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  • Bettini S, Boutet-Robinet E, Cartier C, Coméra C, Gaultier E, Dupuy J, Naud N, Taché S, Grysan P, Reguer S, Thieriet N, Réfrégiers M, Thiaudière D, Cravedi JP, Carrière M, Audinot JN, Pierre FH, Guzylack-Piriou L, Houdeau E. Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon. Sci Rep. 2017 ; 7:40373.
  • Malaisé Y, Menard S, Cartier C, Gaultier E, Lasserre F, Lencina C, Harkat C, Geoffre N, Lakhal L, Castan I, Olier M, Houdeau E, Guzylack-Piriou L. Gut dysbiosis and impairment of immune system homeostasis in perinatally-exposed mice to Bisphenol A precede obese phenotype development. Sci Rep. 2017 ; 7:14472
  • Riba A, Olier M, Lacroix-Lamandé S, Lencina C, Bacquié V, Harkat C, Gillet M, Baron M, Sommer C, Mallet V, Salvador-Cartier C, Laurent F, Théodorou V, Ménard S. Paneth Cell Defects Induce Microbiota Dysbiosis in Mice and Promote Visceral Hypersensitivity. Gastroenterology. 2017 ; doi: 10.1053/j.gastro.2017.08.044. [In press]
  • Malaisé Y, Ménard S, Cartier C, Lencina C, Sommer C, Gaultier E, Houdeau E, Guzylack-Piriou L. Consequences of bisphenol a perinatal exposure on immune responses and gut barrier function in mice. Arch Toxicol. 2017 ; doi: 10.1007/s00204-017-2038-2. [In press]
  • Dorier M, Béal D, Marie-Desvergne C, Dubosson M, Barreau F, Houdeau E, Herlin-Boime N, Carrière M. Continuous in vitro exposure of intestinal epithelial cells to E171 food additive causes oxidative stress, inducing oxidation of DNA bases but no endoplasmic reticulum stress. Nanotoxicology. 2017 ;11:751-761.


  • Mercier-Bonin M, Despax B, Raynaud P, Houdeau E, Thomas M. Mucus and microbiota as emerging players in gut nanotoxicology: The example of dietary silver and titanium dioxide nanoparticles. Crit Rev Food Sci Nutr. 2016 ; 14:1-10. Review.
  • Hessel EV, Ezendam J, van Broekhuizen FA, Hakkert B, DeWitt J, Granum B, Guzylack L, Lawrence BP, Penninks A, Rooney AA, Piersma AH, van Loveren H. Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI. Reprod Toxicol. 2016 ; 65:448-456.
  • Houdeau E. Sex differences in gastrointestinal physiology and diseases : from endogenous sex hormones to environmental endocrine disruptor agents. Neigh G, Mitzelfelt M (Eds). In: Sex Differences in Physiology. Elsevier. 2016 ; pp125-143. Book chapter.
  • Guzylack-Piriou L, Malaisé Y, Cartier C, Lencina C, Sommer C, Gaultier E, Houdeau E, Ménard S. Dysregulation of intestinal and systemic immune responses in adults after perinatal exposure to bisphenol A (BPA): Possible involvement of adverse food reactions. Revue Française d’Allergologie. 2016 ; 56:135-136


  • Da Silva S, Robbe-Masselot C, Raymond A, Mercade-Loubière M, Salvador-Cartier C, Ringot B, Léonard R, Fourquaux I, Ait-Belgnaoui A, Loubière P, Theodorou V, Mercier-Bonin M. Spatial Localization and Binding of the Probiotic Lactobacillus farciminis to the Rat Intestinal Mucosa: Influence of Chronic Stress. PLoS One. 2015 ;10:e0136048


  • Menard S, Guzylack-Piriou L, Leveque M, Braniste V, Lencina C, Naturel M, Moussa L, Sekkal S, Harkat C, Gaultier E, Theodorou V, Houdeau E. Food intolerance at adulthood after perinatal exposure to the endocrine disruptor bisphenol A. FASEB J. 2014 ; 28:4893-900.
  • Bettini S, Houdeau E. Oral exposure to titanium dioxide (TiO₂) nanoparticles: from translocation through oral and intestinal epithelia to fate and effects in the organism. Biol Aujourdhui. 2014 ; 208:167-75. Review.
  • Ménard S, Guzylack-Piriou L, Lencina C, Leveque M, Naturel M, Sekkal S, Harkat C, Gaultier E, Olier M, Garcia-Villar R, Theodorou V, Houdeau E. Perinatal exposure to a low dose of bisphenol A impaired systemic cellular immune response and predisposes young rats to intestinal parasitic infection. PLoS One. 2014 ; 9:e112752.
  • Da Silva S, Robbe-Masselot C, Ait-Belgnaoui A, Mancuso A, Mercade-Loubière M, Salvador-Cartier C, Gillet M, Ferrier L, Loubière P, Dague E, Theodorou V, Mercier-Bonin M. Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment. Am J Physiol Gastrointest Liver Physiol. 2014 ; 307:G420-9.
  • Nébot-Vivinus M, Harkat C, Bzioueche H, Cartier C, Plichon-Dainese R, Moussa L, Eutamene H, Pishvaie D, Holowacz S, Seyrig C, Piche T, Theodorou V. Multispecies probiotic protects gut barrier function in experimental models. World J Gastroenterol. 2014 ; 20:6832-43.
  • Payros D, Secher T, Boury M, Brehin C, Ménard S, Salvador-Cartier C, Cuevas-Ramos G, Watrin C, Marcq I, Nougayrède JP, Dubois D, Bedu A, Garnier F, Clermont O, Denamur E, Plaisancié P, Theodorou V, Fioramonti J, Olier M, Oswald E. Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis. Gut Microbes. 2014 ; 5:313-25.
  • Ait-Belgnaoui A, Colom A, Braniste V, Ramalho L, Marrot A, Cartier C,Houdeau E, Theodorou V, Tompkins T. Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice. Neurogastroenterol Motil. 2014 ; 26:510-20.
  • Moussaoui N, Braniste V, Ait-Belgnaoui A, Gabanou M, Sekkal S, Olier M, Theodorou V, Martin PG, Houdeau E. Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats. PLoS One. 2014 ; 9:e88382.



  • Moussa L, Bézirard V, Salvador-Cartier C, Bacquié V, Houdeau E, Theodorou V. A new soy germ fermented ingredient displays estrogenic and protease inhibitor activities able to prevent irritable bowel syndrome-like symptoms in stressed female rats. Clin Nutr 2013 ; 32:51-8.
  • Gaigé S, Bonnet M, Tardivel C, Pinton P, Trouslard J, Jean A, Guzylack-Piriou L, Troadec J-D, Dallaporta M. C-Fos immunoreactivity in the pig brain following deoxynivalenol intoxication: focus on NUCB2/nesfatin-1 expressing neurons. Toxicology 2013 ; 34:135-49.
  • Cano PM, Seeboth J, Meurens F, Cognie J, Abrami R, Oswald IP, Guzylack-Piriou L. Deoxynivalenol as a new factor in the persistence of intestinal inflammatory diseases: an emerging hypothesis through possible modulation of Th17-mediated response. PLoS One 2013 ; 8:e53647.



  • Moussa L, Bézirard V, Salvador-Cartier C, Bacquié V, Lencina C, Lévêque M, Braniste V, Ménard S, Theodorou V, Houdeau E. A low dose of fermented soy germ alleviates gut barrier injury, hyperalgesia and faecal protease activity in a rat model of inflammatory bowel disease. PLoS One 2012 ; 7:e49547.
  • Braniste V, Houdeau E. Gut: a new target for endocrine disruptors. Cahiers de Nutrition et de Diététique 2012 ; 47:193-200.
  • Houdeau E. Nanoparticules et barrière intestinale: comprendre les mécanismes de franchissement. Innovations Agronomiques 2012 ; 24:105-112.
  • Seeboth J, Solinhac R, Oswald IP, Guzylack-Piriou L. The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig. Vet Res 2012 ; 43:35.
  • Pinton P, Guzylack-Piriou L, Kolf-Clauw M, Oswald IP. The Effect on the Intestine of Some Fungal Toxins: The Trichothecenes. Current Immunology Reviews 2012 ; 8:193-208.
  • Ait-Belgnaoui A, Durand H, Cartier C, Chaumaz G, Eutamene H, Ferrier L, Houdeau E, Fioramonti J, Bueno L, Theodorou V. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinology 2012 ; 37:1885-95.



  • Braniste V, Audebert M, Zalko D, Houdeau E. Bisphenol A in the Gut: Another Break in the Wall? In Multi-System Endocrine Disruption - Series: Research and Perspectives in Endocrine Interactions. Bourguignon J-P, Jégou B, Kerdelhué B, Toppari J, Christen Y (Eds). Springer-Verlag Berlin Heidelberg 2011, pp127.
  • Fiebach AR, Guzylack-Piriou L, Python S, Summerfield A, Ruggli N. Classical swine fever virus N(pro) limits type I interferon induction in plasmacytoid dendritic cells by interacting with interferon regulatory factor 7. J Virol 2011 ; 85:8002-11.
  • Houdeau E. Endocrine disruptors and oral contamination: the forgotten gut. Médecine & Longévité 2011 ; 3:85-93.



  • Guzylack-Piriou L, Alves MP, McCullough KC, Summerfield A. Porcine Flt3 ligand and its receptor: generation of dendritic cells and identification of a new marker for porcine dendritic cells. Dev Comp Immunol 2010 ; 34:455-64.
  • Braniste V, Jouault A, Gaultier E, Polizzi A, Buisson-Brenac C, Leveque M, Martin PG, Theodorou V, Fioramonti J, Houdeau E. Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats. Proc Natl Acad Sci USA 2010 ; 107:448-53.
  • Agostini S, Eutamene H, Cartier C, Broccardo M, Improta G, Houdeau E, Petrella C, Ferrier L, Theodorou V, Bueno L. Evidence of Central and Peripheral Sensitization in a Rat Model of Narcotic Bowel Like-Syndrome. Gastroenterology 2010 ; 139:553-63.



  • Braniste V, Leveque M, Buisson-Brenac C, Bueno L, Fioramonti J, Houdeau E. Oestradiol decreases colonic permeability through oestrogen receptor beta-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells. J Physiol 2009 ; 587(Pt 13):3317-28.
  • Ait-Belgnaoui A, Eutamene H, Houdeau E, Bueno L, Fioramonti J, Theodorou V. Lactobacillus farciminis treatment attenuates stress-induced overexpression of Fos protein in spinal and supraspinal sites after colorectal distension in rats. Neurogastroenterol Motil 2009 ; 21:567-73.
  • Alves MP, Guzylack-Piriou L, Juillard V, Audonnet J-C, Doel T, Dawson H, Golde WT, Gerber H, Peduto N, McCullough KC, Summerfield A. Innate immune defences induced by CpG do not promote vaccine-induced protection against foot and mouth disease virus in pigs. Clin Vaccine Immunol 2009 ; 16:1151-8.
  • Summerfield A, Guzylack-Piriou L, Harwood L, McCullough KC. Innate immune responses against foot-and-mouth disease virus: current understanding and future directions. Vet Immunol Immunopathol 2009 ; 128:205-210.
  • Ruggli N, Summerfield A, Fiebach AR, Guzylack-Piriou L, Bauhofer O, Lamm CG, Waltersperger S, Matsuno K, Liu L, Gerber M, Choi KH, Hofmann MA, Sakoda Y, Tratschin J-D. Classical swine fever virus can remain virulent after specific elimination of the interferon regulatory factor 3-degrading function of Npro. J Virol 2009 ; 83:817-829.
  • Wache YJ, Hbabi-Haddioui L, Guzylack-Piriou L, Belkhelfa H, Roques C, Oswald IP. The mycotoxin Deoxynivalenol inhibits the cell surface expression of activation markers in human macrophages. Toxicology 2009 ; 262:239-244.


2005-2008 (selection)

  • Barreau F, Salvador-Cartier C, Houdeau E, Bueno L, Fioramonti J. Long-term alterations of colonic nerve-mast cell interactions induced by neonatal maternal deprivation in rats. Gut 2008 ; 57:582-90.
  • Piriou-Guzylack L, Salmon H. Membrane markers of the immune cells in swine: an update. Vet Res 2008 ; 39:54.
  • Pascale F, Contreras V, Bonneau M, Courbet A, Chilmonczyk S, Bevilacqua C, Eparaud M, Niborski V, Riffault S, Balazuc A-M, Foulon E, Guzylack-Piriou L, Riteau B, Hope J, Bertho N, Charley B, Schartz-Cornil I. Plasmacytoid dendritic cells migrate in afferent skin lymph. J Immunol 2008 ; 180:5963-5972.
  • Houdeau E, Moriez R, Leveque M, Salvador-Cartier C, Waget A, Leng L, Bueno L, Bucala R, Fioramonti J. Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat. Gastroenterology 2007 ; 132:982-93.
  • Alves MP, Neuhaus V, Guzylack-Piriou L, Ruggli N, McCullough KC, Summerfield A. Toll-like receptor 7 and MyD88 knockdown by lentivirus-mediated RNA interference to porcine dendritic cell subsets. Gene Ther 2007 ; 14:836-844.
  • Piersma SJ, Leenaars MP, Guzylack-Piriou L, Summerfield A, Hendriksen CF, McCullough KC. An in vitro immune response model to determine tetanus toxoid antigen (vaccine) specific immunogenicity: Selection of sensitive assay criteria. Vaccine 2006 ; 24:3076-3083.
  • Guzylack-Piriou L, Bergamin F, Gerber M, McCullough KC, Summerfield A. Plasmacytoid dendritic cell activation by foot-and-mouth disease virus requires immune complexes. Eur J Immunol 2006 ; 36:1674-1683.
  • Guzylack-Piriou L, Piersma S, McCullough K, Summerfield A. Role of natural interferon-producing cells and T lymphocytes in porcine monocyte-derived dendritic cell maturation. Immunology 2006 ; 118:78-87.
  • Houdeau E, Larauche M, Monnerie R, Bueno L, Fioramonti J. Uterine motor alterations and estrous cycle disturbances associated with colonic inflammation in the rat. Am J Physiol Regul Integr Comp Physiol 2005 ; 288:R630-7.
  • Vincent IE, Carrasco CP, Guzylack-Piriou L, Herrmann B, McNeilly F, Allan GM, Summerfield A, McCullough KC. Subset-dependent modulation of dendritic cell activity by circovirus type 2. Immunology 2005 ; 115:388-398.
  • Balmelli C, Vincent IE, Rau H, Guzylack-Piriou L, McCullough K, Summerfield A. Fc gamma RII-dependent sensitisation of natural interferon-producing cells for viral infection and interferon-alpha responses. Eur J Immunol 2005 ; 35:2406-2415.
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