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2024

• Berlivet J, Payrastre L, Rebouillat P, Fougerat A, Touvier M, Hercberg S, Lairon D, Pointereau P, Guillou H, Vidal R, Baudry J, Kesse-Guyot E. Association between dietary pesticide exposure profiles and body weight change in French adults: Results from the NutriNet-Santé cohort. Environ Int. 2024 Feb;184:108485. doi: 10.1016/j.envint.2024.108485.
• Ursic-Bedoya J, Desandré G, Chavey C, Marie P, Polizzi A, Rivière B, Guillou H, Assenat E, Hibner U, Gregoire D. FGF19 and its analog Aldafermin cooperate with MYC to induce aggressive hepatocarcinogenesis. EMBO Mol Med. 2024 Feb;16(2):238-250. doi: 10.1038/s44321-023-00021-x.
• Sparfel L, Ratodiarivony S, Boutet-Robinet E, Ellero-Simatos S, Jolivet-Gougeon A. Akkermansia muciniphila and Alcohol-Related Liver Diseases. A Systematic Review. Mol Nutr Food Res. 2024 Jan;68(2):e2300510. doi: 10.1002/mnfr.202300510.
• Cresto N, Courret M, Génin A, Martin CMP, Bourret J, Sakkaki S, de Bock F, Janvier A, Polizzi A, Payrastre L, Ellero-Simatos S, Audinat E, Perroy J, Marchi N. Continuous low-level dietary exposure to glyphosate elicits dose and sex-dependent synaptic and microglial adaptations in the rodent brain. Environ Pollut. 2024 Mar 15;345:123477. doi: 10.1016/j.envpol.2024.123477.
• Baudiffier D, Audouze K, Armant O, Frelon S, Charles S, Beaudouin R, Cosio C, Payrastre L, Siaussat D, Burgeot T, Mauffret A, Degli Esposti D, Mougin C, Delaunay D, Coumoul X. Editorial trend: adverse outcome pathway (AOP) and computational strategy - towards new perspectives in ecotoxicology. Environ Sci Pollut Res Int. 2024 Jan;31(5):6587-6596. doi: 10.1007/s11356-023-30647-w.
• Evenden P, Vandoolaeghe Q, Lecluse Y, Gac AC, Delépée R, Weiswald LB, Boutet-Robinet E, Boulanger M, Bonassi S, Lebailly P, Meryet-Figuière M. Agricultural exposures and DNA damage in PBMC of female farmers measured using the alkaline comet assay. Int Arch Occup Environ Health. 2024 Mar 2. doi: 10.1007/s00420-024-02049-z.
• Rives C, Martin CMP, Evariste L, Polizzi A, Huillet M, Lasserre F, Alquier-Bacquie V, Perrier P, Gomez J, Lippi Y, Naylies C, Levade T, Sabourdy F, Remignon H, Fafournoux P, Chassaing B, Loiseau N, Guillou H, Ellero-Simatos S, Gamet-Payrastre L, Fougerat A. Dietary Amino Acid Source Elicits Sex-Specific Metabolic Response to Diet-Induced NAFLD in Mice. Mol Nutr Food Res. 2024 Jan;68(1):e2300491. doi: 10.1002/mnfr.202300491. 

2023

• Huillet M, Lasserre F, Gratacap MP, Engelmann B, Bruse J, Polizzi A, Fougeray T, Martin CMP, Rives C, Fougerat A, Naylies C, Lippi Y, Garcia G, Rousseau-Bacquie E, Canlet C, Debrauwer L, Rolle-Kampczyk U, von Bergen M, Payrastre B, Boutet-Robinet E, Gamet-Payrastre L, Guillou H, Loiseau N, Ellero-Simatos S. Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism. JHEP Rep. 2023 Oct 13;6(1):100930. doi: 10.1016/j.jhepr.2023.100930.
• Piccinin E, Arconzo M, Matrella ML, Cariello M, Polizzi A, Lippi Y, Bertrand-Michel J, Guillou H, Loiseau N, Villani G, Moschetta A. Intestinal Pgc1α ablation protects from liver steatosis and fibrosis. JHEP Rep. 2023 Jul 19;5(11):100853. doi: 10.1016/j.jhepr.2023.100853.
• Sakkaki S, Cresto N, Chancel R, Jaulmes M, Zub E, Blaquière M, Sicard P, Maurice T, Ellero-Simatos S, Gamet-Payrastre L, Marchi N, Perroy J. Dual-Hit: Glyphosate exposure at NOAEL level negatively impacts birth and glia-behavioural measures in heterozygous shank3 mutants. Environ Int. 2023 Oct;180:108201. doi: 10.1016/j.envint.2023.108201. 
• Schoeler M, Ellero-Simatos S, Birkner T, Mayneris-Perxachs J, Olsson L, Brolin H, Loeber U, Kraft JD, Polizzi A, Martí-Navas M, Puig J, Moschetta A, Montagner A, Gourdy P, Heymes C, Guillou H, Tremaroli V, Fernández-Real JM, Forslund SK, Burcelin R, Caesar R. The interplay between dietary fatty acids and gut microbiota influences host metabolism and hepatic steatosis. Nat Commun. 2023 Sep 1;14(1):5329. doi: 10.1038/s41467-023-41074-3.
• Allaire M, Al Sayegh R, Mabire M, Hammoutene A, Siebert M, Caër C, Cadoux M, Wan J, Habib A, Le Gall M, de la Grange P, Guillou H, Postic C, Paradis V, Lotersztajn S, Gilgenkrantz H. Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration. JHEP Rep. 2023 May 16;5(8):100794. doi: 10.1016/j.jhepr.2023.100794.
• Dopavogui L, Régnier M, Polizzi A, Ponchon Q, Smati S, Klement W, Lasserre F, Lukowicz C, Lippi Y, Fougerat A, Bertrand-Michel J, Naylies C, Canlet C, Debrauwer L, Rousseau-Bacquié E, Gamet-Payrastre L, Dauriat C, Casas J, Croubels S, De Baere S, Burger HM, Chassaing B, Ellero-Simatos S, Guillou H, Oswald IP, Loiseau N. Obesity promotes fumonisin B1 hepatotoxicity. Sci Total Environ. 2023 Sep 15;891:164436. doi: 10.1016/j.scitotenv.2023.164436. 
• Sabatier M, Birsen R, Lauture L, Mouche S, Angelino P, Dehairs J, Goupille L, Boussaid I, Heiblig M, Boet E, Sahal A, Saland E, Santos JC, Armengol M, Fernández-Serrano M, Farge T, Cognet G, Simonetta F, Pignon C, Graffeuil A, Mazzotti C, Avet-Loiseau H, Delos O, Bertrand-Michel J, Chedru A, Dembitz V, Gallipoli P, Anstee NS, Loo S, Wei AH, Carroll M, Goubard A, Castellano R, Collette Y, Vergez F, Mansat-De Mas V, Bertoli S, Tavitian S, Picard M, Récher C, Bourges-Abella N, Granat F, Kosmider O, Sujobert P, Colsch B, Joffre C, Stuani L, Swinnen JV, Guillou H, Roué G, Hakim N, Dejean AS, Tsantoulis P, Larrue C, Bouscary D, Tamburini J, Sarry JE. C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia. Cancer Discov. 2023 Jul 7;13(7):1720-1747. doi: 10.1158/2159-8290.
• Evariste L, Lamas B, Ellero-Simatos S, Khoury L, Cartier C, Gaultier E, Chassaing B, Feltin N, Devoille L, Favre G, Audebert M, Houdeau E. A 90-day oral exposure to food-grade gold at relevant human doses impacts the gut microbiota and the local immune system in a sex-dependent manner in mice. Part Fibre Toxicol. 2023 Jul 13;20(1):27. doi: 10.1186/s12989-023-00539-5.
• Vignard J, Pettes-Duler A, Gaultier E, Cartier C, Weingarten L, Biesemeier A, Taubitz T, Pinton P, Bebeacua C, Devoille L, Dupuy J, Boutet-Robinet E, Feltin N, Oswald IP, Pierre FH, Lamas B, Mirey G, Houdeau E. Food-grade titanium dioxide translocates across the buccal mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium. Nanotoxicology. 2023 Jun;17(4):289-309. doi: 10.1080/17435390.2023.2210664. 
• Collins A., Møller P., Gajski G., Vodenková S., Abdulwahed A., Anderson D., Bankoglu E.E., Bonassi S., Boutet-Robinet E., Brunborg G, Chao C, Cooke MS, Costa C, Costa S, Dhawan A, de Lapuente J, Bo' CD, Dubus J, Dusinska M, Duthie SJ, Yamani NE, Engelward B, Gaivão I, Giovannelli L, Godschalk R, Guilherme S, Gutzkow KB, Habas K, Hernández A, Herrero O, Isidori M, Jha AN, Knasmüller S, Kooter IM, Koppen G, Kruszewski M, Ladeira C, Laffon B, Larramendy M, Hégarat LL, Lewies A, Lewinska A, Liwszyc GE, de Cerain AL, Manjanatha M, Marcos R, Milić M, de Andrade VM, Moretti M, Muruzabal D, Novak M, Oliveira R, Olsen AK, Owiti N, Pacheco M, Pandey AK, Pfuhler S, Pourrut B, Reisinger K, Rojas E, Rundén-Pran E, Sanz-Serrano J, Shaposhnikov S, Sipinen V, Smeets K, Stopper H, Teixeira JP, Valdiglesias V, Valverde M, van Acker F, van Schooten FJ, Vasquez M, Wentzel JF, Wnuk M, Wouters A, Žegura B, Zikmund T, Langie SAS, Azqueta A. Measuring DNA modifications with the comet assay: a compendium of protocols. Nature Protocols. 2023 Jan 27. doi: 10.1038
• Remignon H, Burgues P. Evolution of oxidative stress markers in livers of ducks during force-feeding. Sci. Rep.2023; 13: 1046. doi:10.1038

2022

• Fougerat A, Schoiswohl G, Polizzi A, Régnier M, Wagner C, Smati S, Fougeray T, Lippi Y, Lasserre F, Raho I, Melin V, Tramunt B, Métivier R, Sommer C, Benhamed F, Alkhoury C, Greulich F, Jouffe C, Emile A, Schupp M, Gourdy P, Dubot P, Levade T, Meynard D, Ellero-Simatos S, Gamet-Payrastre L, Panasyuk G, Uhlenhaut H, Amri EZ, Cruciani-Guglielmacci C, Postic C, Wahli W, Loiseau N, Montagner A, Langin D, Lass A, Guillou H. ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity. Cell Rep. 2022 Jun 7;39(10):110910. doi: 10.1016/j.celrep.2022.110910.
• Ducheix S, Piccinin E, Peres C, Garcia-Irigoyen O, Bertrand-Michel J, Fouache A, Cariello M, Lobaccaro JM, Guillou H, Sabbà C, Ntambi JM, Moschetta A. Reduction in gut-derived MUFAs via intestinal stearoyl-CoA desaturase 1 deletion drives susceptibility to NAFLD and hepatocarcinoma. Hepatol Commun. 2022 Oct;6(10):2937-2949. doi: 10.1002/hep4.2053.
• Dopavogui L, Cadoret F, Loison G, El Fouikar S, Frenois FX, Giton F, Ellero-Simatos S, Lasserre F, Polizzi A, Rives C, Loiseau N, Léandri RD, Gatimel N, Gamet-Payrastre L. Pre- and Postnatal Dietary Exposure to a Pesticide Cocktail Disrupts Ovarian Functions in 8-Week-Old Female Mice. Int J Mol Sci. 2022 Jul 7;23(14):7525. doi: 10.3390/ijms23147525.
• de Sire A, de Sire R, Curci C, Castiglione F, Wahli W. Role of Dietary Supplements and Probiotics in Modulating Microbiota and Bone Health: The Gut-Bone Axis. Cells. 2022, 11(4):743. doi: 10.3390/cells11040743.
• Rives C, Fougerat A, Gamet-Payrastre L. Développement des désordres métaboliques: influence de l’exposition aux pesticides. Diabète et Obésité. 2022, 17(151):1-7.
• Bodin N, Amiel A, Fouché E, Sardenne F, Chassot E, Debrauwer L, Guillou H, Tremblay-Franco M, Canlet C. NMR-based metabolic profiling and discrimination of wild tropical tunas by species, size category, geographic origin, and on-board storage condition. Food Chem. 2022, 371:131094. doi: 10.1016/j.foodchem.2021.131094.
• Baptissart M, Bradish CM, Jones BS, Walsh E, Tehrani J, Marrero-Colon V, Mehta S, Jima DD, Oh SH, Diehl AM, Fougeray T, Guillou H, Cowley M. Zac1 and the Imprinted Gene Network program juvenile NAFLD in response to maternal metabolic syndrome. Hepatology. 2022, doi: 10.1002/hep.32363.
• Personnaz J, Piccolo E, Dortignac A, Iacovoni JS, Mariette J, Rocher V, Polizzi A, Batut A, Deleruyelle S, Bourdens L, Delos O, Combes-Soia L, Paccoud R, Moreau E, Martins F, Clouaire T, Benhamed F, Montagner A, Wahli W, Schwabe RF, Yart A, Castan-Laurell I, Bertrand-Michel J, Burlet-Schiltz O, Postic C, Denechaud PD, Moro C, Legube G, Lee CH, Guillou H, Valet P, Dray C, Pradère JP. Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor. Sci Adv. 2022, 8(12):eabg9055.
• Fougeray T, Polizzi A, Régnier M, Fougerat A, Ellero-Simatos S, Lippi Y, Smati S, Lasserre F, Tramunt B, Huillet M, Dopavogui L, Salvi J, Nédélec E, Gigot V, Smith L, Naylies C, Sommer C, Haas JT, Wahli W, Duez H, Gourdy P, Gamet-Payrastre L, Benani A, Burnol AF, Loiseau N, Postic C, Montagner A, Guillou H. The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression. Cell Rep. 2022, 39(2):110674.doi: 10.1016/j.celrep.2022.110674.
• Vázquez-Carrera M, Wahli W. PPARs as Key Mediators in the Regulation of Metabolism and Inflammation.  Int J Mol Sci. 2022, 23(9):5025.doi: 10.3390/ijms23095025.
• Rebouillat P, Vidal R, Cravedi JP, Taupier-Letage B, Debrauwer L, Gamet-Payrastre L, Guillou H, Touvier M, Fezeu LK, Hercberg S, Lairon D, Baudry J, Kesse-Guyot E. Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Santé cohort. Environ Health. 2022, 21(1):57.doi: 10.1186/s12940-022-00862-y.
• Lo B, Marty-Gasset N, Manse H, Canlet C, Domitile R, Remignon H. Slightly different metabolomic profiles are associated with high or low weight duck foie gras. PLoS One. 2022, 17(6):e0255707.doi: 10.1371/journal.pone.0255707.
• Fougerat A, Schoiswohl G, Polizzi A, Régnier M, Wagner C, Smati S, Fougeray T, Lippi Y, Lasserre F, Raho I, Melin V, Tramunt B, Métivier R, Sommer C, Benhamed F, Alkhoury C, Greulich F, Jouffe C, Emile A, Schupp M, Gourdy P, Dubot P, Levade T, Meynard D, Ellero-Simatos S, Gamet-Payrastre L, Panasyuk G, Uhlenhaut H, Amri EZ, Cruciani-Guglielmacci C, Postic C, Wahli W, Loiseau N, Montagner A, Langin D, Lass A, Guillou H. ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity. Cell Rep. 2022, 39(10):110910. doi: 10.1016/j.celrep.2022.110910.
• Dopavogui L, Polizzi A, Fougerat A, Gourbeyre P, Terciolo C, Klement W, Pinton P, Laffite J, Cossalter AM, Bailly JD, Puel O, Lippi Y, Naylies C, Guillou H, Oswald IP, Loiseau N. Tissular Genomic Responses to Oral FB1 Exposure in Pigs.  Toxins. 2022, 14, 83. doi: 10.3390/toxins14020083.
• Ben Fradj S, Nedelec E, Salvi J, Fouesnard M, Huillet M, Pallot G, Cansell C, Sanchez C, Philippe C, Gigot V, Lemoine A, Trompier D, Henry T, Petrilli V, Py B, Guillou H, Loiseau N, Ellero-Simatos S, Nahon JL, Rovère C, Grober J, Boudry G, Douard V, Benani A. Evidence for constitutive microbiota-dependent short-term control of food intake in mice: Is there a link with inflammation, oxidative stress, endotoxemia, and Glp-1?  Antioxid Redox Signal. 2022 Feb 15. doi: 10.1089/ars.2021.0095.
• Bodin N, Amiel A, Fouché E, Sardenne F, Chassot E, Debrauwer L, Guillou H, Tremblay-Franco M, Canlet C. NMR-based metabolic profiling and discrimination of wild tropical tunas by species, size category, geographic origin, and on-board storage condition. Food Chem. 2022 Mar 1;371:131094. doi: 10.1016/j.foodchem.2021.131094.

2021

• Kwan YP, Teo MHY, Lim JCW, Tan MS, Rosellinny G, Wahli W, Wang X. LRG1 Promotes Metastatic Dissemination of Melanoma through Regulating EGFR/STAT3 Signalling. Cancers (Basel). 2021, 13(13):3279. doi: 10.3390/cancers13133279.
• Demina EP, Smutova V, Pan X, Fougerat A, Guo T, Zou C, Chakraberty R, Snarr BD, Shiao TC, Roy R, Orekhov AN, Miyagi T, Laffargue M, Sheppard DC, Cairo CW, Pshezhetsky AV. Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low-Density Lipoproteins and Increasing Their Uptake by Macrophages. J Am Heart Assoc. 2021 Feb 16;10(4):e018756. doi: 10.1161/JAHA.120.018756.
• Belot A, Gourbeyre O, Palin A, Rubio A, Largounez A, Besson-Fournier C, Latour C, Lorgouilloux M, Gallitz I, Montagner A, Polizzi A, Régnier M, Smati S, Zhang AS, Diaz-Munoz MD, Steinbicker AU, Guillou H, Roth MP, Coppin H, Meynard D. Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR. Haematologica. 2021 Apr 1;106(4):1202-1206. doi: 10.3324/haematol.2019.237321.
• Cheng HS, Yip YS, Lim EKY, Wahli W, Tan NS. PPARs and Tumor Microenvironment: The Emerging Roles of the Metabolic Master Regulators in Tumor Stromal-Epithelial Crosstalk and Carcinogenesis. Cancers (Basel). 2021, 13(9):2153. doi: 10.3390/cancers13092153.
• Aguilar-Recarte D, Palomer X, Wahli W, Vázquez-Carrera M. The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance. Int J Mol Sci. 2021, 22(16):8555. doi: 10.3390/ijms22168555.
• Parlati L, Régnier M, Guillou H, Postic C. New targets for NAFLD. JHEP Rep. 2021, 3(6):100346. doi: 10.1016/j.jhepr.2021.100346.
• Aguilar-Recarte D, Barroso E, Gumà A, Pizarro-Delgado J, Peña L, Ruart M, Palomer X, Wahli W, Vázquez-Carrera M. GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK. Cell Rep. 2021, 10;36(6):109501. doi: 10.1016/j.celrep.2021.109501.
• Tramunt B, Montagner A, Tan NS, Gourdy P, Rémignon H, Wahli W. Roles of Estrogens in the Healthy and Diseased Oviparous Vertebrate Liver. Metabolites. 2021 Jul 30;11(8):502. doi: 10.3390/metabo11080502.
• Hinds TD Jr, Kipp ZA, Xu M, Yiannikouris FB, Morris AJ, Stec DF, Wahli W, Stec DE. Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue.  Cells. 2021 Dec 21;11(1):4. doi: 10.3390/cells11010004.
• Smati S, Polizzi A, Fougerat A, Ellero-Simatos S, Blum Y, Lippi Y, Régnier M, Laroyenne A, Huillet M, Arif M, Zhang C, Lasserre F, Marrot A, Al Saati T, Wan J, Sommer C, Naylies C, Batut A, Lukowicz C, Fougeray T, Tramunt B, Dubot P, Smith L, Bertrand-Michel J, Hennuyer N, Pradere JP, Staels B, Burcelin R, Lenfant F, Arnal JF, Levade T, Gamet-Payrastre L, Lagarrigue S, Loiseau N, Lotersztajn S, Postic C, Wahli W, Bureau C, Guillaume M, Mardinoglu A, Montagner A, Gourdy P, Guillou H. Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.  Gut. 2021 Apr 26:gutjnl-2020-323323. doi: 10.1136/gutjnl-2020-323323.
• Barretto SA, Lasserre F, Huillet M, Régnier M, Polizzi A, Lippi Y, Fougerat A, Person E, Bruel S, Bétoulières C, Naylies C, Lukowicz C, Smati S, Guzylack L, Olier M, Théodorou V, Mselli-Lakhal L, Zalko D, Wahli W, Loiseau N, Gamet-Payrastre L, Guillou H, Ellero-Simatos S. The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice.  Microbiome. 2021 9(1):93. doi: 10.1186/s40168-021-01050-9.
• Noblet B, Benhamed F, O-Sullivan I, Zhang W, Filhoulaud G, Montagner A, Polizzi A, Marmier S, Burnol AF, Guilmeau S, Issad T, Guillou H, Bernard C, Unterman T, Postic C. Dual regulation of TxNIP by ChREBP and FoxO1 in liver.  iScience. 2021 Feb 20;24(3):102218. doi: 10.1016/j.isci.2021.102218.
• Rebouillat P, Vidal R, Cravedi JP, Taupier-Letage B, Debrauwer L, Gamet-Payrastre L, Touvier M, Hercberg S, Lairon D, Baudry J, Kesse-Guyot E. Estimated dietary pesticide exposure from plant-based foods using NMF-derived profiles in a large sample of French adults.  Eur J Nutr. 2021 60(3):1475-1488. doi: 10.1007/s00394-020-02344-8.
• Rebouillat P, Vidal R, Cravedi JP, Taupier-Letage B, Debrauwer L, Gamet-Payrastre L, Touvier M, Deschasaux-Tanguy M, Latino-Martel P, Hercberg S, Lairon D, Baudry J, Kesse-Guyot E. Prospective association between dietary pesticide exposure profiles and postmenopausal breast-cancer risk in the NutriNet-Santé cohort.  Int J Epidemiol. 2021 Mar 15:dyab015. doi: 10.1093/ije/dyab015.
• Forner-Piquer I, Klement W, Gangarossa G, Zub E, de Bock F, Blaquiere M, Maurice T, Audinat E, Faucherre A, Lasserre F, Ellero-Simatos S, Gamet-Payrastre L, Jopling C, Marchi N. Varying modalities of perinatal exposure to a pesticide cocktail elicit neurological adaptations in mice and zebrafish. Environ Pollut. 2021 278:116755. doi: 10.1016/j.envpol.2021.116755.
• Forner-Piquer I, Faucherre A, Byram J, Blaquiere M, de Bock F, Gamet-Payrastre L, Ellero-Simatos S, Audinat E, Jopling C, Marchi N. Differential impact of dose-range glyphosate on locomotor behavior, neuronal activity, glio-cerebrovascular structures, and transcript regulations in zebrafish larvae. Chemosphere. 2021 267:128986. doi: 10.1016/j.chemosphere.2020.128986.
• Rousseau AS, Murdaca J, Le Menn G, Sibille B, Wahli W, Le Garf S, Chinetti G, Neels JG, Mothe-Satney I. Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity. Front Physiol. 2021 12:587753. doi: 10.3389/fphys.2021.587753.

2020

• Smati S, Régnier M, Fougeray T, Polizzi A, Fougerat A, Lasserre F, Lukowicz C, Tramunt B, Guillaume M, Burnol AF, Postic C, Wahli W, Montagner A, Gourdy P, Guillou H. Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-alpha and insulin-dependent signalling in hepatocytes. Diabetes Metab. 2020 46(2):129-136. doi: 10.1016/j.diabet.2019.05.005.
• Fougerat A, Montagner A, Loiseau N, Guillou H, Wahli W. Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease. Cells. 2020 9(7):1638. doi: 10.3390/cells9071638.
• Rives C, Fougerat A, Ellero-Simatos S, Loiseau N, Guillou H, Gamet-Payrastre L, Wahli W. Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants. Biomolecules. 2020 10(12):1702. doi: 10.3390/biom10121702. 267:128986.
• Smith L, Klément W, Dopavogui L, de Bock F, Lasserre F, Barretto S, Lukowicz C, Fougerat A, Polizzi A, Schaal B, Patris B, Denis C, Feuillet G, Canlet C, Jamin EL, Debrauwer L, Mselli-Lakhal L, Loiseau N, Guillou H, Marchi N, Ellero-Simatos S, Gamet-Payrastre L. Perinatal exposure to a dietary pesticide cocktail does not increase susceptibility to high-fat diet-induced metabolic perturbations at adulthood but modifies urinary and fecal metabolic fingerprints in C57Bl6/J mice. Environ Int. 2020 144:106010. doi: 10.1016/j.envint.2020.106010.
• Régnier M, Polizzi A, Smati S, Lukowicz C, Fougerat A, Lippi Y, Fouché E, Lasserre F, Naylies C, Bétoulières C, Barquissau V, Mouisel E, Bertrand-Michel J, Batut A, Al Saati T, Canlet C, Tremblay-Franco M, Ellero-Simatos S, Langin D, Postic C, Wahli W, Loiseau N, Guillou H, Montagner A. Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity. Sci Rep. 2020 10, 6489. doi: 10.1038/s41598-020-63579-32020.
• Lukowicz C, Ellero-Simatos S, Régnier M, Oliviero F, Lasserre F, Polizzi A, Montagner A, Smati S, Boudou F, Lenfant F, Guzylack-Pirou L, Menard S, Barretto S, Fougerat A, Lippi Y, Naylies C, Bertrand-Michel J, Belgnaoui AA, Theodorou V, Marchi N, Gourdy P, Gamet-Payrastre L, Loiseau N, Guillou H, Mselli-Lakhal L. Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor. Sci Rep. 2020 10(1):4256. doi: 10.1038/s41598-020-61226-5.
• Combedazou A, Gayral S, Colombié N, Fougerat A, Laffargue M, Ramel D. Small GTPases orchestrate cell-cell communication during collective cell movement. Small GTPases. 2020 11(2):103-112. doi: 10.1080/21541248.2017.1366965.
• Kesse-Guyot E, Rebouillat P, Payrastre L, Allès B, Fezeu LK, Druesne-Pecollo N, Srour B, Bao W, Touvier M, Galan P, Hercberg S, Lairon D, Baudry J. Prospective association between organic food consumption and the risk of type 2 diabetes: findings from the NutriNet-Santé cohort study. Int J Behav Nutr Phys Act. 2020 17(1):136. doi: 10.1186/s12966-020-01038-y.
• Pons BJ, Loiseau N, Hashim S, Tadrist S, Mirey G, Vignard J. Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B. Toxins (Basel). 2020 12(9):530. doi: 10.3390/toxins12090530.
• Smith L, Villaret-Cazadamont J, Claus SP, Canlet C, Guillou H, Cabaton NJ, Ellero-Simatos S. Important Considerations for Sample Collection in Metabolomics Studies with a Special Focus on Applications to Liver Functions. Metabolites. 2020 10(3). pii: E104. doi: 10.3390/metabo10030104.
• Inczefi O, Bacquié V, Olier-Pierre M, Rincel M, Ringot-Destrez B, Ellero-Simatos S, Eutamène H, Bétoulières C, Thomas J, Laine J, Gros L, Lévêque M, Leonard R, Harkat C, Robbe-Masselot C, Roka R, Mercier-Bonin M, Theodorou V, Darnaudéry M, Turner JR, Ferrier L. Targeted Intestinal Tight Junction Hyperpermeability Alters the Microbiome, Behavior, and Visceromotor Responses. Cell Mol Gastroenterol Hepatol. 2020 pii: S2352-345X(20)30035-7. doi: 10.1016/j.jcmgh.2020.02.008.
• Klement W, Oliviero F, Gangarossa G, Zub E, De Bock F, Forner-Piquer I, Blaquiere M, Lasserre F, Pascussi JM, Maurice T, Audinat E, Ellero-Simatos S, Gamet-Payrastre L, Mselli-Lakhal L, Marchi N. Life-long Dietary Pesticide Cocktail Induces Astrogliosis Along with Behavioral Adaptations and Activates p450 Metabolic Pathways. Neuroscience 2020 446:225-237. doi: 10.1016/j.neuroscience.2020.07.039.
• Martin PGP, Dupouy V, Leghait J, Pineau T, Polizzi A, Lasserre F, Roques BB, Viguié C. Transcriptomic modifications of the thyroid gland upon exposure to phytosanitary-grade fipronil: Evidence for the activation of compensatory pathways. Toxicol Appl Pharmacol. 2020 389:114873. doi: 10.1016/j.taap.2019.114873.

2019

• Régnier M, Polizzi A, Lukowicz C, Smati S, Lasserre F, Lippi Y, Naylies C, Laffitte J, Bétoulières C, Montagner A, Ducheix S, Gourbeyre P, Ellero-Simatos S, Menard S, Bertrand-Michel J, Al Saati T, Lobaccaro JM, Burger HM, Gelderblom WC, Guillou H, Oswald IP, Loiseau N. The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity. Arch Toxicol. 2019 93(2): 505-517. doi.org/10.1007/s00204-018-2345-2.
• Lukowicz C, Ellero-Simatos S, Régnier M, Oliviero F, Lasserre F, Polizzi A, Montagner A, Smati S, Boudou F, Lenfant F, Guzylack-Pirou L, Menard S, Barretto S, Fougerat A, Lippi Y, Naylies C, Bertrand-Michel J, Belgnaoui AA, Theodorou V, Marchi N, Gourdy P, Gamet-Payrastre L, Loiseau N, Guillou H, Mselli-Lakhal L. Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor. Sci Rep. 2019 9(1):20169. doi: 10.1038/s41598-019-56570-0.
• Barretto SA, Lasserre F, Fougerat A, Smith L, Fougeray T, Lukowicz C, Polizzi A, Smati S, Régnier M, Naylies C, Bétoulières C, Lippi Y, Guillou H, Loiseau N, Gamet-Payrastre L, Mselli-Lakhal L, Ellero-Simatos S. Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice. Int J Mol Sci. 2019 Aug 1;20(15). pii: E3767. doi: 10.3390/ijms20153767.
• Amiel A, Tremblay-Franco M, Gautier R, Ducheix S, Montagner A, Polizzi A, Debrauwer L, Guillou H, Bertrand-Michel J, Canlet C. Proton NMR Enables the Absolute Quantification of Aqueous Metabolites and Lipid Classes in Unique Mouse Liver Samples. Metabolites. 2019 10(1). pii: E9. doi: 10.3390/metabo10010009.
• Terciolo C, Bracarense AP, Souto PCMC, Cossalter AM, Dopavogui L, Loiseau N, Oliveira CAF, Pinton P, Oswald IP. Fumonisins at Doses below EU Regulatory Limits Induce Histological Alterations in Piglets. Toxins (Basel). 2019 11(9). pii: E548. doi: 10.3390/toxins11090548.
• Buis A, Bellemin S, Goudeau J, Monnier L, Loiseau N, Guillou H, Aguilaniu H. Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans. Cell Rep. 2019 28(4):1041-1049.e4. doi: 10.1016/j.celrep.2019.06.064.
• Guillaume M, Riant E, Fabre A, Raymond-Letron I, Buscato M, Davezac M, Tramunt B, Montagner A, Smati S, Zahredidine R, Paliernes G, Valera MC, Guillou H, Lenfant F, Unsicker K, Metivier R, Fontaine C, Arnal JF, Gourdy P. Selective liver Estrogen Receptor α modulation prevents steatosis, diabetes and obesity through the anorectic Gdf15 hepatokine in mice. Hepatol Commun. 2019 3(7):908-924. doi: 10.1002/hep4.1363.
• Habib A, Chokr D, Wan J, Hegde P, Mabire M, Siebert M, Ribeiro-Parenti L, Le Gall M, Lettéron P, Pilard N, Mansouri A, Brouillet A, Tardelli M, Weiss E, Le Faouder P, Guillou H, Cravatt BF, Moreau R, Trauner M, Lotersztajn S. Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver. Gut. 2019 68(3):522-532. pii: gutjnl-2018-316137. doi: 10.1136/gutjnl-2018-316137.
• Iershov A, Nemazanyy I, Alkhoury C, Girard M, Barth E, Cagnard N, Montagner A, Chretien D, Rugarli EI, Guillou H, Pende M, Panasyuk G. The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα. Nat Commun. 2019 10(1):1566. doi: 10.1038/s41467-019-09598-9.
• Ilchmann-Diounou H, Olier M, Lencina C, Riba A, Barretto S, Nankap M, Sommer C, Guillou H, Ellero-Simatos S, Guzylack-Piriou L, Théodorou V, Ménard S. Early life stress induces type 2 diabetes-like features in ageing mice. Brain Behavior and Immunity. 2019 80:452-463. doi: 10.1016/j.bbi.2019.04.025.
• Martin OCB, Olier M, Ellero-simatos S, Naud N, Dupuy J, Huc L, Taché S, Graillot V, Levêque M, Bézirard V, Héliès C, Blas-Y-Estrada F, Tondereau V, Lippi Y, Naylies C, Peyriga L, Canlet C, Davilla AM, Blachier F, Ferrier L, Boutet-Robinet E, Gueraud F, Théodorou V, Pierre FHF. Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation. Microbiome. 2019 7(1):72. doi: 10.1186/s40168-019-0685-7.
• Morigny P, Houssier M, Mairal A, Ghilain C, Mouisel E, Benhamed F, Masri B, Recazens E, Denechaud P-D, Tavernier G, Caspar-Bauguil S, Virtue S, Sramkova V, Monbrun L,Mazars A, Zanoun M, Guilmeau S, Barquissau V, Beuzelin D, Bonnel S, Marques M, Monge-Roffarello B, Lefort C, Fielding B, Sulpice T, Astrup A, Payrastre B, Bertrand-Michel J, Meugnier E, Ligat L, Lopez F, Guillou H, Ling C, Holm C, Rabasa-Lhoret R, Saris W H M, Stich V, Arner P, Rydén M, Moro C, Viguerie N, Harms M, Hallén S, Vidal-Puig A, Vidal H, Postic C, Langin D. Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity. Nature Metabolism 2019 1(1): 133-46. doi.org/10.1038/s42255-018-0007-6.
• Oh HYP, Ellero-Simatos S, Manickam R, Tan NS, Guillou H, Wahli W. Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase. Int J Mol Sci. 2019 20(4). pii: E812. doi: 10.3390/ijms20040812.
• Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B. Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol. 2019 pii: S0168-8278(19)30027-3. doi: 10.1016/j.jhep.2018.12.037.
• Piccinin E, Morgano A, Peres C, Contursi A, Bertrand-Michel J, Arconzo M, Guillou H, Villani G, Moschetta A. PGC-1α induced browning promotes involution and inhibits lactation in mammary glands. Cell Mol Life Sci. 2019. doi: 10.1007/s00018-019-03160-y.
• Zhang X, Grosfeld A, Williams E, Vasiliauskas D, Barretto S, Smith L, Mariadassou M, Philippe C, Devime F, Melchior C, Gourcerol G, Dourmap N, Lapaque N, Larraufie P, Blottière HM, Herberden C, Gerard P, Rehfeld JF, Ferraris RP, Fritton JC, Ellero-Simatos S, Douard V. Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism. FASEB J. 2019 33(6):7126-7142. doi: 10.1096/fj.201801526RR.
• Lahiri S, Kim H, Perez IG, Reza MM, Martin KA, Kundu PG, Cox LM, Selkrig J, Posma JM, Zhang H, Padmanabhan P, Moret C, Gulyás B, Blaser MJ, Auwerx J, Holmes E, Nicholson J, Wahli W, Pettersson S. The gut microbiota influences skeletal muscle mass and function in mice. Sci Transl Med. 2019 11(502). pii: eaan5662. doi: 10.1126/scitranslmed.aan5662.
• Cheng HS, Lee JXT, Wahli W, Tan NS. Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment. Mol Cancer. 2019 18(1):51. doi: 10.1186/s12943-019-0971-9.
• Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Després JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nuñez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner Ž, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokgözoğlu LS, Tomlinson B, Tybjærg-Hansen A, Valensi P, Vrablík M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby P. The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation. Cardiovasc Diabetol. 2019 18(1):71. doi: 10.1186/s12933-019-0864-7.
• Montagner A, Le Cam L, Guillou H. β-catenin oncogenic activation rewires fatty acid catabolism to fuel hepatocellular carcinoma. Gut. 2019 Feb;68(2):183-185. doi: 10.1136/gutjnl-2018-316557.
• Régnier M, Polizzi A, Guillou H, Loiseau N. Sphingolipid metabolism in non-alcoholic fatty liver diseases. Biochimie. 2019 159:9-22. doi: 10.1016/j.biochi.2018.07.021.
• Van Maele-Fabry G, Gamet-Payrastre L, Lison D. Household exposure to pesticides and risk of leukemia in children and adolescents: Updated systematic review and meta-analysis. Int J Hyg Environ Health. 2019 222(1):49-67. doi: 10.1016/j.ijheh.2018.08.004.
• Oh HYP, Visvalingam V, Wahli W. The PPAR-microbiota-metabolic organ trilogy to fine-tune physiology. FASEB J. 2019 33(9):9706-9730. doi: 10.1096/fj.201802681RR.
• Chalouati H, Ben Sâad MM, Payrastre L. Hepatoprotective effects of vitamin E against hexachlorobenzene-induced hepatotoxicity and oxidative stress in rats: histological, biochimical and antioxidant status changes. Toxicol Mech Methods. 2019 29(1):18-25. doi: 10.1080/15376516.2018.1506847.