Welcome to the First Toxalim Keynote Meeting
Toxalim - Research Centre in Food Toxicology - organizes a one-day scientific symposium on the topic of sexual dimorphism in toxicology and health, which will focus on the double question of sex differences in biology, but also the impact of gender on scientific contributions.
- Sexual dimorphism groups together the phenotypic (physiological and behavioral) differences between individuals of the opposite sex within the same species.It is an important issue in pre-clinical and clinical research (the inclusion of women in clinical research has become mandatory since 1993 for the NIH (NIH revitalization act)).
- However, in pre-clinical research and more specifically in toxicology, this revolution has not taken place either in the development of experimental protocols, or in data analysis of research on animal or cellular models. This over-representation of male model data obscures potentially important sex differences to guide clinical (animal or human) research or risk assessment. And this can be deleterious: women are more prone to the side effects of drugs than men. And for environmental toxins?
- In animals, different toxic effects between males and females have been described. In some cases, the link with specific hepatic detoxification mechanisms has been established.
The objectives of this symposium are to :
- deepen scientists' knowledge of sexual dimorphism
- establish an inventory of the molecular mechanisms that govern sexual dimorphism in models commonly used in toxicological research
- question the role of gender in developing research questions and the results obtained
- stimulate discussions about the relevance of including both sexes in studies (animal and cellular models)
Oral Flash presentations addressing these issues are welcome!
The conference is free but the participants must ensure their transport and accommodation in Toulouse.
Beware : the number of participants is limited to 150.
Online registration deadline: 19 March 2018
Deadline for submission of abstracts online: March 11, 2018
More Info & Registration :