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Toxalim

Zone de texte éditable et éditée et rééditée

Productions

1) Articles originaux dans des revues à comité de lecture

2018

  • Bossuet-Greif N, Vignard J, Taieb F, Mirey G, Dubois D, Petit C, Oswald E, Nougayrède JP. The colibactin genotoxin generates DNA interstrand cross-links in infected Cells. MBio. 2018 Mar 20;9(2). pii: e02393-17. doi: 10.1128/mBio.02393-17.

2017

  • Fernandez-Vidal A, Vignard J, Mirey G. Around and beyond 53BP1 Nuclear Bodies. Int J Mol Sci. 2017 Dec 5;18(12). pii: E2611. doi: 10.3390/ijms18122611. Review.
  • Liamin M, Boutet-Robinet E, Jamin EL, Fernier M, Khoury L, Kopp B, Le Ferrec E, Vignard J, Audebert M, Sparfel L. Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes. Biochem Pharmacol. 2017 Aug 1;137:113-124. doi: 10.1016/j.bcp.2017.04.025.

2016

  • Bezine E, Malaisé Y, Loeuillet A, Chevalier M, Boutet-Robinet E, Salles B, Mirey G, Vignard J (2016) Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms, Sci Rep. 6:36022. doi: 10.1038/srep36022.
  • Jullien D, Vignard J, Fedor Y, Béry N, Olichon A, Crozatier M, Erard M, Cassard H, Ducommun B, Salles B, Mirey G (2016) Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells, J Cell Sci. 129(13):2673-83. doi: 10.1242/jcs.183103.
  • Graillot V, Dormoy I, Dupuy J, Shay JW, Huc L, Mirey G, Vignard J (2016) Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis, Front Cell Infect Microbiol. 6:34. doi: 10.3389/fcimb.2016.00034.

2015

  • Lebailly P, Mirey G, Herin F, Lecluse Y, Salles B, Boutet-Robinet E (2015) DNA damage in B and T lymphocytes of farmers during one pesticide spraying season, Int Arch Occup Environ Health, 88:963-72.
  • Baldi I, Carles C, Blanc-Lapierre A, Fabbro-Peray P, Druet-Cabanac M, Boutet-Robinet E, Soulat JM, Bouvier G, Lebailly P (2015) A French crop-exposure matrix for use in epidemiological studies on pesticides: PESTIMAT, J Expo Sci Environ Epidemiol.
  • Bouley J, Saad L, Biard D, Grall R, Morel-Altmeyer, S. Guipaud O, Chambon C, Salles B, Maloum K, Merle-Béral H, Chevillard S and Delic J (2015) A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines, Oncotarget, 6:27980-8000.
  • Chalouati H, Boutet E, Metais B, Fouche E, Ben Sâad MM, Gamet-Payrastre L (2015) DNA damage and oxidative stress induced at low doses by the fungicide hexachlorobenzene in human intestinal Caco-2 cells, Toxicol Mech Methods, 12:1-11.

2014

  • Shamanna RA, Singh DK, Lu H, Mirey G, Keijzers G, Salles B, Croteau DL, Bohr VA (2014) RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex, Carcinogenesis, 35:2415-24.
  • Bezine E, Vignard J, Mirey G (2014) The cytolethal distending toxin effects on Mammalian cells: a DNA damage perspective, Cells, 3:592-615.
  • Trapp-Fragnet L, Bencherit D, Chabanne-Vautherot D, Le Vern Y, Remy S, Boutet-Robinet E, Mirey G, Vautherot JF, Denesvre C (2014) Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells, PLoS One.
  • Schiemann J, Steinberg P, Salles B (2014) Facilitating a transparent and tailored scientific discussion about the added value of animal feeding trials as well as in vitro and in silico approaches with whole food/feed for the risk assessment of genetically modified plants, Arch Toxicol. 88: 2067-2069.
  • Britton S, Dernoncourt E, Delteil C, Froment C, Schiltz O, Salles B, Frit P, Calsou P (2014) DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal, Nucleic Acids Res, 42: 9047-9062.

2013

  • Vignard J, Mirey G, Salles B (2013) Ionizing-radiation induced DNA double-strand breaks: a direct and indirect lighting up, Radiother Oncol, 108:362-369.
  • Fedor Y, Vignard J, Nicolau-Travers ML, Boutet-Robinet E, Watrin C, Salles B, Mirey G (2013) From single-strand breaks through double-strand breaks during S-phase: a new mode of action of the E. coli Cytolethal Distending Toxin, Cell Microbiol, 15, 1-15.
  • Cottarel J, Frit P, Bombarde O, Salles B, Négrel A, Bernard S, Jeggo PA, Lieber MR,  Modesti M, Calsou P (2013) A noncatalytic function of the ligation complex during Non-Homologous End Joining  J Cell Biol, 200, 173-186.
  • Fallone F, Britton S, Nieto L, Salles B, Muller C. ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression. Oncogene. 32, 4387-4396.
  • Salles B (2013) Inhibition of the non homologous end joining process in the context of hypoxic tumor cells, Transl. Cancer Res, 2(3), 215-226.

2012

  • Didier C, Demur C, Grimal F, Jullien D, Manenti S, Ducommun B. Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype. Cancer Biol Ther. 2012 Mar;13(5):307-13.
  • Courilleau C, Chailleux C, Jauneau A, Grimal F, Briois S, Boutet-Robinet E, Boudsocq F, Trouche D, Canitrot Y. The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks. J Cell Biol. 2012 Dec 24;199(7):1067-81.
  • Didier C, C Demur, F Grimal, D Jullien, S Manenti, B Ducommun. Evaluation of checkpoint kinase targeting therapy in acute myeloid leukemia with complex karyotype. Cancer Biol Ther. 2012 Mar;13(5):307-13.
  • Krietsch J, Caron MC, Gagné JP, Ethier C, Vignard J, Vincent M, Rouleau M, Hendzel MJ, Poirier GG, Masson JY. PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks. Nucleic Acids Res. 2012 Nov 1;40(20):10287-301.
  • Najib S, Saint-Laurent N, Estève JP, Schulz S, Boutet-Robinet E, Fourmy D, Lättig J, Mollereau C, Pyronnet S, Susini C, Bousquet C. A switch of G protein-coupled receptor binding preference from phosphoinositide 3-kinase (PI3K)-p85 to filamin A negatively controls the PI3K pathway. Mol Cell Biol. 2012 Mar;32(5):1004-16.

2011

  • Herin F, Boutet-Robinet E, Levant A, Dulaurent S, Manika M, Galatry-Bouju F, Caron P, Soulat JM. Thyroid function tests in persons with occupational exposure to fipronil. Thyroid. 2011 Jul;21(7):701-6:; IF=4,3
  • L Bochet, A Meulle, S Imbert, B Salles, P Valet and C Muller* (2011) Cancer-Associated adipocytes promotes breast tumor radioresistance, Biochem Biophys. Res. Comm. 411, 102-106; IF=2,6
  • Q Cheng, N Barboule, P Frit, D Gomez, O Bombarde, B Couderc,G Ren, B Salles*, P Calsou* Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks, Nucleic Acids Res. 39: 9605-19; IF 7,8
  • F Bouquet, M Ousset, D Biard, F Fallone, S Deauvillier, P Frit, B Salles* and C Muller* (2011) A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia, J Cell Sci., 124 : 1943-1951; IF=6,3
  • B Dirat, L Bochet, M Dabek, D Daviaud, S Dauvillier, B Majed, YY Wang, A Meulle, B Salles, S Le Gonidec, I Garrido, G Escourrou, P Valet and C Muller* (2011) Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion, Cancer Res. 71 : 2455-2465; IF 8,3

2) Conférences sur invitation

2018

  • Mirey G. Biotraceur chromatinien pour l'étude de la génotoxicité dans des cellules hépatiques métaboliquement compétentes. 32e journée Chimie-Biologie-Santé, 13 avril 2018, Toulouse.
  • Mirey G. Cytolethal Distending Toxin: mechanisms of action and perspectives. INRA Micalis, Jouy-en-Josas, 26 Janv. 2018.

2017

  • Mirey G. A new in vitro micronucleus test in living cells associating biological tracers and high-content imaging. ANSES, Maisons-Alfort, 10 Novembre 2017.
  • Mirey G. Contaminants alimentaires et Cancer. 33e Réunion Scientifique Annuelle de l'AFERO (Association Française d’étude et de recherche sur l’obésité)-PA3S (Pôle Aliment Sécurité Sanitaire & Santé), Toulouse, 20 Janv. 2017.

2016

  • Mirey G, "Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells", demi-journée Les avancées scientifiques Toulousaines, 21/11/2016

2013

  • Salles B, "Application des nanos dans l'alimentation et quelques éléments des rapports d'expertise sur la question", conférence dans le cadre de la journée du DIM NanoK, Université Paris-Diderot, 10/12/2013
  • Salles B, "Biomarkers of genotoxicity in food safety", TRANSBIO SUDOE on Molecular Medicine and agrofood innovation, Montpellier 26 et 27/09/2013
  • Mirey G, Bacterial Cytolethal Distending Toxin effects on mammalian cells: a DNA damage and repair perspective. Institut Pasteur, Paris, 21 Octobre 2013
  • Mirey G, Génotoxicité et cancérogenèse : dommages oxydatifs, cassures double-brin et génotoxines. Pôle Aliment Sécurité Sanitaire & Santé (PA3S), Toulouse, 21 Mars 2013
  • Salles B, "Cassures double-brin de l'ADN: production, suivi et réparation", séminaire INSERM U775, Faculté de Médecine St Pères, 15/01/2013

2012

  • Salles B, Contributeur au forum "aliment-chimie" organisé par la mission d'animation des agrobiosciences, bibliothèque de Nailloux, le 23/03/2012
  • Salles B, "Inhibition de la réparation des cassures de l'ADN: quel intérêt en radiothérapie et pharmacologie antitumorale?" conférence, Académie Vétérinaire de France, Paris, 21/06/2012

2011

  • Mirey G, Vers le développement de Biotraceurs de génotoxicité, INRA Tours-Nouzilly, 7 Février 2011

2010

  • Salles B - Cell repair capacity controls SAF-A/hnRNP-U phosphorylation by DNA-PK in response to DNA double strand breaks inducers in « International Conference on Biomedical Sciences and Technology » meeting , Beijing, China May 9th to 12th, 2010
  • Salles B - Le complexe majeur de réparation des cassures de l'ADN : cible pharmacologique?, INSERM U889 et EICB, Bordeaux, 13/04 2010

3) Communications orales à des congrès internationaux et nationaux

2017

  • Jullien D, Vignard J, Fedor Y, Olichon A, Crozatier M, Salles B, Ducommun B, Mirey G. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. 7th Annual Meeting of the Biosensor Group, Toulouse 1-2 June 2017.

2015

  • Martin O, Chevalier M, Tache S, Naud N, Salles B, Mirey G, Pierre F, Boutet-Robinet E. "In vivo genotoxic effects of dietary heme iron on rat colon mucosa and ex vivo effects on colon cells monitored by an optimized alkaline comet assay". 11th International Comet Assay Workshop, Antwerp, Belgium, 1st-4th September 2015

2014

  • Jullien D, Vignard J, Fedor Y, Olichon A, Salles B, Ducommun B, Mirey G. "VHH-based universal histone binding domains: novel tools for a different look on and manipulation of chromatin". FEBS EMBO 2014 Conférence, Paris, France, 30 August-4 September 2014.
  • Jullien D, Vignard J, Fedor Y, Olichon A, Crozatier M, Salles B, Ducommun B, Mirey G. "Nanobody-based universal histone binding domains for chromatin imaging and editing". 4th Annual Meeting of the Biosensor Group - GDR 2588 Microscopie et Imagerie du Vivant, Bordeaux, 22-23 May 2014.

2013

  • Salles B. "A new way to follow the production of DNA double-strand breaks in cells in real time", conférence, 13th International Wolfsberg Meeting on Molecular Radiation Biology / Oncology, 22-24/06/2013
  • Lebailly P, Mirey G, Herin F, Lecluse Y, Salles B, Boutet-Robinet E. "Genotoxic stress in B- and T-lymphocytes of farmers during one spraying season". International 10th Comet Assay Workshop 18-20 Septembre 2013, Porto (Portugal)
  • Trapp-Fragnet L., Vautherot D., Le Vern Y., Rémy S., Boutet-Robinet E., Mirey G., Vautherot J.F.,Denesvre C. Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells. 4th ESVV Veterinary Herpesvirus Symposium 17-18 January 2013, Zurich (Switzerland)
  • C. Courilleau, C. Chailleux, A. Jauneau, F. Grimal, S. Briois, E. Boutet-Robinet, F. Boudsocq, D. Trouche, Y. Canitrot. The chromatin remodeler p400 ATPase facilitates rad51 mediated repair of DNA double-strand breaks. Third Cell cycle and cancer meeting, April 2-5, 2013. Montpellier (France).

2012

  • D. Jullien, J. Vignard, G. Mirey, B. Ducommun Développement de nouveaux outils de détection non-invasive des cassures double brin de l’ADN. Réunion du groupe Biosenseur GDR2588 – Montpellier 15 – 16 Mars 2012
  • Trapp-Fragnet L., Vautherot D., Le Vern Y., Rémy S., Vautherot J.F., Boutet E., Mirey G., Denesvre C. Régulation du cycle cellulaire de la maladie de Marek : implication de la protéine de tégument VP22 dans l'arrêt prolifératif en phase-S. Journée scientifique de l'association HerPAS. 28 mars 2012. Paris
  • Trapp-Fragnet L., Vautherot D., Le Vern Y., Rémy S., Boutet-Robinet E., Mirey G., Vautherot J.F., Denesvre C. Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells. 9th International Symposium on Marek's Disease and Avian Herpesviruses. 24-28 Juin, 2012, Berlin (Germany)

2011

  • D. Jullien, B. Bugler, C. Dozier, B. Ducommun Des isoformes spéciales de CDC25B pour le redémarrage “à froid” du cycle cellulaire 2nd Workshop de l’axe 2 “Génome, Structure et Fonction“ du Cancéropôle du grand Sud Ouest, Mars 2011
  • Fedor Y, A Olichon, G Favre, B Ducommun, B Salles, G Mirey. A diagnostic tool to assess genotoxic activity ex vivo. Paris Eurotox 2011, 47th Congress of the European Societies of Toxicology
  • Courilleau C., Chailleux C., Jauneau A., Boutet-Robinet E., Boudsocq F., Trouche D., Canitrot Y. "Remodelling chromatin p400 ATPase, facilitates the repairing of double-strand breaks dependent on rad51". 7èmes Journées du Cancéropole du Grand Sud Ouest. 18-20 octobre 2011, Bordeaux

2010

  • F Herin, E Boutet, S Dulaurent, F Galatry-Bouju, P Caron, J-M Soulat. Exposition professionnelle au fipronil et marqueurs de la fonction thyroïdienne. 31e Congrès national de médecine et santé au travail Toulouse 1er au 4 juin 2010

4)Communications affichées à des congrès internationaux et nationaux

2017

  • Graillot V, Mondesert O, Méténier T, Vignard J, Lobjois V, Bazin E, Schevchenko V, Guillouzo C, Chesne C, Ducommun B, Salles B, Mirey G. In vitro micronucleus test in living cells associating biological tracers and high-content imaging. 53rd Congress of the European Societies of Toxicology (Eurotox), Bratislava, Slovaquie, 10-13 Sept. 2017.

2016

  • Graillot V, Mondesert O, Metenier T, Vignard J, Lobjois V, Bazin E, Shevchenko V, Guillouzo C, Chesne C, Ducommun B, Salles B, Mirey G. A new in vitro micronucleus test in living cells associating biological tracers and high-content imaging. 52nd Congress of the European Societies of Toxicology (EUROTOX) Sevilla, Spain, 2016.
  • Steen DM, Graillot V, Mondesert O, Méténier T, Vignard J, Lobjois V, Bazin E, Schevnchenko V, Guillouzo C, Chesne C, Ducommun B, Salles B, Mirey G. A new in vitro micronucleus test in living cells associating biological tracers and high-content imaging. 47th Annual Meeting of the Environmental-Mutagenesis-and-Genomics-Society, Kansas City, MO, USA, 24-28 Sept. 2016.

2015

  • Vignard J, Bezine E, Boutet-Robinet E, Chevalier M, Salles B, Mirey G. Overview of the DNA repair pathways involved in the response to the Cytolethal Distending Toxin. 11th 3R Meeting, Presqu'île de Giens, France, 04-07 May 2015.
  • Bezine E, Vignard J, Chevalier M, Boutet-Robinet E, Salles B, Mirey G. Overview of the DNA repair pathways involved in response to the Cytolethal Distending Toxin. The 6th EMBO Meeting, Birmingham, Angleterre, 05-08 September 2015.

2014

  • Bezine E, Fedor Y, Vignard J, Boutet-Robinet E, Salles B, Mirey G. A new mode of action for the Cytolethal Distending Toxin. USA Society of Toxicology’s 53rd Annual Meeting, Phoenix, USA. 24-27 Mars 2014.
  • Bezine E, Fedor Y, Vignard J, Boutet-Robinet E, Salles B, Mirey G. The Bacterial Cytolethal Distending Toxin: a nuclease inducing indirect DNA double-strand breaks into eukaryotic cells. FEBS-EMBO 2014 Meeting, Paris, France. 30 Août-04 Septembre 2014.

2013

  • Fedor Y, Vignard J, Bezine E, Nicolau-Travers M-L, Boutet E, Salles B, Mirey G. From single-strand breaks to double-strand breaks trough the S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin. German-French DNA repair meeting on Epigenetics and Genome Integrity, Illkirch. 7-10 octobre 2013.
  • Bezine E, Fedor Y, Vignard J, Boutet-Robinet E, Salles B, Mirey G. A new mode of action for the Cytolethal Distending Toxin. 5th EMBO Meeting, Amsterdam, Netherlands. 21-24 septembre 2013.
  • Courilleau C, Chailleux C, Jauneau A, Grimal F, Briois S, Boutet-Robinet E, Boudsocq F, Trouche D, Canitrot Y. The chromatin remodeler p400 ATPase facilitates Rad51 mediated repair of DNA double-strand breaks. 10ème colloque des 3R, Giens, France. 21-24 mai 2013.
  • Fedor Y, Vignard J, Bezine E, Nicolau-Travers M-L, Boutet E, Salles B, Mirey G. From single-strand breaks to double-strand breaks trough the S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin. 10e colloque des 3R, Giens, France. 21-24 mai 2013.
  • Courilleau C, Chailleux C, Jauneau A, Grimal F, Briois S, Boutet-Robinet E, Boudsocq F, Trouche D, Canitrot Y. The chromatin remodeler p400 ATPase facilitates Rad51 mediated repair of DNA double-strand breaks. Cancer Cell Death and Resistance congress, Seilh, France. 6-7 mai 2013.
  • D. Jullien, J. Vignard, Y. Fedor, A. Olichon, B. Ducommun, B. Salles, G. Mirey Development of single chain antibodies against gamma H2AX Réunion du groupe Biosenseur GDR2588 – Marseille (France)
  • D. Jullien, J. Vignard, Y. Fedor, A. Olichon, B. Ducommun, B. Salles, G. Mirey Development of single chain antibodies against gamma H2AX Third Cell cycle and cancer meeting, April 2-5, 2013. Montpellier (France).

2012

  • Fedor Y, Vignard J, Bezine E, Nicolau-Travers M-L, Boutet E, Salles B, Mirey G. From single-strand breaks to double-strand breaks trough the S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin. 42nd EEMS Annual Conference, Septembre 2012, Varsovie (Pologne)
  • Bezine E, Fedor Y, Vignard, Boutet-Robinet E, Salles B, Mirey G. Effets génotoxiques de la Cytolethal Distending Toxin et mécanismes de signalisations. Journées des microbiologistes de l'INRA. Novembre 2012, L'Isle-sur-la-Sorgue.

2011

  • Fedor Y, Olichon A, Favre G, Ducommun B, Salles B, Mirey G. Détection des cassures double brin en temps réel : un nouvel outil. 9e colloque des 3R 2011 mai 2011 Giens.