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Laboratory of Plant-Microbe Interactions - LIPM

Laboratory of Plant-Microbe Interactions

Plant resistance pathway dynamics and adaptation to global warming

The research goal in our team is to understand how plant activate and regulate their immune responses towards bacterial pathogens, and how does the environmental conditions modulate plant immunity.

Using a pathosystem involving the root bacterial pathogen Ralstonia solanacearum in interaction with the model species Arabidopsis thaliana, we recently described an exquisite immune receptor decoy mechanism that converts a potent bacterial virulence activity into defense gene activation (collaboration with J. E. Parker’s group). We are utilizing genetics, biochemical, and microscopy confocal approaches to investigate:

(i) the mode of action of bacterial effectors that target host epigenetic machinery to dampen immunity,

(ii) the mechanisms by which DNA-bound immune receptors connect functionally to the chromatin environment and transcriptional machinery for cellular defence reprogramming,

(iii) new resistance mechanisms remaining efficient under permanent temperature rises.

Plant resistance pathway dynamics and adaptation to global warming