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Zone de texte éditable et éditée et rééditée

Productions scientifiques de l'équipe

Publications par année des membres de l'équipe

Le membres de l'équipe sont indiqués en gras


  • Da Silva EO, Bracarense APFRL, Oswald IP. 2018. Mycotoxins and oxydative stress: where are we? World Mycotoxin J. 11(1):113-134 .
  • El Hajj Assaf C, Snini SP, Tadrist S, Bailly S, Naylies C, Oswald IP, Lorber S, Puel O. 2018. Impact f veA on the development, aggressiveness, dissemination and secondary metabolism of Penicillium expansum. Mol. Plant Pathol. doi: 10.1111/mpp.12673.
  • Garcia GR, Payros D, Pinton P, Dogi CA, Laffitte J, Neves M, Gonzalez Pereyra ML, Cavaglieri LR, Oswald IP. 2018. Intestinal toxicity of deoxynivalenol is limited by Lactobacillus rhamnosus RC007 in pig jejunum explants. Arch. Toxicol. 92(2): 883-993.
  • Gratz SW, Currie V. Richardson AJ, Duncan G, Holtrop G, Farquharson F, Louis P, Pinton P, Oswald IP. 2018. Porcine small and large intestinal microbiota rapidly hydrolyze the masked mycotoxin deoxynivalenol-3-glucoside and release deoxynivalenol in vitro. Appl. Env. Microbiol. 84(2): e02106-17.
  • Hautbergue T, Jamin EL, Debrauwer L, Puel O, Oswald IP. 2018. From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites. Nat. Prod. Rep. 35: 147-173.
  • Le TH, Alassane-Kpembi I, Pinton P, Oswald IP. 2018. Analysis of the interactions between environmental and food contaminants, cadmium and deoxynivalenol, in different target organs. Sci. Tot. Environ. 622-623: 841-848.
  • Liber Y., Létondor C., Pascal-Lorber S., Laurent F. 2018. Growth parameters influencing uptake of chlordecone by Miscanthus species. Sci. Total Environ. 624C: 831-837.
  • Maruo VM, Bracarense AP, Metayer JP, Vilarino M, Oswald IP, Pinton P. 2018. Ergot Alkaloids at doses close to EU regulatory limits induce alterations of the liver and intestine. Toxins (Basel) 10(5). pii: E183.
  • Moore GG, Mack BM, Beltz SB, Puel O. 2018. Genome sequence of an aflatoxigenic pathogen of Argentinian peanut, Aspergillus arachidicola. BMC Genomics 19(1): 189.
  • Soler L, Oswald IP. The importance of accounting for sex in the search of proteomic signatures of mycotoxin exposure. J Proteomics 178: 114-122. doi : 10.1016/j.jprot.2017.12.017.
  • Tannous J, Keller NP, Atoui A, El Khoury A, Lteif R, Oswald IP, Puel O. 2018. Secondary Metabolism in Penicillium expansum: Emphasis on Recent Advances in Patulin Research. Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408398.
  • Theumer MG, Henneb Y, Khoury L, Tadrist S, Canler C, Puel O, Oswald IP, Audebert M. 2018. Genotoxicity of aflatoxins and their precurosrs in human cells. Toxicol. Lett. 287: 100-107.


  • Alassane-Kpembi I, Gerez JR, Cossalter AM, Neves M, Laffitte J, Naylies C, Lippi Y, Kolf-Clauw M, Bracarense APL, Pinton P, Oswald IP. 2017. Intestinal toxicity of the type B trichothecene mycotoxin fusarenon-X: whole transcriptome profiling reveals new signaling pathways. Sci. Rep. 7(1):7530.
  • Alassane-Kpembi I, Puel O, Pinton P, Cossalter AM, Chou TC, Oswald IP. 2017. Co-exposure to low doses of the food contaminants deoxynivalenol and nivalenol has a synergistic inflammatory effect on intestinal explants. Arch. Toxicol. 91(7): 2677-2687.
  • Alassane-Kpembi I, Schatzmayr G, Taranu D, Marin D, Puel O, Oswald IP. 2017. Mycotoxins co-contamination: Methodological aspects and biological relevance of combined toxicity studies. Crit. Rev. Food Sci. Nutr. 57(16): 3489-3507.
  • Aleksic B, Draghi M, Ritoux S, Bailly S, Lacroix M, Oswald IP, Bailly JD, Robine E. 2017. Aerosolization of mycotoxins after growth of toxinogenic fungi on wallpaper. Appl Environ Microbiol. pii: AEM.01001-17.
  • Bracarense APFL, Basso KM, da Silva EO, Payros D, Oswald IP. 2017. Deoxynivalenol in the liver and lymphoid organs of rats: effects of dose and duration on immunohistological changes. World Mycotoxin J. 10(1): 89-96.
  • Caceres I, El Khoury R, Bailly S, Oswald IP, Puel O, Bailly JD. 2017. Piperine inhibits aflatoxin B1 production in Aspergillus flavus by modulating fungal oxidative stress response. Fungal Genet. Biol. 107:77-85.
  • Carvajal-Campos A, Manizan AL, Tadrist S, Koffi Akaki D, Koffi-Nevry R, Moore GG, Fapohunda SO, Bailly S, Montet D, Oswald IP, Lorber S, Brabet C, Puel O. Aspergillus korhogoensis, a novel aflatoxin producing species from the Côte d’Ivoire. Toxins, 9, 353, doi: 10.3390/toxins9110353.
  • Combes S, Massip K, Martin O, Furbeyre H, Cauquil L, Pascal G, Bouchez O, Le Floch N, Zemb O, Oswald IP, Gidenne T. 2017. Impact of feed restriction and housing hygiene conditions on specific and inflammatory immune response, the cecal bacterial community and the survival of young rabbits. Animal. 11(5): 854-863.
  • De Pascali SA, Gambacorta L, Oswald IP, Del Coco L, Solfrizzo M, Fanizzi FP. 2017. 1H NMR and MVA metabolomic profiles of urines from piglets fed with boluses contaminated with a mixture of five mycotoxins. Biochem. Biophys. Rep. 11: 9-18.
  • El Khoury R, Caceres I, Puel O, Bailly S, Atoui A, Oswald IP, El Khoury A, Bailly JD. 2017. Identification of a new anti-aflatoxinogenic aqueous extract from Micromeria graeca and elucidation of its molecular mechanism in Aspergillus flavus. Toxins. 9(3). pii: E87.
  • Hautbergue T, Puel O, Tadrist S, Meneghetti L, Péan M, Delaforge M, Debrauwer L, Oswald IP, Jamin EL. 2017. Evidencing 98 secondary metabolites of Penicillium verrucosum using substrate isotopic labeling and high-resolution mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1071: 29-43.
  • Hymery N, Puel O, Tadrist S, Canlet C, Le Scouarnec H, Coton E, Coton M. 2017. Effect of PR toxin on TPH1 and Caco-2 cells: an in vitro study. World Mycotox. 10(4): 375-386.
  • Myers RR, Smith TD, Elsawa SF, Puel O, Tadrist S, Calvo AM. rtfA controls development, secondary metabolism, and virulence in Aspergillus fumigatus. 2017. PloS One. 12(4): e0176702.
  • Payros D, Dobrindt U, Martin P, Secher T, Bracarense APFL, Boury M, Laffitte J, Pinton P, Oswald E, Oswald IP. 2017. Food contaminant deoxynivalenol exacerbates the genotoxicity of gut microbiota. mBio. 8(2): e00007-17.
  • Régnier M, Gourbeyre P, Pinton P, Napper S, Laffitte J, Cossalter AM, Bailly JD, Lippi Y, Bertrand-Michel J, Bracarense APFRL, Guillou H, Loiseau N, Oswald IP. 2017. Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine. Mol. Nutr. Food Res. 61(12): 1700433.
  • Robert H, Payros D, Pinton P, Théodorou V, Mercier-Bonin M, Oswald IP. 2017. Mucus and Microbiota as key partners of the intestinal barrier function: new targets for mycotoxins? J. Toxicol. Env. Health, Part B: Crit. Rev. 20(5): 249-275.
  • Souto PCMC, Jager AV, Tonin FG, Petta T, Di Gregorio MC, Cossalter AM, Pinton P, Oswald IP, Rottinghaus GE, Oliveira CAF. 2017. Determination of fumonisin B1 levels in body fluids and hair from piglets fed fumonisin B1-contaminated diets. Food Chem. Toxicol. 108(Pt A):1-9.
  • Tannous J, Snini S, El Khoury R, Canlet C, Pinton P, Lippi Y, Alassane‑Kpembi I, Gauthier T, El Khoury A, Atoui A, Zhou T, Lteif R, Oswald IP, Puel O. 2017. Patulin transformation products and last intermediates in its biosynthetic pathway, E‑ and Z‑ascladiol, are not toxic to human cells. Arch. Toxicol. 91(6): 2455-2467.


  • Alassane-Kpembi I, Oswald IP. 2016. Toxicological interactions between mycotoxins. In Food Contaminants and Human Health: Challenges in chemical mixtures. Edited by P Alvito, R Assunção, H Louro, M João Silva and E Vasco. pp 94-98.
  • Aleksic B, Bailly S, Draghi M, Pestka JJ, Oswald IP, Robine E, Bailly JD, Lacroix MZ. 2016. Production of four macrocyclic trichothecenes by Stachybotrys chartarum during its development on different building materials as measured by UPLC-MS/MS. Build. Environ. 106: 265-273.
  • Amuzie C, Bandyopadhyay R, Bhat RV, Black R, Burger H, Cardwell KF, Gelderblom W, Gong YY, Groopman JD, Kimanya M, Miller JD, Oswald I, Pascale M, Payne GA, Phillips TD, Riley R, Shephard GS, Stoltzfus R, Sugita-Konishi Y, Turner PC, Wogan GN, Wu F. 2016. Mycotoxin control in low- and milddle income countries. IARC working group report N°9. Edited by C.P. Wild, J.D. Miller and J.D. Groopman. 54 pp.
  • Caceres I, El Khoury R, Medina A, Lippi Y, Naylies C, Atoui A, El Khoury A, Oswald IP, Bailly JD, Puel O. 2016. Deciphering the anti-aflatoxinogenic properties of eugenol using a large scale qPCR approach. Toxins 8: 123.
  • Cano PM, Puel O, Oswald IP. 2016. Mycotoxins: Fungal Secondary Metabolites with Toxic Properties. In Fungi: Applications and management strategies. Edited by Deshmukh SK, Misra JK, Tewari JP, Papp T: pp 318-371.
  • Cheat S, Oswald IP, Kolf-Clauw M. 2016. Mycotoxin Outbreak in Animal Feed in Foodborne Diseases: Case studies of outbreaks in agri-food industries. Edited by JM Soon, L Manning and C Wallace. pp 257-285.
  • Cheat S, Pinton P, Cossalter AM, Cognié J, Callu P, Vilarano M, Raymond-Letron I, Oswald IP, Kolf-Clauw M. 2016. The mycotoxins deoxynivalnol and nivalenol show in vivo synergism on jejunum enterocytes apoptosis. Food Chem. Toxicol. 87: 45-54.
  • Gambacorta L, Pinton P, Avantaggiato G, Oswald IP, Solfrizzo M. 2016. Grape pomace, an agricultural by-product reducing mycotoxins absorption: in vivo assessment in pig using urinary biomarkers. J Agri Food Chem. 64: 6762-6771.
  • Herrera M, Anadon R, Iqbal SZ, Bailly JD, Arino A. 2016. Climate change and food safety. In Food safety, Basic concepts, recent issues and future challenges. Selamat and Iqbal (ed), Springer, pp 149-160.
  • Karlovsky P, Suman M, Berthiller F, De Meester J, Eisenbrand G, Perrin I, Oswald IP, Speijers G, Chiodini A, Recker T, Dussort P. 2016. Impact of food processing and detoxification treatments on mycotoxin contamination. Mycotoxin Res. 32: 179-205.
  • Knudsen C, Combes S, Mousavikhorshidi H, Oswald IP, Gidenne T. 2016. An LPS based method to stimulate the inflammatory response in growing rabbits. World Rabbit J. 24: 55-65.
  • Maidana L, Gerez JR, El Khoury R, Pinho F, Puel O, Oswald IP, Bracarense APFL. 2016. Effect of patulin and ascladiol on intestinal mucosa: an ex vivo approach. Food Chem. Toxicol. 98:189-194.
  • Pascal-Lorber S, Létondor C, Liber Y, Laurent F. 2016. Uptake and distribution of chlordecone in maize shoots. J. Agric. Food Chem. 64: 409-415.
  • Payros D, Alassane-Kpembi I, Pierron A, Loiseau N, Pinton P, Oswald IP. 2016. Toxicology of deoxynivalenol and its acetylated and modified forms. Arch. Toxicol. 90: 2931-2957.
  • Pierron A., Alassane-Kpembi I., Oswald IP. 2016. Impact of two mycotoxins Deoxynivalenol and Fumonisin on pig intestinal health. Porcine Health Manag. 2: 21.
  • Pierron A, Alassane-Kpembi I, Oswald IP. 2016. Impact of mycotoxin on immune response and consequences for pig health. Animal Nutr. 2: 63-68.
  • Pierron A, Mimoun S, Murate LS, Loiseau N, Lippi Y, Bracarense APFL, Liaubet L, Schatzmayr G, Berthiller F, Moll WD, Oswald IP. 2016. Intestinal toxicity of the masked mycotoxin deoxynivalenol-3-B-D-glucoside. Arch. Toxicol. 90: 2037-2046.
  • Pierron A, Mimoun S, Murate LS, Loiseau N, Lippi Y, Bracarense APFL, Schatzmayr G, He J, Zhou T, Moll WD, Oswald IP. 2016. Microbial biotransformation of DON: molecular basis for reduced toxicity. Sci. Rep. 6: 29105.
  • Snini SP, Tannous J, Heuillard P, Bailly S, Lippi Y, Zheraoui E, Barreau C, Oswald IP, Puel O. 2016. The patulin is a cultivar dependant aggressiveness factor favoring the colonization of apples by Penicillium expansum. Mol. Plant. Pathol. 17: 920-930.
  • Tannous J, Atoui A, El Khoury A, Ziad F, Oswald IP, Puel O, Lteif R. 2016. A study on the physicochemical parameters for Penicillium expansum growth and patulin production: Effect of temperature, pH and water activity. Food Sci. Nutr. 4: 611-622.


  • Adjovi YCS, Gnonlonfin BJG, Bailly S, Bailly JD, Tadrist S, Puel O, Oswald IP, Sanni A. 2015. Occurrence of mycotoxins in cassava (Manihot esculenta Crantz) and its products. Int J Food Safety, Nutr Public Health. 5: 217-247.
  • Alassane-Kpembi I, Puel O, Oswald IP. 2015. Toxicological interactions between the mycotoxins deoxynivalenol, nivalenol and their acetyl derivatives in intestinal epithelial cells. Arch. Toxicol. 89: 1337-1346.
  • Cheat S, Gerez JR, Cognié J, Alassane-Kpembi I, Bracarense APFL, Raymond-Letron I, Oswald IP, Kolf-Clauw M. 2015. Nivalenol has a greater impact than deoxynivalenol on pig jejunum mucosa in vitro on explants and in vivo on intestinal loops. Toxins 7: 1945-1961
  • Fontaine K, Hymery N, Lacroix MZ, Puel S, Puel O, Rigalma K, Gaydou V, Coton E, Mounier J. 2015. Influence of intraspecific variability and abiotic factors on mycotoxin production in Penicillium roqueforti. Int. J. Food Microbiol. 215: 187-193.
  • Gerez JR, Pinton P, Callu P, Grosjean F, Oswald IP, Bracarense APFL. 2015. Deoxynivalenol alone or in combination with nivalenol and zearalenone induce systemic histological changes in pigs. Exp. Toxicicol. Pathol. 67: 89-98.
  • Gourbeyre P, Berri M, Lippi Y, Meurens F, Vincent-Naulleau S, Laffitte J, Rogel-Gaillard C, Pinton P, Oswald IP. 2015. Pattern recognition receptors in the gut: analysis of their expression along the intestinal tract and the crypt/villus axis. Physiol Report 3: e12225.
  • Graziani F, Pujol A, Nicoletti C, Pinton P, Armand L, Di Pasquale E, Oswald IP, Perrier J, Maresca M. 2015. The food-associated ribotoxin deoxynivalenol modulates the expression of the inducible NO synthase by the human intestinal epithelium. Toxicol. Sci. 145: 372–3821.
  • Jacquier V, Estellé J, Panneau B, Lecardonnel J, Moroldo M, Lemonnier G, Turner-Maier J, Duranthon V, Oswald IP, Gidenne T, Rogel-Gaillard C. . 2015. Genome-wide immunity studies in the rabbit: transcriptome variations in PBMCs after in vitro stimulation by LPS or PMA-ionomycin. BMC Genomics. 16: 26.
  • Knudsen C, Combes S, Briens C, Duperray J, Rebours G, Salaun JM, Travel A, Weissman D, Gidenne T, Oswald IP. 2015. Quantitative feed restriction rather than caloric restriction modulates the immune response of the growing rabbit. J. Nutr. 145: 483-9.
  • Levasseur-Garcia C, Bailly S, Kleiber D, Bailly JD. 2015. Assessing Risk of Fumonisin Contamination in Maize Using Near-Infrared Spectroscopy. J. Chem. : Article ID 485864.
  • Loiseau N, Polizzi A, Dupuy A, Therville N, Rakotonirainy M, Loy J, Viadere JL, Cossalter AM, Bailly JD, Puel O, Kolf-Clauw M, Bertrand-Michel J, Levade T, Guillou H, Oswald IP. 2015. New insights in the organ-specific adverse effects of Fumonisin B1: comparison between lung and liver. Arch. Toxicol. 89: 1619-1629.
  • Pinton P, Graziani F, Pujol A, Nicoletti C, Paris O, Ernouf P, Di Pasquale E, Perrier J, Oswald IP, Maresca M. 2015. Deoxynivalenol inhibits the expression by goblet cells of intestinal mucins through a PKR and MAP kinase-dependent repression of the resistin-like molecule β. Mol. Food Nutr. Res. 59: 1076-1087.
  • Tannous J, Atoui A, El Khoury A, Kantar S, Chdid N, Lippi Y, Oswald IP, Puel O, Lteif R. 2015. Development of a Real-Time PCR assay for Penicillium expansum quantification and patulin estimation in apples. Food Microbiol. 50: 28-37.


  • Adjovi YCS, Bailly S, Gnonlonfin BJG, Tadrist S, Querin A, Sanni A, Oswald IP, Puel O, Bailly JD. 2014. Analysis of the contrast between natural occurrence of toxigenic Aspergillus of the flavi section and aflatoxin B1 in cassava. Food Microbiol. 38: 151-159.
  • Cabaret O, Puel O, Botterel F, Delaforge M, Bretagne S. 2014. Metabolic detoxication pathways for methoxy-sterigmatocystin in primary tracheal epithelial cells. Xenobiotica 44: 1-9.
  • Finamore A, Roselli M, Imbinto A, Seeboth J, Oswald IP, Mengheri E. 2014. Lactobacillus amylovorus inhibits the TLR4 inflammatory signaling triggered by enterotoxigenic Escherichia coli via modulation of the negative regulators and involvement of TLR2 in intestinal Caco-2 cells and pig explants. PlosOne 9: e94891.
  • Jacquier V, Combes S, Oswald IP, Rogel-Gaillard C, Gidenne T. 2014. Early modulation of the cecal microbial activity in the young rabbit with rapidly fermentable fiber: impact on health and growth. J. Anim. Sci. 92: 5551-9.
  • Mach N, Berri M, Esquerré D, Lemonnier G, Billon Y, Lepage P, Oswald IP, Doré J, Rogel-Gaillard C, Estellé J. 2014. Extensive expression differences along porcine small intestine evidenced by transcriptome sequencing. PlosOne 9: e88515.
  • Miller JD, Schaafsma AW, Bhatnagar D, Bondy G, Carbone I, Harris L, Harrison G, Munkvold G, Oswald IP, Pestka J, Sharpe L, Sumarah M, Tittlemier S, Zhou T. 2014. Mycotoxins that affect the North American Agri-Food sector: state of the art and directions for the future. World Mycotoxin J. 7: 63-82.
  • Pinton P, Oswald IP. 2014. Effect of doexynivalenol and other type B trichothecenes on the intestine: a review. Toxins 6: 1615-1643.
  • Snini S, Tadrist S, Lafitte J, Jamin EL, Oswald IP, Puel O. 2014. The gene PatG, involved in biosynthesis pathway of patulin, a food-borne mycotoxin, encodes a 6-methylsalicylic acid decarboxylase. Int. J. Food Microbiol. 171: 77-83.
  • Tannous J, El Khoury R, Snini SP, Lippi Y, El Khoury A, Atoui A, Lteiff R, Oswald IP, Puel O. 2014. Sequencing, physical organization and kinetic expression of the patulin biosynthetic gene cluster from Penicillium expansum. Int. J. Food Microbiol. 189: 51-60.


  • Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, Abrami R, Abiola FA, Oswald IP, Puel O. 2013. New insight into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes against intestinal epithelial cells is synergistic. Tox. Appl. Pharmacol. 272: 191-198.
  • Bekhouche F., Merabti R., Bailly JD. 2013. Traditional couscous manufacture from fermented wheat (Algeria): process and technological and nutritional quality. Afr. J. Sci. Technol. 4: 167-175.
  • Berthiller F, Crews C, Dall'Asta C, De Saeger S, Haesaert G, Karlovsky P, Oswald IP, Seefelder W, Speijers G, Stroka J. 2013. Masked Mycotoxins: A review. Mol. Nutr. Food Res. 57: 165–86.
  • Burel C, Tanguy M, Guerre P, Boilletot E, Cariolet R, Queguiner M, Postollec G, Pinton P, Oswald IP, Fravalo P. 2013. Effect of low dose of fumonisins on pig health: immune status, intestinal microbiota and sensitivity to Salmonella. Toxins 5: 841-864.
  • Cano PM, Jamin EL, Tadrist S, Bourdaudhui P, Péan M, Debrauwer L, Oswald IP, Delaforge M, Puel O. 2013. New untargeted metabolic profiling combining mass spectrometry and isotopic labeling: application on Aspergillus fumigatus grown on wheat. Anal. Chem. 85: 8412-20.
  • Cano P*, Seeboth J*, Meurens F, Cognie J, Abrami R, Oswald IP, Guzylack-Piriou L. 2013. Deoxynivalenol as a new factor in the persistence of intestinal inflammatory diseases : an emerging hypothesis through possible modulation of Th17-mediated response. PlosOne 8: e53647. * Equally contributed
  • El Mahgubi A, Puel O, Bailly S, Tadrist S, Querin A, Ouadia A, Oswald IP , Bailly JD. 2013. Distribution and toxigenicity of Aspergillus section Flavi in spices marketed in Morocco. Food Control 32: 143-8.
  • Gaige S, Bonnet MS, Tardivel C, Pinton P, Trouslard J, Jean A, Guzylack L, Troadec JD, Dallaporta M. 2013. c-Fos immunoreactivity in the Pig brain following deoxynivalenol intoxication: focus on NUCB2/nesfatin-1 expressing neurons. Neurotoxicology 34: 135-49.
  • Gambacorta L, Solfrizzo M, Viconti A, Powers S, Cossalter AM, Pinton P, Oswald IP. 2013. Validation of urinary biomarkers of exposure for aflatoxin B1, ochratoxin A, fumonisin B1, deoxynivalenol and zearalenone in piglets. World Mycotoxin J. 6: 299-30.
  • Gauthier T, Waché Y, Laffitte J, Taranu I, Saeedikouzehkonani N, Mori Y, Oswald IP. 2013. Deoxynivalenol impairs the immune functions of porcine neutrophils. Mol. Nutr. Food Res. 57: 1026-36.
  • Grenier B, Bracarense APFL, Schwartz HE, Lucioli J,Cossalter AM, Moll WD, Schatzmayr G, Oswald IP. 2013. Biotransformation approaches to alleviate the effects induced by Fusarium mycotoxins in swine. J. Agr. Food Chem. 61: 6711-6719.
  • Kolf-Clauw M, Sassahara M, Lucioli J, Rubira-Gerez J, Alassane-Kpembi I, Lyazhri F, Borin C, Oswald IP. 2013. The emerging mycotoxin, enniatin B1, down-modulates the digestive toxicity of T-2-toxin in vitro on intestinal epithelial cells and ex-vivo on intestinal explants. Arch. Toxicol. 87: 2233–2241.
  • Lucioli J, Pinton P, Callu P, Laffitte J, Grosjean F, Kolf-Clauw M, Oswald IP, Bracarense AP. 2013. The food contaminant deoxynivalenol activates the mitogen activated protein kinases in the intestine: comparison of in vivo and ex vivo models. Toxicon 66: 31-6.
  • Mach N, Gao Y, Lemonnier G, Lecardonnel J, Oswald IP, Estellé J, Rogel-Gaillard C. 2013. The peripheral blood transcriptome reflects variations in immunity traits in swine: toward identification of biomarkers. BMC Genomics 14: 894.


  • Bracarense AP, Lucioli J, Grenier B, Drociunas-Pacheco G, Moll WD, Schatzmayr G, Oswald IP. 2012. Chronic ingestion of deoxynivalenol and fumonisin, alone or in interaction, induces morphological and immunological changes in the intestine of piglets. Br. J. Nutr. 107: 1776-86.
  • Gauthier T, Wang X, Dos Santos JS, Fysikopoulos A, Tadrist S, Canlet C, Artigot MP, Loiseau N, Oswald IP,Puel O. 2012. Trypacidin, a spore borne toxin fromAspergillus fumigatus, induces cytotoxicity inlung cells. PLOSone 7: e29906.
  • Grenier B,Bracarense AP, Schwartz HE, Trumel C, Cossalter AM, Schatzmayr G, Kolf-Clauw M, Moll WD, Oswald IP. 2012. The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids. Biochem. Pharmacol. 83: 1465-73
  • Hopton R, Oswald IP, Hardie L, Turner P, Fisher J. 2012. Nuclear magnetic resonance analysis of glucose levels in weanling piglets plasma as a function of deoxynivalenol exposure. ISRN Anal Chem: Article ID 132543.
  • Jakšić D, Puel O, Canlet C, Kopjar N, Kosalec I, Klarić M. 2012. Cytotoxicity and genotoxicity of versicolorins and 5-methoxysterigmatocystin in A549 cells. Arch. Toxicol. 84: 641-50.
  • Mickiewicz M, Zabielski R, Grenier B, Le Normand L, Savary G, Holst JJ, Oswald IP, Metges CC, Guilloteau PP. 2012. Structural and functional development of small intestine in intrauterine growth retarded porcine offspring born to gilts fed diets with differing protein ratios throughout pregnancy. J. Physiol. Pharmacol. 63: 225-39.
  • Pacheco GD, Silva CA, Pinton P, Oswald IP, Bracarense AP. 2012. Phytic acid protects porcine intestinal epithelial cells from deoxynivalenol (DON) cytotoxicity. Exp. Toxicol. Pathol. 64: 345-7.
  • Pinton P, Guzylack-Piriou L, Kolf-Clauw M, Oswald IP. 2012. Effects of some fungal toxins, the trichothecenes, on the intestine. Curr. Immunol. Rev. 8: 193-208.
  • Pinton P, Tsybulskyy D, Lucioli J, Laffitte J, Callu P, Lyazhri F, Grosjean F, Bracarense AP, Kolf-Clauw M,Oswald IP. 2012. Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: differential effects on morphology, barrier function, tight junctions proteins and MAPKinases. Tox. Sci. 130: 180-90.
  • Seeboth J, Solinhac R, Oswald IP, Guzylack-Piriou L. 2012. The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in pigs. Vet. Res. 43: 35.
  • Siddique MH, Liboz T, Bacha N, Puel O, Mathieu F, Lebrihi A. 2012. Characterization of a cytochrome P450 monooxygenase gene involved in the biosynthesis of geosmin in Penicillium expansum. Afr. J. Microbiol. Res. 6: 4122-27.
  • Streit E, Schatzmayr G,Tassis P, Tzika E, Marin D, Taranu I, Tabuc C, Nicolau A, Aprodu I, Puel O, Oswald IP. 2012. Current Situation of Mycotoxin Contamination and Co-occurrence in Animal Feed - Focus on Europe. Toxins 4: 788-809.



  • Arnich N, Canivenc-Lavier C, Kolf-Clauw M, Coffigny H, Cravedi JP, Grob K, Macherey MC, Masset D, Maximilien R, Narbonne JF, Nesslany F, Stadler J, Tulliez J. 2011. Conclusions of the French Food Safety Agency on the toxicity of Bisphenol A. Int. J. Hyg. Environ. Health 214: 271-275.
  • Cabaret O, Puel O, Botterel F, Pean M, Bretagne S, Delaforge M. 2011. Contribution of uniformly 13C-enriched sterigmatocystin to the study of its pulmonary metabolism. Rapid. Comm. Mass Spectro. 25: 2704-10.
  • Fiebach AR, Guzylack-Piriou L, Python S, Summerfield A, Ruggli N. 2011. Classical Swine Fever virus npro limits type I interferon induction in plasmacytoid dendritic cells by interacting with interferon regulatory factor 7. J. Virol. 85: 8002-11.
  • Flori L, Gao Y, Oswald IP, Lefevre F, Bouffaud M, Mercat MJ, Bidanel JP, Rogel-Gaillard C. 2011. Deciphering the genetic control of innate and adaptive immune responses in pig: a combined genetic and genomic study. BMC Proceedings 5(Suppl 4): S32.
  • Flori L, Gao Y, Laloe D, Lemonier G, Teillaud A, Cossalter AM, Laffitte J, Pinton P, de Vaureix C, Bouffaud M, Mercat MJ, Lefevre F, Oswald IP, Bidanel JP, Rogel-Gaillard C. 2011. Immunity traits in pigs: substantial genetic variation and limited covariation. Plos One 6: e22717.
  • Grenier B, Loureiro-Bracarense AP, Lucioli J, Drociunas-Pacheco G, Cossalter AM, Moll WD, Schatzmayr G, Oswald IP. 2011. Individual and combined effects of subclinical doses of deoxynivalenol and fumonisins in piglets. Mol. Nutr. Food Res. 55: 761-71.
  • Grenier B, Oswald IP. 2011. Mycotoxin co-contamination of foods and feeds: meta-analysis of publications describing toxicological interactions. World Mycotoxin J. 4: 285-313.
  • Moulin HR, Liniger M, Python S, Guzylack-Piriou L, Ocaña-Macchi M, Ruggli N, Summerfield A. 2011. High interferon type I responses in the lung, plasma and spleen during highly pathogenic H5N1 infection of chicken. Vet. Res. 42: 6.
  • Trandaburu I, Oswald IP, Trandaburu T. 2011. The  immunohistochemical localization of the glycosphingolipid asialo-GM1 in the intestine of weaned piglets. Acta Histochemica 113: 103-8.



  • Cabaret O, Puel O, Botterel F, Pean M, Khoufache K, Costa JM, Delaforge M, Bretagne S. 2010. Metabolic detoxication pathways for sterigmatocystin in primary tracheal epithelial cells. Chem. Res. Toxicol. 23: 1673-81
  • Gao Y, Flori L. Lecardonnel J, Esquerre D, Hu Z, Teillaud A, Lemonier G, Lefevre F, Oswald IP,Rogel-Gaillard C. 2010. Transcritome analysis of porcine PBMC after stimulation by LPS or PMA/ionomycin using an expression array targeting the pig immune response. BMC genomics 11: 292.
  • Guzylack-Piriou L, Alves MP, Mccullough KC, Summerfield A. 2010. Porcine Flt3 ligand and its receptor: Generation of dendritic cells and identification of a new marker for porcine dendritic cells. Dev. Comp. Immunol. 34: 455-64.
  • Lallès JP, Lessard M, Oswald IP, David JC. 2010. Consumption of fumonisin B1 for 9 days induces stress proteins along the gastrointestinal tract of pigs. Toxicon 55: 244–9.
  • Pinton P, Braicu C, Nougayrede JP, Laffitte J, Taranu I, Oswald IP. 2010. Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a Mitogen Activated Protein kinase dependant mechanism. J. Nutr. 140: 1956–62.
  •  Puel O, Galtier P, Oswald IP. 2010. Biosynthesis and toxicological effects of patulin. Toxins 2: 613-631.


  • Artigot MP, Loiseau N, Laffitte J, Mas-Reguieg L, Tadrist S, Oswald IP, Puel O. 2009. Molecular cloning and functional characterization of two cytochromes P450 CYP619 involved in biosynthesis of patulin in Aspergillus clavatus. Microbiology 155: 1738-1747.
  • Dao HP, Atoui A, Mathieu F, Callaghan JO, Puel O, Liboz T, Dobson ADW, Lebrihi A. 2009. Cloning and characterization of novel methylsalicylic acid synthase gene involved in the biosynthesis of isoasperlactone and asperlactone in Aspergillus westerdijkiae. Fungal Genet. Biol. 46, 742-749.
  • Devriendt B*, Gallois M*, Verdonck F, Wache Y, Bimzok D, Oswald IP, Goddeeris BM, Cox E. 2009. The food contaminant fumonisin B1 reduces maturation of porcine CD11R1+ intestinal antigen presenting cells and antigen-specific immune responses, leading to a prolonged intestinal ETEC infection. Vet. Res. 40: 40.  * Equally contributed
  • Gallois M, Rothkötter HJ, Bailey M, Stokes CR and Oswald IP. 2009. Natural alternatives to in-feed antibiotics in pig production: Can immunomodulators play a role? Animal 3: 1644-1661.
  • Kolf-Clauw M, Castellote J, Joly B, Bourges-Abella N, Raymond I, Pinton P, Oswald IP. 2009. Development of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin DON: histopathological analysis. Toxicol. in vitro 23: 1580-84.
  • Le Gall M, Gallois M, Sève B, Holst JJ, Oswald IP, Lallès JP, Guilloteau P. 2009. Comparative effect of sodium butyrate administrated before or after weaning on growth and several indices of gastrointestinal biology of piglets. Br. J. Nutr. 102: 1285-96.
  • Lessard M, Boudry G, Sève B, Oswald IP, Lallès JP. 2009. Intestinal physiology and peptidase activity in male pigs are modulated by consumption of corn culture extracts containing fumonisins. J. Nutr. 139: 1303-1307.
  • Meissonnier GM, Raymond I, Laffite J,Cossalter AM, Pinton P, Benoit E, Bertin G, Galtier P, Oswald IP. 2009. Dietary glucomannan improves the vaccinal response in pigs exposed to AFB1 or T-2 toxin. World Mycotoxin J. 2: 161-172.
  • Pinton P, Nougayrede JP, del Rio JC, Moreno C, Marin D, Ferrier L, Bracarense AP, Kolf-Clauw M, Oswald IP. 2009. The food contaminant, deoxynivalenol, decreases intestinal barrier function and reduces claudin expression. Tox. Appl. Pharmacol. 237: 41-8.
  • Reyns T, De Boever S, Schauvliege S, Gasthuys F, Meissonnier GM, Oswald IP, Croubels S, De Backer P. 2009. Influence of administration route on the biotransformation of amoxicillin in the pig. J. Vet. Pharmacol. Ther. 32: 241-248.
  • Ruggli N, Summerfield A, Fiebach AR, Guzylack-Piriou L, Bauhofer O, Lamm CG, Waltersperger S, Matsuno K, Liu L, Gerber M, Choi KH, Hofmann MA, Sakoda Y, Tratschin JD. 2009. Classical swine fever virus can remain virulent after specific elimination of the interferon regulatory factor 3-degrading function of Npro. J. Virol. 83: 817-29.
  • Waché YJ, Valat C, Bougeard S, Burel C, Oswald IP, Fravalo P. 2009. Impact of Deoxynivalenol on the intestinal microflora of pigs. Int. J. Mol. Sci. 10: 1-17.


  • Bravin F, Duca RC, Loiseau N, Pean M, Puel O, Delaforge M. 2008. Production and use of mycotoxins uniformly enriched with stable isotopes for their dosage in biological samples, World Mycotoxin J. 1: 275-282.
  • Kosalec I, Puel O, Delaforge M, Kopjar N, Antolovi R, Jeli D, Marica B, Galtier P and Pepeljnjak S. 2008. Isolation and cytotoxicity of low-molecular-weight metabolites of Candida albicans. Front. Biosci. 13: 6893-904.
  • Meissonnier GM, Laffitte J, Raymond I, Benoit E, Cossalter AM, Pinton P, Bertin G, Oswald IP, Galtier P. 2008. Subclinical doses of T-2 toxin impair acquired immune response and liver cytochrome P450 in pigs. Toxicology 247: 46-54.
  • Meissonnier GM, Pinton P, Laffitte J, Cossalter AM, Gong YY, Wild CP, Berlin G, Galtier P, Oswald IP. 2008. Immunotoxicity of aflatoxin B1: impairment of the cell-mediated response to vaccine antigen and modulation of cytokine expression. Toxicol. Appl. Pharmacol. 231: 142-149.
  • Pinton P, Accensi F, Beauchamp E, Cossalter AM, Callu P, Grosjean F, Oswald IP. 2008. Ingestion of Deoxynivalenol (DON) contaminated feed alters the pig vaccinal immune responses. Toxicol. Lett. 177: 215-222.


  • Bouhet S and Oswald IP. 2007. The intestine as a possible target for fumonisin toxicity. Mol. Nutr. Food Res. 51: 925-931.
  • Cantiello M, Carletti M, Cannizzo FT, Nebbia C, Bellino C, Pie S, Oswald IP, Bollo E, Dacasto M. 2007. Effects of an illicit cocktail on serum immunoglobulins, lymphocyte proliferation and cytokine gene expression in the veal calf. Toxicology 242: 39-51.
  • Comera C, Andre K, Laffitte J, Collet X, Galtier P, Maridonneau-Parini I. 2007. Gliotoxin from Aspergillus fumigatus affects phagocytosis and the organization of the actin cytoskeleton by distinct signalling pathways in human neutrophils. Microbes Infect. 9: 47-54.
  • Gouze ME, Laffitte J, Pinton P, Dedieux G, Galinier A, Thouvenot JP, Loiseau N, Oswald IP, Galtier P. 2007. Effect of subacute oral doses of nivalenol on immune and metabolic defense systems in mice. Vet. Res. 38: 635-646.
  • Khoufache K*, Puel O*, Loiseau N, Delaforge M, Rivollet D, Coste A, Cordonnier C, Escudier E, Botterel F, Bretagne S. 2007. Verruculogen associated with Aspergillus fumigatus hyphae and conidia modifies the electrophysiological properties of human nasal epithelial cells. BMC Microbiol. 7: 5. * Equally contributed
  • Loiseau N, Debrauwer L, Sambou T, Bouhet S, Miller JD, Martin PG, Viadere JL, Pinton P, Puel O, Pineau T, Tulliez J, Galtier P, Oswald IP. 2007. Fumonisin B1 exposure and its selective effect on porcine jejunal segment: Sphingolipids, glycolipids and trans-epithelial passage disturbance. Biochem. Pharmacol. 74: 144-152.
  • Marin DE, Gouze ME, Taranu I, Oswald IP. 2007. Fumonisin B1 alters cell cycle progression and interleukin-2 synthesis in swine peripheral blood mononuclear cells. Mol. Nutr. Food Res. 51: 1406-1412.
  • Meissonnier GM, Laffitte J, Loiseau N, Benoit E, Raymond I, Pinton P, Cossalter AM, Bertin G, Oswald IP, Galtier P. 2007. Selective impairment of drug-metabolizing enzymes in pig liver during subchronic dietary exposure to aflatoxin B1. Food Chem. Toxicol. 45: 2145-2154.
  • Picherot M, Oswald IP, Cote M, Noeckler K, Le Guerhier F, Boireau P, Vallée I. 2007. Swine infection with Trichinella spiralis: Comparative analysis of the mucosal intestinal and systemic immune responses. Vet. Parasitol. 143: 122-130.
  • Pie S, Awati A, Vida S, Falluel I, Williams BA, Oswald IP. 2007. Effects of added fermentable carbohydrates in the diet on intestinal pro-inflammatory cytokine expression in weaning piglets. J. Anim. Sci. 85: 673-683.
  • Puel O, Tadrist S, Delaforge M, Oswald IP, Lebrihi A. 2007. The inability of Byssochlamys fulva to produce patulin is related to absence of 6-methylsalicylic acid synthase and isoepoxydon dehydrogenase genes. Int. J. Food Microbiol. 115: 131-139.
  • Techau ME, Johansen MV, Aasted B, Lind P, Ornbjerg N, Oswald IP. 2007. Cytokine mRNA profiles in pigs exposed prenatally and postnatally to Schistosoma japonicum. Vet. Res. 38: 25-36.


  • Accensi F, Pinton P, Callu P, Abella-Bourges N, Guelfi JF, Grosjean F, Oswald IP. 2006. Ingestion of low doses of deoxynivalenol does not affect hematological, biochemical, or immune responses of piglets. J. Anim. Sci. 84: 1935-1942.
  • Bouhet S, Le Dorze E, Peres S, Fairbrother JM, Oswald IP. 2006. Mycotoxin fumonisin B-1 selectively down-regulates the basal IL-8 expression in pig intestine: in vivo and in vitro studies. Food Chem. Toxicol. 44: 1768-1773.
  • Gouze ME, Laffitte J, Rouimi P, Loiseau N, Oswald IP, Galtier P. 2006. Effect of various doses of deoxynivalenol on liver xenobiotic metabolizing enzymes in mice. Food Chem. Toxicol. 44: 476-483.
  • Marin DE, Taranu I, Bouhet S, Oswald IP. 2006. Effects of a food contaminant, the mycotoxin fumonisin B1, on cytokine production: implication for the immune response to vaccination. Curr. Trends Immunol. 7: 137-43.
  • Marin DE, Taranu I, Pascale F, Lionide A, Burlacu R, Bailly JD, Oswald IP. 2006. Sex-related differences in the immune response of weanling piglets exposed to low doses of fumonisin extract. Br. J. Nutr. 95: 1185-11923.
  • Oswald IP. 2006. Role of intestinal epithelial cells in the innate immune defence of the pig intestine. Vet. Res. 37: 359-368.


  • Bouhet S, Oswald IP. 2005. The effects of mycotoxins, fungal food contaminants, on the intestinal epithelial cell-derived innate immune response. Vet. Immunol. Immunopathol. 108: 199-209.
  • Dacasto M, Eeckhoutte C, Capolonga F, Dupuy J, Carletti M, Calléja C, Nebbia C, Alvinerie M, Galtier P. 2005. Effect of breed and gender on bovine liver cytochrome P450 3A (CYP3A) expression and inter-species comparison with other domestic ruminants. Vet. Res. 36: 179-90.
  • Girard F, Oswald IP, Taranu I, Helie P, Appleyard GD, Harel J, Fairbrother JM. 2005. Host immune status influences the development of attaching and effacing lesions in weaned pigs. Infect. Immun. 73: 5514-5523.
  • Gouze ME, Laffitte J, Dedieu G, Galinier A, Thouvenot JP, Oswald IP, Galtier P. 2005. Individual and combined effects of low oral doses of deoxynivalenol and nivalenol in mice. Cell Mol. Biol. 51: OL809-OL817.
  • Halloy DJ, Gustin PG, Bouhet S, Oswald IP. 2005. Oral exposure to culture material extract containing fumonisins predisposes swine to the development of pneumonitis caused by Pasteurella multocida. Toxicology 213: 34-44.
  • Oswald IP, Marin DE, Bouhet S, Pinton P, Taranu I, Accensi F. 2005. Immunotoxicological risk of mycotoxins for domestic animals. Food Add. Contam. 22: 354-360.
  • Puel O, Tadrist S, Galtier P, Oswald IP, Delaforge M. 2005. Byssochlamys nivea as a source of mycophenolic acid. Appl. Environ. Microbiol. 71: 550-553.
  • Roselli M, Finamore A, Britti MS, Bosi P, Oswald I, Mengheri E. 2005. Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results. Anim. Res. 54: 203-218.
  • Taranu I, Marin DE, Bouhet S, Pascale F, Bailly JD, Miller JD, Pinton P, Oswald IP. 2005. Mycotoxin fumonisin B-1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs. Toxicol. Sci. 84: 301-307.