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Laboratory of Plant-Microbe Interactions - LIPM

Laboratory of Plant-Microbe Interactions

Publications - Responses to stress and environmental signals in rhizobia


Berrabah, F., Ratet, P., Gourion B. (2019) Legume nodule: massive infection in the absence of defense induction Mol Plant Microbe Interact 32(1):35-44.


Dupuy, P., Sauviac, L., Bruand, C. (2018) Stress-inducible NHEJ in bacteria: function in DNA repair and acquisition of heterologous DNA Nucleic Acid Research in press

Berrabah, F., Balliau, T., Aït-Salem, E-H., George, J., Zivy, M., Ratet, P., Gourion B. (2018) Control of the ethylene signaling pathway prevents plant defenses during intracellular accomodation of the rhizobia New Phytol 219(1):310-323.

Sang Y, Wang Y, Ni H, Cazalé AC, She YM, Peeters N, Macho AP. (2018) The Ralstonia solanacearum type III effector RipAY targets plant redox regulators to suppress immune responses. Mol Plant Pathol 19(1):129-142.

Gourion, B., Alunni, B. (2018) Strain-specific symbiotic genes: a new level of control in the intracellular accommodation of rhizobia within legume nodule cells. Mol Plant Microbe Interact 31(3):287-288.


Dupuy, P., Gourion, B., Sauviac, L., Bruand, C. (2017) DNA double-strand break repair is involved in desiccation resistance of Sinorhizobium meliloti, but is not essential for its symbiotic interaction with Medicago truncatula. Microbiology 163: 333-342 Full text

Lonjon F, Lohou D, Cazalé AC, Büttner D, Ribeiro BG, Péanne C, Genin S, Vailleau F. (2017) HpaB-Dependent Secretion of Type III Effectors in the Plant Pathogens Ralstonia solanacearum and Xanthomonas campestris pv. vesicatoria. Sci Rep7(1):4879

Brusamarello-Santos LC, Gilard F, Brulé L, Quilleré I, Gourion B, Ratet P, Maltempi de Souza E, Lea PJ, Hirel B. (2017) Metabolic profiling of two maize (Zea mays L.) inbred lines inoculated with the nitrogen fixing plant-interacting bacteria Herbaspirillum seropedicae and Azospirillum brasilense. PLoS One 12(3):e0174576


Alunni, B., Gourion, B. (2016) Terminal bacteroid differentiation in the legume-rhizobium symbiosis: nodule-specific cysteine-rich peptides and beyond. New Phytol 211(2):411-7 Full text

Lonjon F, Turner M, Henry C, Rengel D, Lohou D, van de Kerkhove Q, Cazalé AC, Peeters N, Genin S, Vailleau F. (2016) Comparative Secretome Analysis of Ralstonia solanacearum Type 3 Secretion-Associated Mutants Reveals a Fine Control of Effector Delivery, Essential for Bacterial Pathogenicity. Mol Cell Proteomics 15(2):598-613


Blanquet, P., Silva, L., Catrice, O., Bruand, C., Carvalho, H., and Meilhoc, E. (2015) Sinorhizobium meliloti controls NO-mediated post-translational modification of a Medicago truncatula nodule protein. Mol Plant Microbe Interact 28(12):1353-63 Abstract Full text    

Sauviac, L., Bastiat, B., and Bruand, C. (2015) The general stress response in alpha-rhizobia (review) In Biological Nitrogen Fixation, F.J. de Bruijn (ed), Wiley-Blackwell (Hoboken, NJ, USA), p. 405-414.

Meilhoc, E., Boscari, A., Brouquisse, R., and Bruand, C. (2015) Multifaceted roles of nitric oxide in legume-rhizobium symbioses (review) In Biological Nitrogen Fixation, F.J. de Bruijn (ed), Wiley-Blackwell (Hoboken, NJ, USA), p. 637-648.

Vriezen, J.A.C., and de Bruijn, F.J. (2015) Appearance of membrane compromised, viable but not culturable and culturable rhizobial cells as a consequence of desiccation. In Biological Nitrogen Fixation, de Bruijn F.J. (ed), Wiley-Blackwell (Hoboken, NJ, USA), p. 977-989.

de Bruijn, F.J. (2015) The quest for biological nitrogen fixation in cereals : a perspective and prospective. In Biological Nitrogen Fixation, F.J. de Bruijn (ed), Wiley-Blackwell (Hoboken, NJ, USA), p. 1089-1101.

de Bruijn, F.J. (2015) Biological Nitrogen Fixation, Vol 1 and 2, FJ de Bruijn (ed), Wiley-Blackwell (Hoboken, NJ, USA)

de Bruijn, F.J. (2015) Biological nitrogen fixation. In Principles of Plant-Microbe interactions, Microbes for sustainable agriculture, B. Lugtenberg (ed), Springer International Publishing, Switzerland.


Sauviac, L., and Bruand, C. (2014) A putative bifunctional histidine kinase/phosphatase of the HWE family exerts positive and negative control on the Sinorhizobium meliloti general stress response. J Bacteriol 196:2526-35. Full text

Roux, B., Rodde, N., Jardinaud, M.F., Timmers, T., Sauviac, L., Cottret, L., Carrère, S., Sallet, E., Courcelle, E., Moreau, S., Debellé, F., Capela, D., de Carvalho-Niebel, F., Gouzy, J., Bruand, C., and Gamas, P. (2014) An integrated analysis of plant and bacterial gene expression in symbiotic root nodules using laser-capture microdissection coupled to RNA sequencing. Plant J 77:817-837. Full text


Savka, M.A., Dessaux, Y., McSpadden Gardener, B.B., Mondy, S., Kohler, P.R.A., de Bruijn, F.J., and Rossbach, S. (2013) The “biased rhizosphere” concept and advances in the omics era to study bacterial competitiveness and persistence in the phytosphere. In Molecular Microbial Ecology of the Rhizosphere (de Bruijn, F.J., ed), John Wiley & Sons, Inc., Hoboken, NJ, USA., 1147-1161

Boscari, A., Meilhoc, E., Castella, C., Bruand, C., Puppo, A., and Brouquisse, R. (2013) Which role for nitric oxide in symbiotic N2-fixing nodules: toxic by-product or useful signaling/metabolic intermediate? Front Plant Sci 4:384. Review Full text

Vriezen, J.A., de Bruijn, F.J., and Nüsslein, K. (2013) Identification and characterization of a NaCl-responsive genetic locus involved in survival during desiccation in Sinorhizobium meliloti. Appl Environ Microbiol 79:5693-700. Full text

Meilhoc, E., Blanquet, P., Cam, Y., and Bruand, C. (2013) Control of NO level in rhizobium-legume root nodules: Not only a plant globin story. Plant Signal Behav 8:e25923. Full text

Sallet, E., Roux, B., Sauviac, L., Jardinaud, M.-F., Carrère, S., Faraut, T., de Carvalho-Niebel, F., Gouzy, J., Gamas, P., Capela, D., Bruand, C., and Schiex, T. (2013) Next-generation annotation of prokaryotic genomes with EuGene-P: application to Sinorhizobium meliloti 2011. DNA Res 20:339-354. Full text

de Bruijn, F.J. (2013) Molecular Microbial Ecology of the Rhizosphere, Volume I & II. (de Bruijn, F.J., ed), John Wiley & Sons, Inc., Hoboken, NJ, USA.


Bastiat, B., Sauviac, L., Picheraux, C., Rossignol, M., and Bruand, C. (2012) Sinorhizobium meliloti sigma factors RpoE1 and RpoE4 are activated in stationary phase in response to sulfite. PLoS One 7:e50768. Full text 

Cam, Y., Pierre, O., Boncompagni, E., Hérouart, D., Meilhoc, E., and Bruand, C. (2012) Nitric oxide (NO): a key player in the senescence of Medicago truncatula root nodules. New Phytol 196: 548-560. Full text

Vriezen, J.A., de Bruijn, F.J., and Nüsslein, K.R. (2012) Desiccation induces viable but non-culturable cells in Sinorhizobium meliloti 1021. AMB Express 2:6.  Full text


Meilhoc, E., Boscari, A., Bruand, C., Puppo, A., and Brouquisse, R. (2011) Nitric oxide in legume-rhizobium symbiosis. Plant Sci 181:573-581. Review  Full text

de Bruijn, F.J. (2011) Handbook of Molecular Microbial Ecology I: Metagenomics and complementary approaches & II: Metagenomics in different habitats (de Bruijn, F.J., ed), John Wiley & Sons, Inc., Hoboken, NJ, USA.

del Giudice, J., Cam, Y., Damiani, I., Fung-Chat, F., Meilhoc, E., Bruand, C., Brouquisse, R., Puppo, A., and Boscari, A. (2011) Nitric oxide is required for an optimal establishment of the Medicago truncatula-Sinorhizobium meliloti symbiosis. New Phytol 191:405-417.  Full text

Horchani, F., Prevot, M., Boscari, A., Evangelisti, E., Meilhoc, E., Bruand, C., Raymond, P., Boncompagni, E., Aschi-Smiti, S., Puppo, A., and Brouquisse, R. (2011) Both plant and bacterial nitrate reductases contribute to nitric oxide production in Medicago truncatula nitrogen-fixing nodules. Plant Physiol 155: 1023-1036. Full text 


Bastiat, B., Sauviac, L., and Bruand, C. (2010) Dual control of Sinorhizobium meliloti RpoE2 sigma factor activity by two PhyR-type two-component response regulators. J Bacteriol 192: 2255-2265. Full text 

Meilhoc, E., Cam, Y., Skapski, A., and Bruand, C. (2010) The response to nitric oxide of the nitrogen-fixing symbiont Sinorhizobium meliloti. Mol Plant Microbe Interact 23: 748-759. Full text 

Before 2010

Rossbach, S., Mai, D.J., Carter, E.L., Sauviac, L., Capela, D., Bruand, C., and de Bruijn, F.J. (2008) Response of Sinorhizobium meliloti to elevated concentrations of cadmium and zinc. Appl Environ Microbiol 74: 4218-4221. Full text

Vriezen, J.A., de Bruijn, F.J. and Nussslein K. (2007) Responses of rhizobia to dessication in relation to osmotic stress, oxygen and temperature.  Appl Environ Microbiol 72, 3451-3459. Full text 

Rossbach, S., de Bruijn, F.J., (2007) Transposon mutagenesis.  In: Methods for General and Molecular Microbiology., Ed. C.A Reddy, American Society for Microbiology, Washington, DC, PP. 684-708  

Sauviac, L., Philippe, H., Phok, K., and Bruand, C. (2007) An extracytoplasmic function sigma factor acts as a general stress response regulator in Sinorhizobium meliloti. J Bacteriol 189: 4204-4216. Full text 

Vriezen, J.A.C., Wopereis, J.,  de Bruijn, F.J., Nusslein, K. (2006) Dessication responses of Sinorhizobium meliloti USDA 1021 in relation to growth phase, temperature, chloride and sulfate availability. (2006) Lett Appl Microbiol 42, 172-178.  Full text

de Bruijn, F.J., Rossbach, S., Bruand, C., and Parrish, J.R. (2006) A highly conserved Sinorhizobium meliloti operon is induced microaerobically via the FixLJ system and by nitric oxide (NO) via NnrR. Environ Microbiol  8: 1371-1381.  Full text

Bobik, C., Meilhoc, E., and Batut, J. (2006) FixJ: a major regulator of the oxygen limitation response and late symbiotic functions of Sinorhizobium meliloti. J Bacteriol 188: 4890-4902. Full text 

Capela, D., Filipe, C., Bobik, C., Batut, J., and Bruand, C. (2006) Sinorhizobium meliloti differentiation during symbiosis with alfalfa: a transcriptomic dissection. Mol Plant Microbe Interact19: 363-372.  Full text