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Genotoxicity & Signaling Team

Team leader and contact:

Gladys MIREY
UMR 1331 TOXALIM INRA/INP/UPS
180, chemin de Tournefeuille, BP 93173
31027 TOULOUSE Cedex 3
France

Phone: +33 582 06 63 00
Fax: +33 561 28 52 44

Team members

photo_E8_2018

(see picture from left to right, 1st rank then 2nd rank)

  • Julie FINKEL, Master 'Biosanté' (2018)
  • Saleha HASHIM, Tech. (Faculty of Pharmacy)
  • Gladys MIREY, PhD, PI and team leader (INRA)
  • Anne FERNANDEZ-VIDAL, PhD, Ass. Prof. (Faculty of Pharmacy)
  • Aloïs CHEVALIER, Tech. Internship (2018 & 2019)
  • Julien VIGNARD, PhD, PI (INRA)
  • Thomas SAPIR, Microbiology Master (2018)
  • Aurélie BOBET, Master 'Biosanté' (2018)
  • Benoît PONS, PhD student (2016-2019)

Not on the picture:

  • Soraya TADRIST, Tech. INRA (arrived Oct. 2018)
  • Catherine BOUCHENOT, Tech. Faculty of Pharmacy (arrived Feb. 2019)
  • Aurélie PETTES, Assistant Engineer (arrived Feb. 2019)
  • William TREMBLAY, Master student (arrived Feb. 2019)
  • Florence MOMPART, Assistant Engineer INRA (arrived April 2019)

1) Staff

(alphabetical order)

Catherine BOUCHENOT, Technician (Faculty of Pharmacy)

Tel :
Fax : +33 561 28 52 44

  • Catherine was recruited in 2009 as Technician at the Faculty of Pharmacy of the University of Toulouse, within the Biochemistry department. She worked for 10 years at CRCT Inserm (team 3 - RhoGTPases in tumor progression), mainly on the subcellular localization of RhoGTPases thanks to the "split-GFP" complementation system. In February 2019, she joined the team and is now working on the genotoxic effects of the Cytolethal Distending Toxin (CDT) in colorectal carcinogenesis.​

Aloïs CHEVALIER

  • Aloïs studied at Puy-en-Velay and joined the team for his two internships as technician. He is working on biochemical activities of the Cytolethal Distending Toxin (CDT) and and is studying its cellular effects.

Anne FERNANDEZ-VIDAL (PhD), MCU

Tel : +33 582 06 63 44
Fax : +33 561 28 52 44

  • Anne received her Ph.D on Cancer from the University Paul Sabatier in Toulouse in 2008 (INSERM-U563 Eq B Payrastre). During these three years, she analyzed the impact of microenvironment on the proliferation of hematopoietic cells. She completed her post-doctoral in J-S Hoffmann’s team (CNRS - INSERM U1037) on the mechanisms of control of DNA replication whose the deregulation generates genetic instability. Anne joined our team in September 2015 as Ass. Prof. in Toxicology at the Faculty of Pharmacy of Toulouse. She currently focuses her activity towards the study of replicative stress and host adaptation following exposure to several xenobiotics such as bacterial toxin CDT.

Saleha HASHIM, Technician (Faculty of Pharmacy)

Tel : +33 582 06 63 63
Fax : +33 561 28 52 44

  • Saleha was recruited in 2008. She participates in the preparation of the Toxicology practical courses at the Faculty of Pharmacy, and within the team, she manages to maintain the solutions and materials needed for the experiments.

Gladys MIREY (PhD, HDR), MCU

Tel : +33 582 06 63 68
Fax : +33 561 28 52 44

  • Gladys received her Ph.D. in Molecular and Cell Biology in 2000 in Paris (Institut Curie) and completed a postdoctoral fellowship at Harvard University in the United States and at the University of Toulouse. Her work focuses on the study of signaling pathways and the regulation of the cell cycle. Lecturer in Cell Biology in Strasbourg, she joined the team of B. Salles in 2008 and directed its activity towards the development of biotracers to characterize and monitor the effects of genotoxic substances.

Florence MOMPART, INRA Ingeneer

Tel :
Fax : +33 561 28 52 44

Florence worked 8 years at INRA Tours to understand the mechanisms responsible for the virulence and carriage of salmonella in poultry farms. She studied in vivo and in vitro infections, and achieved kinetics of Salmonella contamination (molecular biology studies). Florence joined the Genphyse Unit in Auzeville in 2001 and focused on cell genetics approaches. She has contributed to the realization of the comparative map Man-Pig by high-throughput PCR, and also studied functional mapping and 3D architecture of the nucleus in order to understand the mechanisms of gene regulation (immunity genes and genes subjected to parental fingerprinting) in their chromatin environment, at the cell scale (by FISH3D and confocal microscopy). Florence joined the team in 2019 and is now working on the genotoxic effects of the Cytolethal Distending Toxin (CDT) in colorectal carcinogenesis.

Aurélie PETTES, Assistant engineer (2019-2021)

Tel : +33 582 06 64 19
Fax : +33 561 28 52 44

  • Aurélie obtained a Master's degree (Pharmacology Innovation) at Paul Sabatier University in Toulouse. During her training, she completed two 5-month internships (CRCT at JJ Fournier's lab, on lymphocytes of CLL patients to study treatment response, and I2MC at C.Galès's lab to study the response of GPCRs agonists). She is now working on the NP-scope project to study nanoparticles effects on oral epithelial cells.

Benoît PONS, PhD trainee (2016-2019)

Tel : +33 582 06 64 19
Fax : +33 561 28 52 44

  • Benoit studied engineering in biochemistry at the National Institute of Applied Sciences (INSA) in Toulouse. He joined the team in 2016. His PhD thesis research work addresses the genotoxic effects of Cytolethal Distending Toxin (CDT) bacterial toxin in colorectal carcinogenesis.

Soraya TADRIST, (Technician, INRA)

Tel :
Fax : +33 561 28 52 44

  • Soraya joined INRA in 2000 and has been a technician for 10 years. She joined the team in November 2018. Her activities are dedicated to molecular biology (PCR amplification, site-directed mutagenesis, cloning, sequence analysis).

William TREMBLAY,

Tel : +33 582 06 63 82
Fax : +33 561 28 52 44

  • William studied in Montpellier before completing his Master's degree in Integrative Biology and Toxicology in Toulouse. He joined the team to study the genotoxic effects of Cytolethal Distending Toxin (CDT) on colon organoids.

Julien VIGNARD, (PhD, INRA)

Tel : +33 582 06 63 64
Fax : +33 561 28 52 44

  • Julien received his Ph.D. in Cellular Biology at INRA Versailles, in 2007 before moving to Canada for a post-doctoral leave (J.Y. Masson, Quebec) mainly focused onDNA damage repair mechanisms by focusing more particularly on homologous recombination. Julien joined our team in September 2011 as a Research Fellowand currently focuses on the development of biomarkers of DNA damage in order to develop new tests of genotoxicity.

2) Former Trainees/team members

(by date)

Vanessa GRAILLOT, Post Doctorante (2015-2017)

  • Vanessa obtained her PhD in Toxicology (University of Toulouse) in 2012 at Toxalim. Her work focused on the quantitative assessment of dietary exposure to mixtures of pesticides and mechanisms of genotoxicity. She was recruited in 2015 to develop a real-time micronucleus assay as part of the Genotrace project.

Bernard SALLES , Dr in Pharmacy, HDR, PREX2 (2011-2017)

  • Bernard created and headed from 1991 to 2010 the team "Radiobiology and DNA repair" of the IPBS (UMR5089 CNRS / University) dedicated to the repair of DNA lesions and, more recently, DNA breaks. One of the objectives was to validate molecules that sensitize tumor cells to radiation treatment which induce breaks by inhibition of repair activity. The team was supported by various national and regional grants and by the canceropole GSO, the ARC (cancer research association) and La Ligue (League against Cancer labeled team). Bernard leads the new Institute TOXALIM dedicated to the study of food contaminants and their long-term effects on human and animal health.

Elisa BOUTET (MCU, Dr in Pharmacy, PhD, HDR : 2011-2017)

  • Elisa studied Pharmacy in Lyon (France) and obtained her PhD in pharmaceutical industry between 1999 and 2002. She completed her post-doctoral and her ATER in cancerology in Toulouse (INSERM, C Susini team). She is Senior Lecturer in Toxicology at the Faculty of Pharmacy of Toulouse since 2005. She focused her research in the field of toxicology, including occupational toxicology of pesticides. She has directed its activity towards the genotoxicity of these products by studying DNA damage in samples from a cohort of farmers. In addition to this research on pesticides, Elisa is involved in other collaborative projects to study the genotoxicity of various food contaminants, such as nanoparticles, and especially TiO2.

Marianne CHEVALIER, CDD Assitant Engineer (2014-2017)

  • Marianne obtained a BTS Bioanalyses and Controls at the Lycée Jean Mermoz in Montpellier. She was hired for the project "Pesticides exposure, Biomarkers and Genetic Polymorphisms" funded by ITMO Cancer-INCA (Coordination Elisa Boutet). For this project, she is working on samples from a cohort of farmers exposed to pesticides.

Sarah BETTINI, PhD student (2013-2016)

  • Sarah studied Cellular Biology & Immunology at Paul Sabatier University (Toulouse 3). She joined our team (and team 11) in 2013 for her PhD program. She's working on the genotoxicity of nanoparticles, especially TiO2 as food contaminant.

Elisabeth BEZINE, PhD student (2012-2015)

  • Elisabeth studied Cellular and Molecular Biology at the University Paul Sabatier in Toulouse. She joined our team in 2012 as part of its Master 2 Recherche. Her subject was the study of signaling pathways activated in response to damage caused by the bacterial toxin CDT.

Denis JULLIEN, Post-doc (2011-2013)

  • Denis received his Ph.D. from the University Paul Sabatier in Toulouse in 1998. During his postdoctoral fellowship at Edinburgh in the team of Y. Adachi, he was a pioneer in the study of protein 53BP1 foci in double-strand break. He subsequently joined the start-up ENDOCUBE in Toulouse with a translational research project in the field of inflammation. Back in 2007 to the academia, he became interested in controlling G2 / M transition in the team of B. Ducommun, in particular through the regulation of CDC25B phosphatase. Since 2011, he has worked to develop fluorescent sensors for detection of genotoxic stress.

Yoann FEDOR, PhD student (MESR) 2009-2012

  • Yoann joined the team in 2008 on the occasion of his Master 2, on the study of new features of the protein Ku - involved in the repair of double-strand breaks through the mechanism of the Non homologous end joining (NHEJ). He obtained a grant to initiate a doctoral work (2009-2012) and to develop biomarkers of double-strand DNA breaks.

Marie-Laure TRAVERS, Study Engineer (2010-2011)

  • Marie-Laure joined the team in 2010 to study the mechanisms leading to double-strand breaks in DNA after exposure of cells to toxin CDT. She specialized in flow cytometry but also developped biochemical and cellular approaches.