colicky infants induce visceral hypersensitivity in mice. Neurogastroenterol Motil 2016 Dec 1. [Epub ahead of print]

pubmed

Guellerin M, Passerini D, Fontagné-Faucher, Robert H, Gabriel V, Loux V, Klopp C, Le Loir Y, Coddeville M, Daveran-Mingot ML, Ritzenthaler P, Le Bourgeois P. Complete Genome Sequence of Lactococcus lactis subsp. lactis A12, a Strain Isolated from Wheat Sourdough. Genome Announc 2016; 4 (5) :e00692.

pubmed

Miquel S, Martín R, Lashermes A, Gillet M, Meleine M, Gelot A, Eschalier A, Ardid D, Bermúdez-Humarán LG, Sokol H, Thomas M, Theodorou V, Langella P, Carvalho FA. Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models. Sci Rep 2016;6:19399.

pubmed

Radziwill-Bienkowska JM, Le DT, Szczesny P, Duviau MP, Aleksandrzak-Piekarczyk T, Loubière P, Mercier-Bonin M, Bardowski JK, Kowalczyk M. Adhesion of the genome-sequenced Lactococcus lactis subsp. cremoris IBB477 strain is mediated by specific molecular determinants. Appl Microbiol Biotechnol 2016;100(22):9605-9617.

pubmed

Rincel M, Lépinay AL, Delage P, Fioramonti JThéodorou V, Layé S, Darnaudéry M. Maternal high-fat diet prevents developmental programming by early-life stress. Transl Psychiatry 2016;6(11):e966.

pubmed

Soayfane Z, Tercé F, Cantiello M, Robenek H, Nauze M, Bézirard V, Allart S, Payré B, Capilla F, Cartier C, Peres C, Al Saati T, Theodorou V, Nelson DW, Yen CL, Collet X, Coméra C. Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane. Nutr Metab (Lond);2016;13:48. 

pubmed

Yvon S, Olier M, Leveque M, Jard G, Tormo H, Haimoud-Lekhal DA, Peter M, Eutamène H. Donkey milk consumption exerts anti-inflammatory properties by normalizing antimicrobial peptides levels in Paneth's cells in a model of ileitis in mice. Eur J Nutr 2016;Aug 31. [Epub ahead of print]

pubmed

Wang C, Zanna S, Frateur I, Despax B, Raynaud P, Mercier-Bonin M, Marcus P. BSA adsorption on a plasma-deposited silver nanocomposite film controls silver release: a QCM and XPS-based modelling. Surf Coat Technol 2016;307:1-8.

logo_sciencedirect

2015

Da Silva S, Robbe-Masselot C, Raymond A, Mercade-Loubière M, Salvador-Cartier C, Ringot B, Léonard R, Fourquaux I, Ait-Belgnaoui A, Loubière P, Théodorou V, Mercier-Bonin M. Spatial localization and binding of the probiotic Lactobacillus farciminis to the rat intestinal mucosa: influence of chronic stress. PLoS One 2015;10(9):e0136048

pubmed

Durand C, Pezet S, Eutamène H, Demarquay C, Mathieu N, Moussa L, Daudin R, Holler V, Sabourin JC, Milita F, François A, Théodorou V, Tamarat B, Benderitter M, Sémont A. Persistent visceral allodynia in rats exposed to colorectal irradiation is reverser by mesenchymal stromal cell treatment. Pain 2015;156(8):1465-76.

pubmed

Martín R, Miquel S, Chain F, Natividad JM, Jury J, Lu J, Sokol H, Theodorou V, Bercik P, Verdu EF, Langella P, Bermúdez-Humarán LG. Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model. BMC Microbiol 2015;15:67.

pubmed

Secher T, Payros D, Brehin C, Boury M, Watrin C, Gillet M, Bernard-Cadenat I, Menard S, Theodorou V, Saoudi A, Olier M, Oswald E. Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin. Infect Immun 2015;83(6):2420-9. 

pubmed

2014

Ménard SGuzylack-Piriou L, Lévêque M, Braniste V, Lencina C, Naturel M, Moussa L, Sekkal S, Harkat C, Gaultier EThéodorou VHoudeau E. Food intolerance at adulthood after perinatal exposure to the endocrine disruptor bisphenol A. FASEB J 2014;28(11):4893-900

pubmed

 

Da Silva S, Robbe-Masselot C, Ait-Belgnaoui A, Mancuso A, Mercade-Loubière M, Cartier CGillet M, Ferrier L, Loubière P, Dague E, Théodorou V, Mercier-Bonin M. Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment. Am J Physiol Gastrointest Liver Physiol 2014;307(4):G420-9

pubmed

Ménard S, Guzylack-Piriou L, Lencina C, Leveque M, Naturel M, Sekkal S, Harkat C, Gaultier E, Olier M, Garcia-Villar RTheodorou V, Houdeau E.Perinatal exposure to a low dose of bisphenol A impaired systemic cellular immune response and predisposes young rats to intestinal parasitic infection. PLoS One 2014;9(11):e112752.

pubmed

Moussaoui N, Braniste V, Ait-Belgnaoui A, Gabanou M, Sekkal S, Olier M, Théodorou VMartin PG, Houdeau E. Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats. PLoS One, 9(2):e88382

pubmed

Payros D, Sécher T, Boury M, Brehin C, Ménard S, Salvador-Cartier C, Ceevas-Ramos G, Watrin C, Marcq I, Nougayrède JP, Dubois D, Bedu A, Garnier F, Clermont O, Denamur E, Plaisancié P, Théodorou V, Fioramonti J, Olier M, Oswald E. Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis. Gut Microbes 2014;5(3):313-25

pubmed

Nébot-Vivinus M, Harkat C, Bzioueche H, Cartier C, Plichon-Dainese R, Moussa L, Eutamène H, Pishvaie D, Holowacz S, Seyrig C, Piche T, Théodorou V. A multispecies probiotic protects gut barrier function in experimental models. World J Gastroenterol 2014;20(22):6832-43

pubmed

Ait-Belgnaoui A, Colom A, Braniste V, Ramalho L, Marrot ACartier C, Houdeau EThéodorou V, Tompkins T. Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice. Neurogastroenterol Motil 2014;26:510-20

pubmed

Le Dréan G, Haure-Mirande V, Ferrier L, Bonnet C, Hulin P, De Coppet P, Segain JP. Visceral adipose tissue and leptin increase colonic epithelial tight-junction permeability via a RhoA-ROCK dependent pathway. FASEB J 2014;28:1059-70

pubmed

Olivier I, Théodorou V, Valet P, Castan-Laurell I, Ferrier L, Eutamène H. Modifications of mesenteric adipose tissue during moderate experimental colitis. Life Sci 2014;94:1-7

pubmed

Stockinger S, Albers T, Duerr CU, Ménard S, Pütsep K, Andersson M, Hornef MW. Interleukin-13-mediated Paneth cell degranulation and antimicrobial peptide release. J Innate Immun 2014;6:530-41

pubmed

Marcq I, Martin P, Payros D, Cuevas-Ramos G, Boury M, Watrin C, Nougayrède JP, Olier M, Oswald E. The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli. J Infect Dis 2014;210(2):285-94

pubmed

2013

Seyer A, Cantielo M, Bertrand-Michel J, Roques V, Nauze M, Bézirard V, Collet X, Touboul D, Brunelle A, Coméra C. Lipidomic and spatio-temporal imaging of fat by mass spectrometry in mice duodenum during lipid digestion. PLoS One 2013;8(4):e58224

pubmed

Ducheix S, Montagner A, Polizzi A, Lasserre F, Marmugi A, Bertrand-Michel J, Podechard N, Saati TA, Chétiveaux M, Baron S, Boué J, Dietrich G, Mselli-Lakhal L, Costet P, Lobaccaro JM, Pineau T, Theodorou V, Postic C, Martin PG, Guillou H. Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the Liver X Receptor. J Hepatol 2013 (in press).

pubmed

Petrella C, Giuli C, Broccardo M, Eutamene H, Cartier C, Leveque M, Bedini A, Spampinato S, Bueno L, Theodorou V, Improta G, Agostini S. Protective and worsening peripheral nociceptin/orphanin FQ receptor-mediated effect in a rat model of experimental colitis.  Pharmacol Res 2013;70(1):72-79.

pubmed

Moussa L, Bézirard V, Salvador-Cartier C, Bacquié V, Lencina C, Lévêque M, Braniste V, Ménard S, Theodorou V, Houdeau E. A low dose of fermented soy germ alleviates gut barrier injury, hyperalgesia and faecal protease activity in a rat model of inflammatory bowel disease. PLoS One 2012;7(11):e49547.

pubmed

Moussa L, Bézirard V, Salvador-Cartier C, Bacquié V, Houdeau E, Theodorou V.  A new soy germ fermented ingredient displays estrogenic and protease inhibitor activities able to prevent irritable bowel syndrome-like symptoms in stressed female rats. Clin Nutr 2013;32(1):51-8.

pubmed

Annaházi A, Molnár T, Farkas K, Rosztóczy A, Izbéki F, Gecse K, Inczefi O, Nagy F, Földesi I, Szűcs M, Dabek MFerrier L, Theodorou V, Bueno L, Wittmann T, Róka R. Fecal MMP-9: A new noninvasive differential diagnostic and activity marker in ulcerative colitis. Inflamm Bowel Dis 2013;19(2):316-20.

pubmed

 

2012

Olier M, Marcq I, Salvador-Cartier C, Secher T, Dobrindt U, Boury M, Bacquié V, Pénary M, Gaultier E, Nougayrède JP, Fioramonti J, Oswald E. Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity.  Gut Microbes 2012;3(6):501-9. 

pubmed

Ait-Belgnaoui A, Durand H, Cartier C, Chaumaz G, Eutamene H, Ferrier L, Houdeau E, Fioramonti J, Bueno L, Theodorou V. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinology 2012;37(11):1885-95.

pubmed

Agostini S, Goubern M, Tondereau V, Salvador-Cartier C, Bezirard V, Lévèque M, Keränen H, Theodorou V, Bourdu-Naturel S, Goupil-Feuillerat N, Legrain-Raspaud S, Eutamene H. A marketed fermented dairy product containing Bifidobacterium lactis CNCM I-2494 suppresses gut hypersensitivity and colonic barrier disruption induced by acute stress in rats. Neurogastroenterol Motil 2012;24(4):376-e172

pubmed

Serino M, Luche E, Gres S, Baylac A, Bergé M, Cenac C, Waget A, Klopp P, Iacovoni J, Klopp C, Mariette J, Bouchez O, Lluch J, Ouarné F, Monsan P, Valet P, Roques C, Amar J, Bouloumié A, Theodorou V, Burcelin R. Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota. Gut 2012;61(4):543-53

pubmed

Annaházi A, Dabek M, Gecse K, Salvador-Cartier CPolizzi A, Rosztóczy A, Róka R, Theodorou V, Wittmann T, Bueno L, Eutamene H. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activated feed-back loop in visceral inflammatory pain. Neurogastroenterol Motil 2012;24(1):76-85, e13

pubmed

Vivinus-Nébot M, Dainese R, Anty R, Saint-Paul MC, Nano JL, Gonthier N, Marjoux S, Frin-Mathy G, Bernard G, Hébuterne X, Tran A, Theodorou V, Piche T. Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells. Am J Gastroenterol 2012;107(1):75-81

pubmed

2011

Bai J, Khaldi S, Gargala G, Baishanbo A, François A, Ballet JJ, Ducrotté P, Fioramonti J, Favennec L, Le Goff L. Effects of octreotide on jejunal hypersensitivity triggered by Cryptosporidium parvum intestinal infection in an immunocompetent suckling rat model. Neurogastroenterol Motil 2011;23(11):1043-50, e499

pubmed

Clermont O, Olier M, Hœde C, Diancourt L, Brisse S, Keroudean M, Glodt J, Picard B, Oswald E, Denamur E. Animal and human pathogenic Escherichia coli strains share common genetic backgrounds. Infect Genet Evol 2011;11(3):654-62. 

pubmed

Dabek MFerrier LAnnahazi ABézirard VPolizzi ACartier CLevêque M, Roka R, Wittmann T, Theodorou VBueno L. Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: role of cathepsin G and Protease-Activated Receptor 4. Inflamm Bowel Dis 2011;17(6):1409-1. 

pubmed

Olivier I, Theodorou V, Valet P, Castan-Laurell I, Guillou H, Bertrand-Michel J, Cartier C, Bézirard V, Ducroc R, Segain JP, Portier G, Kirzin S, Moreau J, Duffas JP, Ferrier LEutamène H. Is Crohn’s creeping fat an adipose tissue ? Inflamm Bowel Dis 2011;17(3):747-57.

Braniste V, Audebert M, Zalko D, Houdeau E. Bisphenol A in the Gut: Another Break in the Wall? In Multi-System Endocrine Disruption - Series: Research and Perspectives in Endocrine Interactions. Bourguignon J.-P., Jégou B., Kerdelhué B., Toppari J., Christen Y. (Eds.). Springer-Verlag Berlin Heidelberg 2011. pp127.

Clermont O, Olier M, Hœde C, Diancourt L, Brisse S, Keroudean M, Glodt J, Picard B, Oswald E, Denamur E. Animal and human pathogenic Escherichia coli strains share common genetic backgrounds. Infect Genet Evol 2011;11(3):654-62 [IF=3.223].
pubmed
Dabek M, Ferrier L, Annahazi A, Bézirard V, Polizzi A, Cartier C, Levêque M, Roka R, Wittmann T, Theodorou V, Bueno L. Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: role of cathepsin G and Protease-Activated Receptor 4. Inflamm Bowel Dis 2011;17(6):1409-14 [IF=4.643]. pubmed

Houdeau E. Pertubateurs endocriniens et contamination orale : l'intestin oublié. Médecine & Longévité 2011;3(2):85-93. logo_sciencedirect

Olivier I, Theodorou V, Valet P, Castan-Laurell I, Guillou H, Bertrand-Michel J, Cartier C, Bézirard V, Ducroc R, Segain JP, Portier G, Kirzin S, Moreau J, Duffas JP, Ferrier L, Eutamène H. Is Crohn’s creeping fat an adipose tissue ? Inflamm Bowel Dis 2011;17(3):747-57 [IF=4.643]. pubmed

2010

Agostini S, Eutamene H,Cartier C, Broccardo M, Improta G, Houdeau E, Petrella C, Ferrier L, Theodorou V, Bueno L. Evidence of Central and Peripheral Sensitization in a Rat Model of Narcotic Bowel Like-Syndrome. Gastroenterology 2010;139(2):553-63 [IF=12.899].
pubmed

Braniste V, Jouault A, Gaultier E, Polizzi A, Buisson-Brenac C, Leveque M, Martin PG, Theodorou V, Fioramonti J, Houdeau E. Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats. Proc Natl Acad Sci U S A 2010;107(1):448-53 [IF=9.432].
pubmed
Estienne M, Claustre J, Clain-Gardechaux G, Paquet A, Taché Y, Fioramonti J, Plaisancié P. Maternal deprivation alters epithelial secretory cell lineages in rat duodenum: role of CRF-related peptides. Gut 2010;59(6):744-51 [IF=9.357].
pubmed
Eutamene H, Bradesi S, Larauche M, Theodorou V,Beaufrand C, Ohning G, Fioramonti J, Cohen M, Bryant AP, Kurtz C, Currie MG, Mayer EA, Bueno L. Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain. Neurogastroenterol Mot 2010;22(3):312-e84 [IF=3.568].
pubmed

Ferrier L, Serradeil-Le Gal C, Schulte AM, Vasina V, Gaultier E, Schroedel S, Ursino MG, Chaumaz G, Pascal M, De Ponti F, Bueno L. Pro-inflammatory role of vasopressin through V1b receptors in hapten-induced experimental colitis in rodents : implication in IBD. Am J Physiol 2010; 299(6):G1298-307 [IF=3.258].
pubmed
Grimoud J, Durand H, Courtin C, Monsan P, Ouarné F, Theodorou V, Roques C. In vitro screening of probiotic lactic acid bacteria and prebiotic glucooligosaccharides to select effective synbiotics. Anaerobe 2010;16(5):493-500 [IF=1.633].
pubmed
Grimoud J, Durand H, de Souza S, Monsan P, Ouarné F, Theodorou V, Roques C. In vitro screening of probiotics and synbiotics according to anti-inflammatory and anti-proliferative effects. Int J Food Microbiol 2010;144(1):42-50 [IF=3.011].
pubmed

Petrella C, Agostini S, Alema' GS, Casolini P, Carpino F, Giuli C, Improta G, Linari G, Petrozza V, Broccardo M. Cannabinoid agonist WIN55,212 in vitro inhibits interleukin-6 (IL-6) and monocyte chemo-attractant protein-1 (MCP-1) release by rat pancreatic acini and in vivo induces dual effects on the course of acute pancreatitis. Neurogastroenterol Mot 2010;22(11):1248-56 [IF=3.568].
pubmed
Wittmann T, Paradowski L, Ducrotté P, Bueno L, Andro Delestrain MC. Clinical trial: the efficacy of alverine citrate/simeticone combination on abdominal pain/discomfort in irritable bowel syndrome--a randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther 2010;31(6):615-24 [IF=4.357].
pubmed